DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zif and ZNF721

DIOPT Version :9

Sequence 1:	NP_001189188.1	Gene:	Zif / 40795	FlyBaseID:	FBgn0037446	Length:	388	Species:	Drosophila melanogaster
Sequence 2:	NP_597731.2	Gene:	ZNF721 / 170960	HGNCID:	29425	Length:	923	Species:	Homo sapiens

Alignment Length:	428	Identity:	103/428 - (24%)
Similarity:	148/428 - (34%)	Gaps:	141/428 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 NLNDREHIPDG----ICKSCKVELNMAYQFREKALRKQMEIEE---YCRELGLLDESDVMMIK-- 103
            :||..|.|..|    .||.|...:..:..|   |..|::...|   .|.|.|....|...:.|
Human   459 HLNKHEKIHTGKKPYKCKQCGKVITSSSSF---AKHKRIHTGEKPFECLECGKAFTSSTTLTKHR 520

  Fly   104 ---------------------------------------EEDGSQQQCDEEMYILEETTTGEEEH 129
                                                   ||.|...:....:|:.....|||:.:
Human   521 RIHTGEKPYTCEVCGKAFRQSAILYVHRRIHTGEKPYTCEECGKTFRQSANLYVHRRIHTGEKPY 585

  Fly   130 Q-EEKGH--------EEYLEVDTSDQ----QECIGDTIEYLEDNYTIEMNSDQTEIVLESEKQY- 180
            : ||.|.        .::.::.|.::    :||..|.:.|.:.|        |.:.:...||.|
Human   586 KCEECGKAFGRYTDLNQHKKIHTGEKLYKCEECGKDFVWYTDLN--------QQKKIYTGEKPYK 642

  Fly   181 -EE------------------TPSQQLALQEAAKA-----SLKARRGRVRRGLNSLTTSDGTEKG 221
             ||                  |..|....:|..||     :|...: ::..|          ||
Human   643 CEECGKAFAPSTDLNQHTKILTGEQSYKCEECGKAFGWSIALNQHK-KIHTG----------EK- 695

  Fly   222 GYICDVCGNFY---------------------EKRGR-------MMEHRRRHDGICQYACELCDA 258
            .|.|:.||..:                     |.|||       :.|:::.|.|...|.|:.|..
Human   696 PYKCEECGKAFSRSRNLTTHRRVHTREKPYKCEDRGRSFGWSTNLNEYKKIHTGDKLYKCKECGK 760

  Fly   259 KFQVREQLRKHMYSHTGSKPYKCSFCSRQFFYESVLKSHENVHRGIKPYVCKVCDKAFAYAHSLT 323
            .|:....|.:|...|||.|||||..|.:.....|....|:.:|.|.||:.|..|.|||..:.:||
Human   761 VFKQSSHLNRHEKIHTGKKPYKCKECGKVITSSSSFAKHKRIHTGEKPFKCLECGKAFTSSTTLT 825

  Fly   324 KHELIHSDIKLYRCDYCNKDFR----LLHHMRQHEETK 357
            ||..||:..|.|.|:.|.|.||    |..|.|.|...|
Human   826 KHRRIHTGEKPYTCEECGKAFRQSAILYVHRRIHTGEK 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zif	NP_001189188.1	zf-AD	9..87	CDD:285071	12/45 (27%)
		C2H2 Zn finger	225..245	CDD:275368	8/47 (17%)
		COG5048	<250..369	CDD:227381	44/112 (39%)
		C2H2 Zn finger	253..273	CDD:275368	5/19 (26%)
		zf-H2C2_2	266..288	CDD:290200	11/21 (52%)
		C2H2 Zn finger	281..301	CDD:275368	4/19 (21%)
		zf-H2C2_2	294..318	CDD:290200	10/23 (43%)
		C2H2 Zn finger	309..329	CDD:275368	9/19 (47%)
		C2H2 Zn finger	337..353	CDD:275368	8/19 (42%)
ZNF721	NP_597731.2	C2H2 Zn finger	83..103	CDD:275368
		COG5048	93..492	CDD:227381	10/35 (29%)
		C2H2 Zn finger	111..131	CDD:275368
		C2H2 Zn finger	139..159	CDD:275368
		zf-H2C2_2	151..176	CDD:290200
		C2H2 Zn finger	167..187	CDD:275368
		C2H2 Zn finger	223..243	CDD:275368
		zf-H2C2_2	235..257	CDD:290200
		C2H2 Zn finger	251..271	CDD:275368
		C2H2 Zn finger	279..299	CDD:275368
		zf-H2C2_2	292..316	CDD:290200
		C2H2 Zn finger	307..327	CDD:275368
		zf-H2C2_2	319..344	CDD:290200
		C2H2 Zn finger	335..355	CDD:275368
		zf-H2C2_2	347..372	CDD:290200
		C2H2 Zn finger	363..383	CDD:275368
		zf-H2C2_2	375..400	CDD:290200
		C2H2 Zn finger	391..411	CDD:275368
		COG5048	442..885	CDD:227381	103/428 (24%)
		C2H2 Zn finger	447..467	CDD:275368	3/7 (43%)
		C2H2 Zn finger	475..495	CDD:275368	6/22 (27%)
		zf-H2C2_2	487..512	CDD:290200	7/27 (26%)
		C2H2 Zn finger	503..523	CDD:275368	5/19 (26%)
		zf-H2C2_2	516..540	CDD:290200	1/23 (4%)
		C2H2 Zn finger	531..551	CDD:275368	0/19 (0%)
		zf-H2C2_2	544..568	CDD:290200	3/23 (13%)
		C2H2 Zn finger	559..579	CDD:275368	4/19 (21%)
		zf-H2C2_2	571..596	CDD:290200	7/24 (29%)
		C2H2 Zn finger	587..607	CDD:275368	3/19 (16%)
		C2H2 Zn finger	615..634	CDD:275368	6/26 (23%)
		C2H2 Zn finger	643..663	CDD:275368	2/19 (11%)
		C2H2 Zn finger	671..691	CDD:275368	4/20 (20%)
		zf-H2C2_2	683..708	CDD:290200	8/36 (22%)
		C2H2 Zn finger	699..719	CDD:275368	3/19 (16%)
		C2H2 Zn finger	755..775	CDD:275368	5/19 (26%)
		zf-H2C2_2	767..789	CDD:290200	11/21 (52%)
		C2H2 Zn finger	783..803	CDD:275368	4/19 (21%)
		zf-H2C2_2	795..820	CDD:290200	10/24 (42%)
		C2H2 Zn finger	811..831	CDD:275368	9/19 (47%)
		zf-H2C2_2	824..848	CDD:290200	12/23 (52%)
		C2H2 Zn finger	839..859	CDD:275368	8/19 (42%)
		zf-H2C2_2	852..876	CDD:290200	5/12 (42%)
		C2H2 Zn finger	867..887	CDD:275368
		C2H2 Zn finger	895..915	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000