DRSC/TRiP Functional Genomics Resources

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Protein Alignment Zif and ZNF681

DIOPT Version :9

Sequence 1:NP_001189188.1 Gene:Zif / 40795 FlyBaseID:FBgn0037446 Length:388 Species:Drosophila melanogaster
Sequence 2:NP_612143.2 Gene:ZNF681 / 148213 HGNCID:26457 Length:645 Species:Homo sapiens


Alignment Length:409 Identity:99/409 - (24%)
Similarity:157/409 - (38%) Gaps:101/409 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    46 YSNLNDREHIPDGI----CKSCKVELNMAYQFREKALRKQMEIEE---YCRELGL-------LDE 96
            :|||...:.|...:    |:.|....|.:..|.:   .|::.|.|   .|.|.|.       |..
Human   182 FSNLTQHKIICTRVNFYKCEDCGKAFNGSSIFTK---HKRIHIGEKSYICEECGKACNQFTNLTT 243

  Fly    97 SDVMMIKEEDGSQQQCDEEMYILEETT------TGEEEHQEE---KGHEEYLEVDT--------- 143
            ..::..:::...:::|.:...:....|      |||..::.|   |...:.|.:.|         
Human   244 HKIIYTRDKLYKREECSKAFNLSSHITTHTIIHTGENPYKREECDKAFNQSLTLTTHKIIHTREK 308

  Fly   144 -SDQQECIGDT------------IEYLEDNYTIE-------MNSDQT--EIVLESEKQY--EE-- 182
             ::.:|| |..            |...|..|..|       .:|..|  :|:...||.|  ||  
Human   309 LNEYKEC-GKAFNQSSHLTRHKIIHTGEKPYKCEECGKAFNQSSHLTRHKIIHTGEKPYRCEECG 372

  Fly   183 ----------------TPSQQLALQEAAKASLKA-------------------RRGRVRRGLNSL 212
                            |..:....:|..||..|:                   :.|:.....::|
Human   373 KAFRQSSHLTTHKIIHTGEKPYKCEECGKAFNKSSHLTRHKSIHTGEKPYQCEKCGKASNQSSNL 437

  Fly   213 TTSDG--TEKGGYICDVCGNFYEKRGRMMEHRRRHDGICQYACELCDAKFQVREQLRKHMYSHTG 275
            |....  ||:..|.|:.||..:.:...:..|:|.|.|...|.||.|...|.....|..|...|||
Human   438 TEHKNIHTEEKPYKCEECGKAFNQFSNLTTHKRIHTGEKPYKCEECGKAFNQSSILTTHKRIHTG 502

  Fly   276 SKPYKCSFCSRQFFYESVLKSHENVHRGIKPYVCKVCDKAFAYAHSLTKHELIHSDIKLYRCDYC 340
            .|.|||..|.:.|:..|.|..|:.:|.|.|||.|:.|.|||.::..|..|::||:..|.|:|:.|
Human   503 EKSYKCEECGKAFYRSSKLTEHKKIHTGEKPYTCEECGKAFNHSSHLATHKVIHTGEKPYQCEEC 567

  Fly   341 NKDFRLLHHMRQHEETKLH 359
            .|.|....|:.:|:  ::|
Human   568 GKAFNQSSHLTRHK--RIH 584

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ZifNP_001189188.1 zf-AD 9..87 CDD:285071 11/47 (23%)
C2H2 Zn finger 225..245 CDD:275368 5/19 (26%)
COG5048 <250..369 CDD:227381 42/110 (38%)
C2H2 Zn finger 253..273 CDD:275368 6/19 (32%)
zf-H2C2_2 266..288 CDD:290200 10/21 (48%)
C2H2 Zn finger 281..301 CDD:275368 6/19 (32%)
zf-H2C2_2 294..318 CDD:290200 12/23 (52%)
C2H2 Zn finger 309..329 CDD:275368 7/19 (37%)
C2H2 Zn finger 337..353 CDD:275368 5/15 (33%)
ZNF681NP_612143.2 KRAB 4..64 CDD:214630
KRAB 4..43 CDD:279668
C2H2 Zn finger 144..164 CDD:275368
C2H2 Zn finger 176..192 CDD:275368 3/9 (33%)
COG5048 198..610 CDD:227381 95/393 (24%)
C2H2 Zn finger 200..220 CDD:275368 5/22 (23%)
C2H2 Zn finger 285..304 CDD:275368 4/18 (22%)
C2H2 Zn finger 313..332 CDD:275368 3/19 (16%)
zf-H2C2_2 324..349 CDD:290200 4/24 (17%)
C2H2 Zn finger 340..360 CDD:275368 4/19 (21%)
zf-H2C2_2 352..377 CDD:290200 7/24 (29%)
C2H2 Zn finger 368..388 CDD:275368 2/19 (11%)
zf-H2C2_2 380..404 CDD:290200 4/23 (17%)
C2H2 Zn finger 396..416 CDD:275368 4/19 (21%)
C2H2 Zn finger 424..444 CDD:275368 3/19 (16%)
zf-H2C2_2 436..461 CDD:290200 8/24 (33%)
C2H2 Zn finger 452..472 CDD:275368 5/19 (26%)
zf-H2C2_2 464..489 CDD:290200 9/24 (38%)
C2H2 Zn finger 480..500 CDD:275368 6/19 (32%)
zf-H2C2_2 493..517 CDD:290200 11/23 (48%)
C2H2 Zn finger 508..528 CDD:275368 6/19 (32%)
zf-H2C2_2 521..545 CDD:290200 12/23 (52%)
C2H2 Zn finger 536..556 CDD:275368 7/19 (37%)
zf-H2C2_2 548..573 CDD:290200 10/24 (42%)
C2H2 Zn finger 564..584 CDD:275368 6/21 (29%)
zf-H2C2_2 576..601 CDD:290200 3/11 (27%)
C2H2 Zn finger 592..612 CDD:275368
C2H2 Zn finger 620..638 CDD:275368
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 626..645
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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