DRSC/TRiP Functional Genomics Resources

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Protein Alignment Zif and ZFP28

DIOPT Version :9

Sequence 1:NP_001189188.1 Gene:Zif / 40795 FlyBaseID:FBgn0037446 Length:388 Species:Drosophila melanogaster
Sequence 2:NP_065879.1 Gene:ZFP28 / 140612 HGNCID:17801 Length:868 Species:Homo sapiens


Alignment Length:379 Identity:86/379 - (22%)
Similarity:131/379 - (34%) Gaps:103/379 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 PQTCRVC---------LAQSERLQRLDEIREEGEESPNEMLIQLLGVS-YSNLNDREHIPDG--- 58
            |..|.||         |...:|:..        .|.|.|..:.....| :::|...:.:..|   
Human   532 PYKCDVCHKSFRYGSSLTVHQRIHT--------GEKPYECDVCRKAFSHHASLTQHQRVHSGEKP 588

  Fly    59 -ICKSCKVELNMAYQFREKALRKQMEIEEYCRELGLLDESDVMMIKEEDGSQQQCDEEMYILEET 122
             .||.|           .||.|:.:.:..:.|          :...|:.....:|.:...|..:.
Human   589 FKCKEC-----------GKAFRQNIHLASHLR----------IHTGEKPFECAECGKSFSISSQL 632

  Fly   123 TTGEEEHQEEKGHEEYLEVDTSDQQECIGDTIEYLEDNYTIEMNSDQTEIVLESEKQYEETPSQQ 187
            .|.:..|..||.:            ||     :.....:|.:.:..|.:.....||.||      
Human   633 ATHQRIHTGEKPY------------EC-----KVCSKAFTQKAHLAQHQKTHTGEKPYE------ 674

  Fly   188 LALQEAAKASLKARRGRVRRGLNSLTTSDGTEKGGYICDVCGNFYEKRGRMMEHRRRHDGICQYA 252
                                                 |..||..:.:...:::|:|.|.|...|.
Human   675 -------------------------------------CKECGKAFSQTTHLIQHQRVHTGEKPYK 702

  Fly   253 CELCDAKFQVREQLRKHMYSHTGSKPYKCSFCSRQFFYESVLKSHENVHRGIKPYVCKVCDKAFA 317
            |..|...|.......:|...|||.:||:|..|.:.|..:|.|..|...|.|.|||.|.||.|||:
Human   703 CMECGKAFGDNSSCTQHQRLHTGQRPYECIECGKAFKTKSSLICHRRSHTGEKPYECSVCGKAFS 767

  Fly   318 YAHSLTKHELIHSDIKLYRCDYCNKDFRLLHHMRQHEETKLHQNAVMLAESMKV 371
            :..||:.|:.|||..|.|.|..|.|.|..:.|:.||:.....:.:....:|.||
Human   768 HRQSLSVHQRIHSGKKPYECKECRKTFIQIGHLNQHKRVHTGERSYNYKKSRKV 821

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ZifNP_001189188.1 zf-AD 9..87 CDD:285071 17/91 (19%)
C2H2 Zn finger 225..245 CDD:275368 5/19 (26%)
COG5048 <250..369 CDD:227381 42/118 (36%)
C2H2 Zn finger 253..273 CDD:275368 4/19 (21%)
zf-H2C2_2 266..288 CDD:290200 8/21 (38%)
C2H2 Zn finger 281..301 CDD:275368 6/19 (32%)
zf-H2C2_2 294..318 CDD:290200 13/23 (57%)
C2H2 Zn finger 309..329 CDD:275368 9/19 (47%)
C2H2 Zn finger 337..353 CDD:275368 5/15 (33%)
ZFP28NP_065879.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..82
KRAB 103..163 CDD:214630
KRAB 103..142 CDD:279668
KRAB 232..288 CDD:214630
KRAB 232..266 CDD:279668
COG5048 417..806 CDD:227381 83/362 (23%)
zf-C2H2 420..442 CDD:278523
C2H2 Zn finger 422..442 CDD:275368
zf-H2C2_2 434..458 CDD:290200
C2H2 Zn finger 450..470 CDD:275368
zf-H2C2_2 462..487 CDD:290200
C2H2 Zn finger 478..496 CDD:275368
C2H2 Zn finger 507..527 CDD:275368
zf-H2C2_2 520..544 CDD:290200 4/11 (36%)
C2H2 Zn finger 535..555 CDD:275368 5/19 (26%)
zf-H2C2_2 547..572 CDD:290200 5/32 (16%)
C2H2 Zn finger 563..583 CDD:275368 2/19 (11%)
zf-H2C2_2 575..600 CDD:290200 7/35 (20%)
C2H2 Zn finger 591..611 CDD:275368 7/40 (18%)
zf-H2C2_2 603..627 CDD:290200 3/33 (9%)
C2H2 Zn finger 619..639 CDD:275368 3/19 (16%)
zf-H2C2_2 632..656 CDD:290200 6/40 (15%)
C2H2 Zn finger 647..667 CDD:275368 3/24 (13%)
zf-H2C2_2 659..684 CDD:290200 8/67 (12%)
C2H2 Zn finger 675..695 CDD:275368 5/19 (26%)
zf-H2C2_2 687..710 CDD:290200 7/22 (32%)
C2H2 Zn finger 703..723 CDD:275368 4/19 (21%)
zf-H2C2_2 718..740 CDD:290200 9/21 (43%)
C2H2 Zn finger 731..751 CDD:275368 6/19 (32%)
zf-H2C2_2 743..768 CDD:290200 13/24 (54%)
C2H2 Zn finger 759..779 CDD:275368 9/19 (47%)
zf-H2C2_2 771..796 CDD:290200 12/24 (50%)
C2H2 Zn finger 787..807 CDD:275368 7/19 (37%)
C2H2 Zn finger 815..835 CDD:275368 3/7 (43%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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