DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment myh4 and Mhc

DIOPT Version :9

Sequence 1:NP_001001244.1 Gene:myh4 / 407946 XenbaseID:XB-GENE-989283 Length:1935 Species:Xenopus tropicalis
Sequence 2:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster


Alignment Length:1913 Identity:1067/1913 - (55%)
Similarity:1424/1913 - (74%) Gaps:17/1913 - (0%)


- Green bases have known domain annotations that are detailed below.


 Frog    20 EKERLEAQSKPFDAKNTVFVDDVKELYVKGMVTAREDGKITVKTDDGRTVTVKENQIYPQNPPKF 84
            |:.|:: ||||:|:|.:.::.|.||.|:.|.:.|.:...::|....|....:|..::...|||||
  Fly    22 EQRRID-QSKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGLQGGEVRDIKSEKVEKVNPPKF 85

 Frog    85 DKIEDMAMMTHLNEASVLYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYNPEVVAGYRGKKRME 149
            :||||||.||.||...||:||::||.|.:|||||||||..:||||..|||.......||||:|.|
  Fly    86 EKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNE 150

 Frog   150 APPHIFSLSDNAYQAMLTDRENQSVLITGESGAGKTVNTKRVIQYFATIAALGDKKKESSNSLQG 214
            .|||||::||.||..|||:..|||:|||||||||||.|||:||.||||:.|  .||.:.:...:|
  Fly   151 VPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGA--SKKTDEAAKSKG 213

 Frog   215 NLEDQIIQANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLSSADIETYLLEKSRVTFQLSA 279
            :||||::|.||:|||||||||||||||||||||||||||.||||:.||||||||||:||..|.|.
  Fly   214 SLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSL 278

 Frog   280 ERSYHIFYQILTNKKPEIVEMLLLTTNPYDYPSISQGELVVKSINDEEELMATDSAIDVLGFNQE 344
            ||||||||||::...|.:.::.|||.|.|||..:|||::.|.||:|.||...||.|.|:|||.::
  Fly   279 ERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILGFTKQ 343

 Frog   345 EKMGIYKMTGAVMHHGNLKFKQKQREEQAEPDSTEVADKIAYLLGLNSADLLKGLCYPRVKVGNE 409
            ||..:|::|.||||.|.:||||:.||||||.|..|...:::.|.|.::|:|.|.|..||:|||||
  Fly   344 EKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKVGNE 408

 Frog   410 FVTKGQTVPQVYNSVGALCKSVFEKLFLWMVTRINQQLDTKQPRQFFIGVLDIAGFEIFDFNSLE 474
            |||:|:.|.||.||:|||||.||::||.|:|.:.|:.|||:|.||.|||||||||||||::|..|
  Fly   409 FVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYNGFE 473

 Frog   475 QLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIDWEFIDFGMDLAACIELIEKPLGIFSILEEECM 539
            ||||||||||||||||||||||||||||:|||||.||||||||.|||:|||||:||.||||||.|
  Fly   474 QLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKPMGILSILEEESM 538

 Frog   540 FPKATDTSFKNKLYEQHLGKCKNFEKPKPGK-GKAEAHFSLVHYAGTVDYNISGWLEKNKDPLNE 603
            ||||||.:|..||...||||...|:||||.| |:..|||::.||||.|.|||:|||||||||||:
  Fly   539 FPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLND 603

 Frog   604 SVVQLYQKSSVKLLSLLYSSYAATDGDAGG----KGGKKKKGSSFQTVSGLFRENLNKLMTNLRS 664
            :||..::||..|||..:::.:|   |.:||    |||:.|||..|.|||..::|.||.|||.|||
  Fly   604 TVVDQFKKSQNKLLIEIFADHA---GQSGGGEQAKGGRGKKGGGFATVSSAYKEQLNSLMTTLRS 665

 Frog   665 THPHFVRCLIPNETKTPGIMDNHLLIHQLRCNGVLEGIRICRKGFPSRILYGDFKQRYKVLNASA 729
            |.||||||:||||.|.||::|.||::|||.||||||||||||||||:|::|.|||.|||::....
  Fly   666 TQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKIMCPKL 730

 Frog   730 IPEGQFID-SKKACEKLLGSIDVDHTQYKFGHTKVFFKAGLLGTLEEMRDEKLAQLITRTQALCR 793
            :   |.:: .|||.|.::..||:...||:.|:|||||:||:||.:||.|||:|.::::..||..|
  Fly   731 L---QGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWAR 792

 Frog   794 GYLMRLEFTKMMERREAIYVIQYNLRSFMNVKHWPWMKLYFKIKPLLKSAETEKEMANMKEEFEK 858
            |||.|..|.|:.|:|.|:.|:|.|||.::.::.|||.||:.|:||||..:..|.|:|.::|:.:|
  Fly   793 GYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEEKAKK 857

 Frog   859 TKEALVKAEAR-KKELEEKMVAMLQEKNDLVLQVQSESETLADSEERCEGLIKVKIQLESKIKEL 922
            .:| |..||.: :||||.....:|.||..|:..:..|...|.|.:||...|...|..||::::::
  Fly   858 AEE-LHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKNDLENQLRDI 921

 Frog   923 TERLEDEEESNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAVLDE 987
            .|||..||::..:|..:|:|.:.|.|.|||||:||||.:.|.|::|...:::::||.:|:|..||
  Fly   922 QERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLNDEIAHQDE 986

 Frog   988 NISKLSKEKKALQEAHQQTLDDLQAEEDKVSSLSKAKTKLEQQVDDLEGSLEQEKKLRLDLERAK 1052
            .|:||:||||...|.:|:|.::|||.|||::.|:|.|.||||.:|:||.|||:|||:|.|:|::|
  Fly   987 LINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLEREKKVRGDVEKSK 1051

 Frog  1053 RKLEGDLKLTQETVMDLENDKQQTEEKLKKKDFEISQLQGKIEDEQSLGTQLQKKIKELQARIEE 1117
            ||:|||||||||.|.|||.:|::.|:.:::||.|:|.:..|:||||.:..:.|::||||||||||
  Fly  1052 RKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQRQIKELQARIEE 1116

 Frog  1118 VEEEIEAERAARAKVEKQRADLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKLRRDLEEAT 1182
            :|||:||||.||||.|||||||:|||||:.|||||||||||||||:|||||||..|||||||||.
  Fly  1117 LEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAELSKLRRDLEEAN 1181

 Frog  1183 LQHEATAGALRKKHADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDLASNLENVSKSKANLEK 1247
            :|||:|...|||||.|:|||:.||:|.|.::|.|.||||:|...:::||.:.:::::..||..||
  Fly  1182 IQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGVDHITNEKAAQEK 1246

 Frog  1248 VNRVIEDQLSEVKAKDDEHQRLLNDLSTQKARLQTETGELSRQLEERESLISQLSRGKQGFTQQV 1312
            :.:.::..|:||::|.||..|.|||....|.:|..|..:|.|||||.||.:||||:.|...|.|:
  Fly  1247 IAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKISLTTQL 1311

 Frog  1313 EELKRQLEEETKAKNALAHALQSARHDCDLLREQFEEEQEAKAELQRSLSKANGEVSQWRTKYET 1377
            |:.||..:||::.:..|....::..||.|.||||.|||.|.||:|||.|||||.|...||:|||:
  Fly  1312 EDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKANAEAQVWRSKYES 1376

 Frog  1378 DAIQRTEELEEAKKKLAQRLQDAEEQVEAVNSKCASLEKTKQRLQSEVEDLMVDVERANSAAAAL 1442
            |.:.|:|||||||:||..||.:|||.:|::|.||..||||||||.:|||||.::|:|||:.|.|.
  Fly  1377 DGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVEDLQLEVDRANAIANAA 1441

 Frog  1443 DKKQRNFDKVLVEWKQKYEEGQAELEAALKESRSLSTEIFKMKNAYEEALEHVETLKRENKNLQQ 1507
            :|||:.|||::.|||.|.::..|||:|:.||.|:.|||:|::|.||||..|.:|.::||||||..
  Fly  1442 EKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRRENKNLAD 1506

 Frog  1508 EISDLTEQIGESGKSVVELEKAKKQVEQEKNDLQAALEEAEGSLEHEEAKILRIQLELNQVKSEV 1572
            |:.||.:||||.|:::.|:|||:|::|.||::|||||||||.:||.||.|:||.||||:||:.|:
  Fly  1507 EVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLELSQVRQEI 1571

 Frog  1573 DRKIAEKDEEIEQLKRNSQRSIDTMQSTLDSEIRSRNDALRLKKKMEGDLNELEIQLGHANRQAS 1637
            ||:|.||:||.|..::|.||::|:||::|::|.:.:.:|||:|||:|.|:|||||.|.|||:..:
  Fly  1572 DRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALDHANKANA 1636

 Frog  1638 EAQKQLRNVQGQFKETQLQLDEAIRAQEDLKEQVAVTERRNNLFQAEIEENRAGLEQTERSRKIA 1702
            ||||.::..|.|.|:.|..|:|..||::|.:||:.::|||.|..|.|:||:|..|||.:|.|:.|
  Fly  1637 EAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEESRTLLEQADRGRRQA 1701

 Frog  1703 EQELLDASERLQLLHSQNTSLINSKKKLESDICQLQNEAEEAVQEARNAEEKAKKAITDAALMAE 1767
            ||||.||.|:|..:.:||.|:..:|:||||::..|.::.:|.:.||:|:|||||||:.|||.:|:
  Fly  1702 EQELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSEEKAKKAMVDAARLAD 1766

 Frog  1768 ELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLAMKGGKKQLQKLESRVRELENELDNEQKH 1832
            ||:.|||.:...|:::|.|||.:|:||.||||||..|:|||||.:||||.||||||||||.||:.
  Fly  1767 ELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQKLEQRVRELENELDGEQRR 1831

 Frog  1833 GVEAVKGVRKYERRVKELTYQTEEDKKNILRLQDLVDKLQSKVKAYKRQAEEAEEQANTHLGRFR 1897
            ..:|.|.:||.|||||||::|:|||:||..|:||||||||.|:|.||||.|||||.|..:|.:||
  Fly  1832 HADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIEEAEEIAALNLAKFR 1896

 Frog  1898 KVQHELEEAEERADIAESQVNKLRTKSR 1925
            |.|.||||||||||:||..::|.|.|.|
  Fly  1897 KAQQELEEAEERADLAEQAISKFRAKGR 1924

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
myh4NP_001001244.1 Myosin_N 34..72 CDD:397036 9/37 (24%)
MYSc_class_II 99..766 CDD:276951 418/672 (62%)
Myosin_tail_1 846..1923 CDD:396244 577/1077 (54%)
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 8/36 (22%)
MYSc 81..777 CDD:214580 440/703 (63%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 418/672 (62%)
Myosin_tail_1 842..1897 CDD:279860 560/1055 (53%)
V_Alix_like 1557..1877 CDD:187408 173/319 (54%)
ATP-synt_B <1671..1771 CDD:304375 49/99 (49%)
TMPIT 1739..>1825 CDD:285135 51/85 (60%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 1116 1.000 Domainoid score I21
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 2089 1.000 Inparanoid score I44
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D41153at33208
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 1 1.000 - - otm48957
Panther 1 1.100 - - O PTHR45615
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2660
SonicParanoid 1 1.000 - - X58
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
88.190

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