Protein Alignment CG9727 and RFX7

DIOPT Version :10

• Sequence 1: NP_001262317.1
• Gene: CG9727 / 40794
• FlyBaseID: FBgn0037445
• Length: 1329
• Species: Drosophila melanogaster
• Sequence 2: XP_054234606.1
• Gene: RFX7 / 64864
• HGNCID: 25777
• Length: 1556
• Species: Homo sapiens
• Alignment Length: 1557
• Identity: 325/1557 - (20%)
• Similarity: 516/1557 - (33%)
• Gaps: 523/1557 - (33%)

  Fly    90 PASAQISPTSHTHVPVPVATPSGFV-------------PPPFSNATSASGGVSTSVLTPNPFATA 141
            |....::|...:..|.....|.|::             |||...|....|..     .|.|...|
Human     2 PDRGALNPAPDSRFPFKTELPKGWLIPTGVLLWGLLKTPPPRFPALHQPGRT-----PPGPQRRA 61

  Fly   142 SANAAGLAFANAFSFSTAQQLGLGKIMHAMGGATAGVPSAPVPVTTT------------------ 188
            |.                          |...|....|.||:|....
Human    62 SL--------------------------ARWPAPPSAPCAPIPARRARGPHTLVHAPRRSAMAEE 100

  Fly   189 ---PATAAPSTPTIAGPRHPNEGV--PAASGVINSTIAENVMNALSNSNSAGSVPSEEKMRRVLQ 248
               |....|.......|..||.||  ||....:..|.|..:.:.:.||              :.:
Human   101 QQQPPPQQPDAHQQLPPSAPNSGVALPALVPGLPGTEASALQHKIKNS--------------ICK 151

  Fly   249 VIETSLDDNAKLQISQILERVSGLKPIEKLFLYLRLP-----GECADTDPLRQPQNPL-GTRSEI 307
            .:::.:|        .||:.|.....:|||:|||:||     ||.:|       ||.: .:|::.
Human   152 TVQSKVD--------CILQEVEKFTDLEKLYLYLQLPSGLSNGEKSD-------QNAMSSSRAQQ 201

  Fly   308 NHTINWVRSHLEHDAQVSIPKQDVYNDYIAYCERLSIKPLSTADFGKVMKQVFPGVRPRRLGTRG 372
            .|..:|:|:.||...:.|:|||:||::|.:||:.|...|||.|||||:||.|||.::.|||||||
Human   202 MHAFSWIRNTLEEHPETSLPKQEVYDEYKSYCDNLGYHPLSAADFGKIMKNVFPNMKARRLGTRG 266

  Fly   373 NSRYCYAAMRKTTKLTPPQLPQLCKTEQIVAGDSNSDPSQLTSASSLGGLPSTGGD--SECWDVV 435
            .|:|||:.:||...:..|.||.|         |.:.....|..|...|.|.:...:  |....:|
Human   267 KSKYCYSGLRKKAFVHMPTLPNL---------DFHKTGDGLEGAEPSGQLQNIDEEVISSACRLV 322

  Fly   436 RSWAEKLLNTKLESVADLSS-RIKSN--------------------------NATVSTKKYTPRE 473
            ..||:|:|:...::|.:|:. .:||:                          :|.:.|.:....:
Human   323 CEWAQKVLSQPFDTVLELARFLVKSHYIGTKSMAALTVMAAAPAGMKGITQPSAFIPTAESNSFQ 387

  Fly   474 PKEKRVLADIGPLKKRRKKKRKGSTSSESSCNQLVTGQDAGSSQEASDEQILKIKQEIIDSPIHP 538
            |:.|.:.:.|...::.::|.:|  ...|......:.|:.|....|::....:........|.:.|
Human   388 PQVKTLPSPIDAKQQLQRKIQK--KQQEQKLQSPLPGESAAKKSESATSNGVTNLPNGNPSILSP 450

  Fly   539 QQPPIGYLQQVTPMNLATDQRSSSAVRNLTP------KILEMGSPAVVLTQQEV----------- 586
            |  |||.:....|..:.. ||:...|.:.:|      |:|.:....|....|.|
Human   451 Q--PIGIVVAAVPSPIPV-QRTRQLVTSPSPMSSSDGKVLPLNVQVVTQHMQSVKQAPKTPQNVP 512

  Fly   587 -SPTGIVIKDEVEDYTSNIFCKKVL-KAQQTKGFWANSPSS--GTTSGVGLLVPPT--------- 638
             ||.|        |.::.....::| |...|......||::  .|:|.:...|.|.
Human   513 ASPGG--------DRSARHRYPQILPKPANTSALTIRSPTTVLFTSSPIKTAVVPASHMSSLNVV 569

  Fly   639 -ITTTSATPPPPNS----------------ETSPVP----GPGLSMGPPSQMMSTSSVSPSSTVD 682
             :||.|.||...|:                |:..||    |..:|:..|....|::..:.:..|.
Human   570 KMTTISLTPSNSNTPLKHSASVSSATGTTEESRSVPQIKNGSVVSLQSPGSRSSSAGGTSAVEVK 634

  Fly   683 TTPKVASRNQMMILRAKRLMAAENAALAAA-------------EDSGL--PENLGLPRERVISIC 732
            ..|:.:|...       .:...||:..|.|             .|..|  |.|.|:...:...:|
Human   635 VEPETSSDEH-------PVQCQENSDEAKAPQTPSALLGQKSNTDGALQKPSNEGVIEIKATKVC 692

  Fly   733 NMD---KHELDDYFLPGEDEENSEEPDNELLQYFQMGDAEEKQLNSLDAAEQN------KNPQEP 788
            :..   |...:: .|||....|::                  ...:|..|.||      .:|...
Human   693 DQRTKCKSRCNE-MLPGTSTGNNQ------------------STITLSVASQNLTFTSSSSPPNG 738

  Fly   789 PTMGSAPEAMPAPGRGAAVVAAAAAMLAPVPAP--SMLPAQAGVGSASASLALMSKKHQQQNQHQ 851
            .::...|:......|...........:.||..|  ..|.|....|....|:     |..|:..|.
Human   739 DSINKDPKLCTKSPRKRLSSTLQETQVPPVKKPIVEQLSAATIEGQKQGSV-----KKDQKVPHS 798

  Fly   852 NLQLQRS---KQLPLISNNKRKISLSNASSNGSNK--NCIFLPISPNTNGSVTTPTATGSSNPSQ 911
            . :.:.|   .|:|      .|:|::.:|..|:|:  |...|.||.:.....|||:::
Human   799 G-KTEGSTAGAQIP------SKVSVNVSSHIGANQPLNSSALVISDSALEQQTTPSSS------- 849

  Fly   912 NCFASPGLTRMKQRPNLLSKQQS----LDCDNRDPMIGA-HRKGRGYVYSYPTSTSASAPPSPSI 971
                          |::..|.:.    ||.|::.  :|: :..|...:.......|||......|
Human   850 --------------PDIKVKLEGSVFLLDSDSKS--VGSFNPNGWQQITKDSEFISASCEQQQDI 898

  Fly   972 ----LPQWMCRN------WSLGGGNISSFAD--------------SSHSADPLVNQNSM-DLETS 1011
                :|:....|      |.|.|....:::.              .:||:|.|..|:.: :.|.|
Human   899 SVMTIPEHSDINDLEKSVWELEGMPQDTYSQQLHSQIQESSLNQIQAHSSDQLPLQSELKEFEPS 963

  Fly  1012 LALTGEN---------------ELDTSEMQ-----------------RSQSV----PLSQLQRRG 1040
            ::.|.|:               ||...|.|                 :||||    |:
Human   964 VSQTNESYFPFDDELTQDSIVEELVLMEQQMSMNNSHSYGNCLGMTLQSQSVTPGAPM------- 1021

  Fly  1041 SQQSPSLNFYSE-NSN------------------------------SQQSAPLKETGLLYEEVEV 1074
            |..:.|.:||.. :||                              ||..:.......|.:...|
Human  1022 SSHTSSTHFYHPIHSNGTPIHTPTPTPTPTPTPTPTPTPTSEMIAGSQSLSRESPCSRLAQTTPV 1086

  Fly  1075 DSLLSANFTRKFNSITQQTATTCSSSA----------------GSSSGYSSGGSAGIVSRSVPST 1123
            ||.|.::......:    ..:.||||.                .||..|.   .|.|||.| |..
Human  1087 DSALGSSRHTPIGT----PHSNCSSSVPPSPVECRNPFAFTPISSSMAYH---DASIVSSS-PVK 1143

  Fly  1124 PL-----PHQQQNSLTSLNGGGGAASSGGGVMGIGNGGNCGVG----------------NGFFTI 1167
            |:     .|..:..|..:|         .|..|:||....|.|                :.|...
Human  1144 PMQRPMATHPDKTKLEWMN---------NGYSGVGNSSVSGHGILPSYQELVEDRFRKPHAFAVP 1199

  Fly  1168 SDSF--------------------NWEGSTSNNS--QLGYAHSYSARNSLDISKSMPTTPIATQR 1210
            ..|:                    ..:|:|.||:  |.|:|......|.       .|...|:..
Human  1200 GQSYQSQSRHHDTHFGRLTPVSPVQHQGATVNNTNKQEGFAVPAPLDNK-------GTNSSASSN 1257

  Fly  1211 FR---YSPAEVHRDFLINGNT---IDSLPSSAFAGGVVPTDPTLALSTDTLIDDSAPSSADVVEA 1269
            ||   .||| |||...::|:|   :.::|.|    .|.|.              .:|
Human  1258 FRCRSVSPA-VHRQRNLSGSTLYPVSNIPRS----NVTPF--------------GSP-------- 1295

  Fly  1270 MIGVTGILDDFXNLHEEKAQGEIEISEQQEP-DAVEENEVQSAAKEDAN---VVACLLQHVD 1327
               ||..:..| |:|.:.....|....|..| ..:.:....:|.::.||   :...||..:|
Human  1296 ---VTPEVHVFTNVHTDACANNIAQRSQSVPLTVMMQTAFPNALQKQANSKKITNVLLSKLD 1354

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9727	NP_001262317.1	PHA03247	<40..207	CDD:223021	24/150 (16%)
		RFX_DNA_binding	307..385	CDD:460512	41/77 (53%)
RFX7	XP_054234606.1	RFX5_N	139..196	CDD:375753	19/85 (22%)
		RFX_DNA_binding	201..279	CDD:460512	41/77 (53%)
		Herpes_BLLF1	<354..664	CDD:282904	60/329 (18%)
		MSCRAMM_ClfA	564..>841	CDD:468110	60/314 (19%)