DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9727 and RFX2

DIOPT Version :9

Sequence 1:	NP_001262317.1	Gene:	CG9727 / 40794	FlyBaseID:	FBgn0037445	Length:	1329	Species:	Drosophila melanogaster
Sequence 2:	NP_000626.2	Gene:	RFX2 / 5990	HGNCID:	9983	Length:	723	Species:	Homo sapiens

Alignment Length:	451	Identity:	103/451 - (22%)
Similarity:	156/451 - (34%)	Gaps:	153/451 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSEKHGQLGAQWTKSAA--PAATTAPVSNSIPIPQPIPVALPLQKPNANPYGNCSLQPADIVYSA 63
            |....|  ||....|.|  |:|...||..|   ||.:.|    |..::||.|
Human     1 MQNSEG--GADSPASVALRPSAAAPPVPAS---PQRVLV----QAASSNPKG------------- 43

  Fly    64 TRFQGPAIHAKGSPLTITPVGPVGGAPASAQISPTSHTHVPVPVATPSGFVPPPFSNATSASGGV 128
                     |:..|:::..|..|     ..|:.|..|.: |..|....|      .:|...:|.:
Human    44 ---------AQMQPISLPRVQQV-----PQQVQPVQHVY-PAQVQYVEG------GDAVYTNGAI 87

  Fly   129 STS-VLTPNPFATASANAAGLAFANAFSFSTAQQLGLGKIMHAMGGATAGVPSAPVPVTTTPATA 192
            .|: ...|.|...|.::.|                   ....|.|||...|             |
Human    88 RTAYTYNPEPQMYAPSSTA-------------------SYFEAPGGAQVTV-------------A 120

  Fly   193 APSTPTIAGPRHPNEGVP---AASGVINSTIAENVMNALSNSNSAGSVPSEEKMRRVLQVIETSL 254
            |.|.|.:  |.|...|:.   ..|.:::|..|..:...:.::..:.:..|......:...||
Human   121 ASSPPAV--PSHSMVGITMDVGGSPIVSSAGAYLIHGGMDSTRHSLAHTSRSSPATLEMAIE--- 180

  Fly   255 DDNAKLQISQ-ILERVSGLKPIEKLFLYLRLPGECADTDPLRQPQNPLGTRSEINHTINWVRSHL 318
                .||.|: |....|||                                  :|..:.|:..:.
Human   181 ----NLQKSEGITSHKSGL----------------------------------LNSHLQWLLDNY 207

  Fly   319 EHDAQVSIPKQDVYNDYIAYCERLSIKPLSTADFGKVMKQVFPGVRPRRLGTRGNSRY------- 376
            |....||:|:..:||.|:.:|:...:.|::.|.|||:::.||.|:|.|||||||||:|
Human   208 ETAEGVSLPRSSLYNHYLRHCQEHKLDPVNAASFGKLIRSVFMGLRTRRLGTRGNSKYHYYGIRL 272

  Fly   377 -------------CYAAMRKTTKLTPPQLPQLCKTEQIVAGDS------NSDPSQLTSASS 418
                         .|.|||:......|:.....||:.:  |||      :|.|.|..:..|
Human   273 KPDSPLNRLQEDTQYMAMRQQPMHQKPRYRPAQKTDSL--GDSGSHSGLHSTPEQTMAVQS 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9727	NP_001262317.1	RFX_DNA_binding	307..383	CDD:280427	32/95 (34%)
RFX2	NP_000626.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..46		19/75 (25%)
		RFX1_trans_act	30..153	CDD:282451	38/194 (20%)
		RFX_DNA_binding	200..272	CDD:280427	28/71 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	292..332		10/42 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	688..723
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3712
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D346630at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910