DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9727 and rfx2

DIOPT Version :9

Sequence 1:	NP_001262317.1	Gene:	CG9727 / 40794	FlyBaseID:	FBgn0037445	Length:	1329	Species:	Drosophila melanogaster
Sequence 2:	NP_001013296.1	Gene:	rfx2 / 503590	ZFINID:	ZDB-GENE-050227-4	Length:	734	Species:	Danio rerio

Alignment Length:	649	Identity:	130/649 - (20%)
Similarity:	210/649 - (32%)	Gaps:	220/649 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 GAQWTKSAAPAATTAPVSNSIPIPQPIPVALPLQKPNANPYGNCSLQPADIVYSATRFQGPAIHA 73
            |...|.|.....|:  .|...|:.||:|.:                |...:|      |......
Zfish     6 GGSETPSTVALRTS--TSAQAPVVQPVPAS----------------QQRVLV------QATGSSQ 46

  Fly    74 KGSPLTITPVGPVGGAPASAQISPTSHTHVPVPVATPSGFVPPPFSNATSASGGVSTSVLTPNPF 138
            ||:.:...||..|...|  .|:....|.|                |.......|  ...:.||..
Zfish    47 KGAQVQQLPVPRVQQVP--QQVQQVQHYH----------------SQQVQYVEG--AEAVYPNGT 91

  Fly   139 ATASANAAGLAFANAFSFSTAQQLGLGKIMHAMGGATAGVPSAPVPVTTTPATAAPSTPTIAGPR 203
            ..|           |:|::...||      :..|..:|...|.......|...::...||
Zfish    92 IRA-----------AYSYNPESQL------YGQGSGSAYFDSQAGGAQVTTVVSSGGVPT----- 134

  Fly   204 HPNEGVP---AASGVINSTIAENVMNALSNSNSAGSVPSEEKMRRVLQVIETSLDDNAKLQISQI 265
            |...|:.   ..|.:|:|..|..:...:.......|              .:|...:|.|:::
Zfish   135 HGMVGIAMDVGGSQIISSGSAYLIHGGMEGGRHHTS--------------HSSRSSSAMLEMA-- 183

  Fly   266 LERVSGLKPIEKLFLYLRLPGECADTDPLRQPQNPLGTR--SEINHTINWVRSHLEHDAQVSIPK 328
                     ||.|                 |....:.|.  |.:|..:.|:..:.|....||:|:
Zfish   184 ---------IENL-----------------QKSEGIATHKSSLLNSHLQWLLDNYETAEGVSLPR 222

  Fly   329 QDVYNDYIAYCERLSIKPLSTADFGKVMKQVFPGVRPRRLGTRGNSRYCYAAMRKTTKLTPPQ-L 392
            ..:||.|:.:|:...:.|::.|.|||:::.||.|:|.|||||||||:|.|..:|    |.|.. |
Zfish   223 SSLYNHYLRHCQEQKLDPVNAASFGKLIRSVFMGLRTRRLGTRGNSKYHYYGIR----LKPDSPL 283

  Fly   393 PQLCKTEQIVA---------------------GDS--------NSDPSQLTSAS----------- 417
            .::.:..|.:|                     |||        :|.|.|..:|.
Zfish   284 NRMQEDTQYMAMRQTPVHQKQRFKPFHKMDGMGDSLNSGSQHLSSTPEQSVAAQCQHHQQYIDVS 348

  Fly   418 ---------SLGGLPSTGGDS-------------EC---WDVVRS----WAEKLLNTKLESVA-- 451
                     .||..|.....|             .|   .|||.:    ..|||..|...|.|
Zfish   349 HVLPPFPSLDLGSCPLPESISMTDVKKLQSSYRIHCEATLDVVMNLQFHLIEKLWQTFWHSTAPS 413

  Fly   452 -DLSSRIKSNNATVSTKKYTPREPKEKRVLADIGPLKKRRKKKRKGSTSSESSCNQLVTGQDAGS 515
             |.::.|.::...|...:..||:  :...|....|:|:..:           ||:.::.
Zfish   414 SDGATTIPNSEEDVEDIRGFPRD--KLITLCKYEPIKQWMR-----------SCDHILY------ 459

  Fly   516 SQEASDEQILKIKQEIIDSPIHPQQPPIGYLQQVTPMNLATDQRSSSAVRNLTPKILEMGSPAV 579
                  :.:::|   :|...:.|  .|....|.:.....:.:...:||:.|..|:|:...:..|
Zfish   460 ------QALVEI---LIPDVLRP--VPSTLTQAIRNFAKSLEGWLTSAMTNFPPEIISTKAAVV 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9727	NP_001262317.1	RFX_DNA_binding	307..383	CDD:280427	30/75 (40%)
rfx2	NP_001013296.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31		8/26 (31%)
		RFX1_trans_act	11..158	CDD:282451	40/212 (19%)
		RFX_DNA_binding	205..277	CDD:280427	30/75 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	694..722
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D346630at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010