Protein Alignment CG9727 and rfx4

DIOPT Version :10

• Sequence 1: NP_001262317.1
• Gene: CG9727 / 40794
• FlyBaseID: FBgn0037445
• Length: 1329
• Species: Drosophila melanogaster
• Sequence 2: NP_991275.2
• Gene: rfx4 / 403016
• ZFINID: ZDB-GENE-040909-2
• Length: 735
• Species: Danio rerio
• Alignment Length: 898
• Identity: 175/898 - (19%)
• Similarity: 272/898 - (30%)
• Gaps: 356/898 - (39%)

  Fly   310 TINWVRSHLEHDAQVSIPKQDVYNDYIAYCERLSIKPLSTADFGKVMKQVFPGVRPRRLGTRGNS 374
            |:.|:..:.|....|.||:..:|..|:.:||:|..:|::.|.|||:::|.||.:..|||||||.|
Zfish    61 TLQWLEENYEIAEGVCIPRSALYMHYLDFCEKLDSQPVNAASFGKIIRQQFPQLTTRRLGTRGQS 125

  Fly   375 RYCYAAMRKTTKLTPPQLPQLCKTEQIVAGDSNSDPSQLTSASSLGGLPSTGGDSECWDVVRS-- 437
            :|.|..                    |...:|                      |:.:||:.|
Zfish   126 KYHYYG--------------------IAVKES----------------------SQYYDVMYSKK 148

  Fly   438 ---WAEKLLNTKLESVADLSSRIKSNNATVSTKKYTPREPKEKRVLADIGPLKKRRKKKRKGSTS 499
               |.               :.......|..|..|:||. |...:|.|...:|
Zfish   149 GAAWV---------------NETGKKEVTKQTVAYSPRS-KLGTLLPDFPNVK------------ 185

  Fly   500 SESSCNQLVTGQDAGSSQEASDEQILKIKQEIIDSPIHPQQPPIGYLQQVTPMNLATDQRSSSAV 564
                        |........:|   |:...|:....|.|:    .|..|...|.  |:..|..:
Zfish   186 ------------DLNLPASLPEE---KVSTFIMMYRTHCQR----ILDTVIRANF--DEVQSFLL 229

  Fly   565 ---RNLTPKILE-MGSPAVVLTQQEVSPTGIVIKDEVEDYTSNI--FCKKVLKAQQTKGFWANSP 623
               :.:.|.:|. :||..||                      ||  .|..:|       :.|.|
Zfish   230 HFWQGMPPHMLPVLGSSTVV----------------------NIVGVCDSIL-------YKAIS- 264

  Fly   624 SSGTTSGVGLLVPPTITTTSATPPPPNSETSPVPGPGLSMGPPSQMMSTSSVSPSSTVDTTPKVA 688
                    |:|:|   |...|.|.
Zfish   265 --------GVLMP---TVLQALPD----------------------------------------- 277

  Fly   689 SRNQMMILRAKRLMAAENAALAAAEDSGLPENLG-------------LPRERVIS-ICNMDK--- 736
            |..|::...||:|......||     ..|||||.             |.|:..:: :|...:
Zfish   278 SLTQVIRKFAKQLDEWLKVAL-----HDLPENLRNIKFELSRRFSQILKRQTSLNHLCQASRTVI 337

  Fly   737 HELDDYFLPGEDEENSEEPDNELLQYFQMGDAEEKQ-------LNSLDAAEQNKNPQEP------ 788
            |..|..|...||..|.:.........:.|.|:.|.|       ....|...::::|.|.
Zfish   338 HSADITFQMLEDWRNVDLNSITKQTLYTMEDSREDQRRLIIQLYQEFDRLLEDQSPIEAYIEWLD 402

  Fly   789 --------PTMGSAPEAMPAPGR---------GAAVVAAAAAMLAPVPAPSMLPAQAGVGS---- 832
                    ...|..|.::....:         |..|:.......||           ..||
Zfish   403 SMVERCVVRVAGKRPGSLKRVAQQFLLMWSCFGTRVIRDMTLHSAP-----------SFGSFHLI 456

  Fly   833 ----ASASLALMSKKHQQQNQHQNLQLQRSKQLPLISNNKRKISLSNASSNGSNKNCIFLPISP- 892
                ....|.|:...|.|:..::.::..:.:..|..:..:..:..|..:|...      .|.||
Zfish   457 HLMFDDYVLYLLESLHCQERANELMRAMKGEGAPADTGEELMLMSSTPTSTSP------APYSPA 515

  Fly   893 NTNGSVTTPTATGSSNPSQNCFASPGLTRMKQRPNLLSKQQSLDCDNRDPMIGAHRKGRGYVYS- 956
            .:..||..| |.||.|.:|    ||..|.:......:                     :.|.:|
Zfish   516 KSVHSVGVP-AVGSPNSAQ----SPEYTSISATTGAV---------------------QSYTWSL 554

  Fly   957 -YPTSTSASAPPSPSILPQWMC-----------------------RNWSLGGGNISSFADSSHSA 997
             |..:||..:|..|.  .|..|                       .:...|..|.||:|:..|.|
Zfish   555 TYTVTTSGGSPTEPG--SQLSCMRGGPALHGSSSAHRMPVYPHRDEHGYTGSYNYSSYANQHHHA 617

  Fly   998 DPLVNQNSMDLETSLALTGENELDTSEMQRSQSVPL--SQLQRRGSQQSPSLNFYSENS--NSQQ 1058
              :.:|.|       :||.|..|.|         ||  |...|..:|       |..||  :..:
Zfish   618 --IQSQYS-------SLTHEAGLPT---------PLHYSSYHRTSAQ-------YPLNSQMSRME 657

  Fly  1059 SAPLKETGLLYEEVEVDSLLSANFTRKFNSITQQTATTC-SSSAGSSSGYSSG 1110
            |..:..:.||:         |:..|.::..:  .:|.:| ||....:|.||:|
Zfish   658 SCLMSGSPLLH---------SSPVTPRWPDV--PSANSCYSSPTVHASRYSTG 699

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9727	NP_001262317.1	PHA03247	<40..207	CDD:223021
		RFX_DNA_binding	307..385	CDD:460512	29/74 (39%)
rfx4	NP_991275.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	25..59
		RFX_DNA_binding	58..136	CDD:460512	30/94 (32%)
		Necessary for dimerization	315..487		28/182 (15%)