Protein Alignment gpp and DOT1L

DIOPT Version :9

• Sequence 1: NP_731085.2
• Gene: gpp / 40793
• FlyBaseID: FBgn0264495
• Length: 2137
• Species: Drosophila melanogaster
• Sequence 2: XP_005259716.1
• Gene: DOT1L / 84444
• HGNCID: 24948
• Length: 1738
• Species: Homo sapiens
• Alignment Length: 2221
• Identity: 541/2221 - (24%)
• Similarity: 798/2221 - (35%)
• Gaps: 641/2221 - (28%)

  Fly     8 DLVLRSPAGSSDVISFAWPLQIGHGQDK-HDNGIDIIDTIKFVCDELPSMSSAFEETNLHQIDTA 71
            :|.|:||.|:...: :.|||.:   .|| ||...:||:||::||:|:|.:..|.|...|...||.
Human     6 ELRLKSPVGAEPAV-YPWPLPV---YDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVLIDYDTK 66

  Fly    72 CYKTMTGLVDRFNKAVDSIVALEKGTSLPAERLNKFAHPSLLRHILQLVYNAAVLDPDKLNQYEP 136
            .:::|..|.|::|:|:|||..|.|||:.|. :||......|||||||.|||.:|.||:|||.|||
Human    67 SFESMQRLCDKYNRAIDSIHQLWKGTTQPM-KLNTRPSTGLLRHILQQVYNHSVTDPEKLNNYEP 130

  Fly   137 FSPEVYGETSYELVQQMLKHVTVSKEDTFIDLGSGVGQVVLQMAGSFPLKTCIGIEKADTPARYA 201
            ||||||||||::||.||:..:.::.:|.|:||||||||||||:|.:...|...|:||||.||:||
Human   131 FSPEVYGETSFDLVAQMIDEIKMTDDDLFVDLGSGVGQVVLQVAAATNCKHHYGVEKADIPAKYA 195

  Fly   202 ERMDVIFRQYMGWFGKRFCEYKLIKGDFLVDEHRENITSSTLVFVNNFAFGPTVDHQLKERFADL 266
            |.||..||::|.|:||:..||.|.:||||.:|.||.|.:::::|||||||||.||||||||||::
Human   196 ETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFVNNFAFGPEVDHQLKERFANM 260

  Fly   267 RDGARVVSSKSFCPLNFRITDRNLSDIGTIMHVSEIPPLKGSVSWTCKPVSYYLHVIDRTILERY 331
            ::|.|:||||.|.||||||..||||||||||.|.|:.|||||||||.||||||||.|||||||.|
Human   261 KEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLKGSVSWTGKPVSYYLHTIDRTILENY 325

  Fly   332 FQRLKTKGGNDHESVGTVRTTRDRAKREANVGQHHHNNHHSNNHANSNNHQRDREQSNGATATAA 396
            |..||..         .:|..::.|:|                      .|:...:||.||.|
Human   326 FSSLKNP---------KLREEQEAARR----------------------RQQRESKSNAATPT-- 357

  Fly   397 HQQRHQSQSPANVSGAGIVLAASGQQAASKTRQQLQHQHNQQQRSLDMESSTESDGDATNGNGGN 461
                   :.|                                      |.......||...:|.
Human   358 -------KGP--------------------------------------EGKVAGPADAPMDSGA- 376

  Fly   462 TTTATNTTSASNGPMTRKVWSDWCSSKGKSSQSDDEENNNSNSNGGSNGGSIGGGSVGRQARATT 526
                                              :||                     :...||.
Human   377 ----------------------------------EEE---------------------KAGAATV 386

  Fly   527 QKKRKKLTRKAAIASKSAAAAQREAEAAAAAAVSVPSKESSSKEDPPRAASAGPGRKGRMKKGAR 591
            :|......||..:..|....|.|:                  :..|.:..:|.|.||.:..:.|
Human   387 KKPSPSKARKKKLNKKGRKMAGRK------------------RGRPKKMNTANPERKPKKNQTA- 432

  Fly   592 GRKSLKIVGLEALHKQTVLSTSLDTMTKKLPAAPGTVDQQLTALLTENMSHAELDIPTAPQDTPY 656
                     |:|||.|||..|:..: .:....:|.:...||...:..:..:..|..||.|
Human   433 ---------LDALHAQTVSQTAASS-PQDAYRSPHSPFYQLPPSVQRHSPNPLLVAPTPP----- 482

  Fly   657 ALQILLDVFRSQYTSMIEHMKSSAYVPQVQKQIAQEQERMARLKNRASQLDKQIKVLIDDSVALL 721
            |||.||:.|:.||...:.:.|:..|...:|:.:.||:|:.|:|...|.||....:...::...|.
Human   483 ALQKLLESFKIQYLQFLAYTKTPQYKASLQELLGQEKEKNAQLLGAAQQLLSHCQAQKEEIRRLF 547

  Fly   722 KVRMNELGIHVNSPNDLIAQAKEIVGRHKDLQHTASRMRNEVTFYEGEQKLLLNKQLKNLP---- 782
            :.:::|||:...:.||||...|||...::.|:..:.::..:.....|:...||..:.:.|.
Human   548 QQKLDELGVKALTYNDLIQAQKEISAHNQQLREQSEQLEQDNRALRGQSLQLLKARCEELQLDWA 612

  Fly   783 --EYQKLCGTVNGKVKLEVPPELSETTAQELVLKEIANTLSQRKKLYAQVSTIEQETSVLQ---- 841
              ..:||.     |.|..:..::||               .||..|..|:|.:|.|.|..|
Human   613 TLSLEKLL-----KEKQALKSQISE---------------KQRHCLELQISIVELEKSQRQQELL 657

  Fly   842 --KTAEERSTAATLLAQGTNMIVSTGSSSSSSTTVCASAVTAQSNKLNSVKNSRRNREHRARSQE 904
              |:......|.:|..:|...:.......:|...:...........|:|: :...:...:|...|
Human   658 QLKSCVPPDDALSLHLRGKGALGRELEPDASRLHLELDCTKFSLPHLSSM-SPELSMNGQAAGYE 721

  Fly   905 WPEVPEVGKIQESNPEVLAQKI---VETCRQIEAG-----KFQGAGAPSSQVNGKNKAIIE---- 957
            ...|......:::.|:.||..:   |..|.....|     |..|..||........|.::.
Human   722 LCGVLSRPSSKQNTPQYLASPLDQEVVPCTPSHVGRPRLEKLSGLAAPDYTRLSPAKIVLRRHLS 786

  Fly   958 ----VPPPPATAPVSIKSSPGHHYKDTTLMPAPKQQQQQQMTLS-QLPK------CELPGLSTSR 1011
                ||..||.:.:   .|...|.|:..| |.........|.|| |.|:      .:|.|..:|.
Human   787 QDHTVPGRPAASEL---HSRAEHTKENGL-PYQSPSVPGSMKLSPQDPRPLSPGALQLAGEKSSE 847

  Fly  1012 KQESPKVANFEDRLKSIITTALNEDQEQRSKAVESSPSPSPLHSPAPKRSKQHPAGAINPAQSLP 1076
            |....:.......|.:.:..::.....|.:|...|.|..|.:.....:|::..|:..:.| :...
Human   848 KGLRERAYGSSGELITSLPISIPLSTVQPNKLPVSIPLASVVLPSRAERARSTPSPVLQP-RDPS 911

  Fly  1077 NNLHNIITVSTQGLMHLNANTTISPITP---------PLPGPGAGATASTAP-PPPANLPYGAYG 1131
            :.|...|..:..|     |.:....:.|         .:.|..||:.||..| ..||.|...:..
Human   912 STLEKQIGANAHG-----AGSRSLALAPAGFSYAGSVAISGALAGSPASLTPGAEPATLDESSSS 971

  Fly  1132 GAVAKTTISGKYQAAKEPKYSPVRQAPLPPPPSHMASLYP------------AGQQTTPADLGYQ 1184
            |::. .|:..:....:.|......:..||..|:|..|..|            |.:...|:|.|:.
Human   972 GSLF-ATVGSRSSTPQHPLLLAQPRNSLPASPAHQLSSSPRLGGAAQGPLPEASKGDLPSDSGFS 1035

  Fly  1185 RRRSSVSATSYEHYMVQQQQQLQQQQLMLAAAAHAAQRQQMRVEEQQQQQQHQHHHHHHHHHPQH 1249
            ...|..                 :::::......|...:|....:               |.|..
Human  1036 DPESEA-----------------KRRIVFTITTGAGSAKQSPSSK---------------HSPLT 1068

  Fly  1250 R------LPQHVQHQHPHQHHPNEFKAPPADSHLQRSSSREQL-----IVEPPQTQPLELLPRAS 1303
            .      :|.|.|...............|:.| ...|..|..|     :...|...||.|....|
Human  1069 ASARGDCVPSHGQDSRRRGRRKRASAGTPSLS-AGVSPKRRALPSVAGLFTQPSGSPLNLNSMVS 1132

  Fly  1304 SANSDYSGYRIRPPSRPSSNSSQPDYTQVSPAKMALRRHLSQEKLSQHVTPQATPPLPGHGGAPT 1368
            :.|.......|..|.....:|..|......|..:...|.|||.. ..|.:|..:...||....|:
Human  1133 NINQPLEITAISSPETSLKSSPVPYQDHDQPPVLKKERPLSQTN-GAHYSPLTSDEEPGSEDEPS 1196

  Fly  1369 SGKTIGDLVNGEIERTLEISHQSIINAAVNMSTSGASFMERAFLNERSNDRLLINLNAQRPERVH 1433
            |.:         |||                                                 .
Human  1197 SAR---------IER-------------------------------------------------K 1203

  Fly  1434 VRPLSEESQDPQPTSYAQERGPGLGAGGAAAGG--------NSNLATLAHVAYAQKAQGGARANA 1490
            :..:|.||:.|..|   .|.|.||.....|..|        .|..:.::.:..|:.|....:|::
Human  1204 IATISLESKSPPKT---LENGGGLAGRKPAPAGEPVNSSKWKSTFSPISDIGLAKSADSPLQASS 1265

  Fly  1491 G-------TAPPATHSSSARSGRDYQPVALPRAELKGSIEAYFHEEQQQKQSKGAG--SAGSSSL 1546
            .       |..||....||    |.:..|.||....||:             .||.  |.|::..
Human  1266 ALSQNSLFTFRPALEEPSA----DAKLAAHPRKGFPGSL-------------SGADGLSPGTNPA 1313

  Fly  1547 RGPRLNGANPPLEGLAASLQDHVRARKYKEETEERQRRAAAAASSSAGPPAGMELPTHYAHQAPP 1611
            .|....|      ||||.|.
Human  1314 NGCTFGG------GLAADLS--------------------------------------------- 1327

  Fly  1612 AHSYHHHGASINGTPHKVELGIKRSSPLA-PHQQPPRPSKLAHYEPPTTQQQHAHAHLYANGQVL 1675
            .||: ..|||:   |||.......||||: |.|:....|
Human  1328 LHSF-SDGASL---PHKGPEAAGLSSPLSFPSQRGKEGS-------------------------- 1362

  Fly  1676 PPPPAHDATTPSPTPSSSSSSCGRRSNSNNGKLLVDPPL-LMSPEINSLLGDERPLQLSHHQQQQ 1739
                  || .|..:........|.:...:.||...:..| |..|.      |:.|| ||....:
Human  1363 ------DA-NPFLSKRQLDGLAGLKGEGSRGKEAGEGGLPLCGPT------DKTPL-LSGKAAK- 1412

  Fly  1740 QQMLHHHQSQQQQHLQLTQQQLRVAHLGHGLSHGHSTMPTLGGQRNGNG--NAADDDDVIAADDE 1802
                     .:.:.:.|..        ||.|....:.:|. |...:|.|  .||......|:..:
Human  1413 ---------ARDREVDLKN--------GHNLFISAAAVPP-GSLLSGPGLAPAASSAGGAASSAQ 1459

  Fly  1803 THWQHRVSSGFDRLVAFASTELDKTRRSIDGDTVPASISCNTSPDSGITHSSS------NSDAVR 1861
            ||.............|.....|.....|:.|.:|..|:..:....:|:.|.||      ||.|:.
Human  1460 THRSFLGPFPPGPQFALGPMSLQANLGSVAGSSVLQSLFSSVPAAAGLVHVSSAATRLTNSHAMG 1524

  Fly  1862 TFLSTSSSSSQLELPIGSGGSSCNSLYNH-------HAQHNNIGIGGSGGSHPHQQQQQLQAQHQ 1919
            :|             .|..|.:...::||       |.....:|.|.:.||..
Human  1525 SF-------------SGVAGGTVGGVFNHAVPSASAHPFGARVGRGAACGSAT------------ 1564

  Fly  1920 QQQHHLSDHMSDSSMKSSAS---SSLHAGSSLKT--------------------VSPVDPSAIES 1961
                     :..|.::::||   ||..|.:|::|                    .||..|..:.:
Human  1565 ---------LGPSPLQAAASASASSFQAPASVETRPPPPPPPPPPPLPPPAHLGRSPAGPPVLHA 1620

  Fly  1962 PPLSDVGLPRTPS------------------PSAASVATPPLASGPPVSGDLG----GIPLKYQR 2004
            ||..:..||..|:                  |:.|.:.....||.||.:..|.    .:|.|..|
Human  1621 PPPPNAALPPPPTLLASNPEPALLQSLASLPPNQAFLPPTSAASLPPANASLSIKLTSLPHKGAR 1685

  Fly  2005 KSKTSSEKHYKKKFCERNWEYDCDELLAYSNSSAPPTAADAAGNGP----LNLDAPNTVGGAPAP 2065
            .|.|   .|::             .|...:.:.|.|....|:..||    ::|       |.|.|
Human  1686 PSFT---VHHQ-------------PLPRLALAQAAPGIPQASATGPSAVWVSL-------GMPPP 1727

  Fly  2066 LLGK-SGKSPK 2075
            .... ||..|:
Human  1728 YAAHLSGVKPR 1738

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gpp	NP_731085.2	DOT1	121..323	CDD:149273	131/201 (65%)
DOT1L	XP_005259716.1	DOT1	115..317	CDD:149273	131/201 (65%)
		Rootletin	493..661	CDD:291694	44/187 (24%)
		Tropomyosin_1	508..660	CDD:289488	40/171 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142505
Domainoid	1	1.000	279	1.000	Domainoid score	I1707
eggNOG	1	0.900	-	-		E1_KOG3924
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	468	1.000	Inparanoid score	I1537
Isobase	1	0.950	-	0	Normalized mean entropy	S5493
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D55132at33208
OrthoFinder	1	1.000	-	-		FOG0003132
OrthoInspector	1	1.000	-	-		oto91751
orthoMCL	1	0.900	-	-		OOG6_103524
Panther	1	1.100	-	-	LDO	PTHR21451
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2094
SonicParanoid	1	1.000	-	-		X5335
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.740