DRSC/TRiP Functional Genomics Resources

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Protein Alignment gpp and dot1l

DIOPT Version :10

Sequence 1:NP_731085.2 Gene:gpp / 40793 FlyBaseID:FBgn0264495 Length:2137 Species:Drosophila melanogaster
Sequence 2:XP_073793894.1 Gene:dot1l / 559945 ZFINID:ZDB-GENE-060503-341 Length:1525 Species:Danio rerio


Alignment Length:1922 Identity:499/1922 - (25%)
Similarity:723/1922 - (37%) Gaps:642/1922 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 DLVLRSPAGSSDVISFAWPLQIGHGQDK-HDNGIDIIDTIKFVCDELPSMSSAFEETNLHQIDTA 71
            :|.|:||.| ::...:.|||.:   .|| ||...:||:||::||:|:|.:..|.|...|...||.
Zfish     6 ELKLKSPVG-AEAAGYPWPLPV---YDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVLIDYDTK 66

  Fly    72 CYKTMTGLVDRFNKAVDSIVALEKGTSLPAERLNKFAHPSLLRHILQLVYNAAVLDPDKLNQYEP 136
            .:::|..|.|::|:|:|||..|.|||:.|. :|||.....|||||||.|||.:|.||:|||.|||
Zfish    67 SFESMQRLCDKYNRAIDSIHQLWKGTTQPM-KLNKRPSNGLLRHILQQVYNHSVTDPEKLNNYEP 130

  Fly   137 FSPEVYGETSYELVQQMLKHVTVSKEDTFIDLGSGVGQVVLQMAGSFPLKTCIGIEKADTPARYA 201
            ||||||||||::||.|::..:.:.:||||:||||||||||||:|.:...|...|:||||.||.||
Zfish   131 FSPEVYGETSFDLVAQIIDEMEMMEEDTFVDLGSGVGQVVLQVAAATNCKHYYGVEKADIPATYA 195

  Fly   202 ERMDVIFRQYMGWFGKRFCEYKLIKGDFLVDEHRENITSSTLVFVNNFAFGPTVDHQLKERFADL 266
            |.||..|:::|.|:||:..||.|.:||||.:|.:|.|.|::::|||||||||.||||||||||::
Zfish   196 ESMDKEFKRWMKWYGKKHGEYTLERGDFLSEEWKERIASTSVIFVNNFAFGPEVDHQLKERFANM 260

  Fly   267 RDGARVVSSKSFCPLNFRITDRNLSDIGTIMHVSEIPPLKGSVSWTCKPVSYYLHVIDRTILERY 331
            ::|.::||||.|.||||||..||||||||||.|.|:.||:||||||.||||||||.|||||||.|
Zfish   261 KEGGKIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLRGSVSWTGKPVSYYLHTIDRTILENY 325

  Fly   332 FQRLKTKGGNDHESVGTVRTTRDRAKREANVGQHHHNNHHSNNHANSNNHQRDREQSNGATATAA 396
            |..||..         .:|..::.|:|..                     |:|.:::...|.|..
Zfish   326 FSSLKNP---------KLREEQEVARRRP---------------------QKDSKENKSNTTTPT 360

  Fly   397 HQQRHQSQSPANVSGAGIVLAASGQQAASKTRQQLQHQHNQQQRSLDMESSTESDGDATNGNGGN 461
            ..:.|:                             |.||:                     :||.
Zfish   361 KPKEHK-----------------------------QAQHD---------------------SGGE 375

  Fly   462 TTTATNTTSASNGPMTRKVWSDWCSSKGKSSQSDDEENNNSNSNGGSNGGSIGGGSVGRQARATT 526
            ..... ....|..|...|:.                          :.|..:|....||..:|  
Zfish   376 EEPVV-PVKPSPKPRRAKIL--------------------------TRGRKLGNRKRGRPKKA-- 411

  Fly   527 QKKRKKLTRKAAIASKSAAAAQREAEAAAAAAVSVPSKESSSKEDPPRAASAGPGRKGRMKKGAR 591
                           .:|.||:|:            :|:|.|                       
Zfish   412 ---------------PAATAAERK------------NKKSQS----------------------- 426

  Fly   592 GRKSLKIVGLEALHKQTVLSTSLDTMTKKLPAAPGTVDQQLTALLTENMSHAELDIPTAPQDTPY 656
                    .|:.||.:| ||.:......:.|.:|   ..||...:....|...|..||.|     
Zfish   427 --------ALDLLHAKT-LSAAPAQEPYRSPQSP---FYQLPPKVQHYTSSQLLMAPTPP----- 474

  Fly   657 ALQILLDVFRSQYTSMIEHMKSSAYVPQVQKQIAQEQERMARLKNRASQLDKQI---KVLIDDSV 718
            .||.|||..:.||...:.:||:..|...:|:.:.||:.|...|.::|.||....   |..|.|  
Zfish   475 GLQTLLDNIKVQYLHFMAYMKTPQYRTNLQQSLEQEKLRHTELSSQAQQLVNACHAHKERIHD-- 537

  Fly   719 ALLKVRMNELGIHVNSPNDLIAQAKEIVGRHKDLQHTASRMRNEVTFYEGEQKLLLNKQLKNLPE 783
             |.:.::.|||:...:..||:...|||...:..|:....::.:::.....:.:|||..:.:.| :
Zfish   538 -LFQSKLEELGVKAVTVEDLVQAQKEITAHNMQLREQTKQLEHDMAELRDQSQLLLKARCEEL-K 600

  Fly   784 YQKLCGTVNGKVKLEVPPELSETTAQELVLKEIANTLSQRKKLYAQVSTIEQETSVLQKTAEERS 848
            ...||...   :|.|:          |.:.::|:.  .||..|..|:|.:|.|.|..|:      
Zfish   601 LDTLCWDT---LKKEI----------EALRRQISE--KQRHCLELQISIVELEKSQRQQ------ 644

  Fly   849 TAATLLAQGTNMIVSTGSSSSSSTTVCASAVTAQSNKLNSVKNSRRNREHRARSQEWPEVPEVGK 913
               .||            ...||.:.|         :::..:.:....:.|....  |:.|::..
Zfish   645 ---ELL------------QLKSSYSPC---------EVSPYRKALPGPDPRPTLD--PDTPKLTP 683

  Fly   914 IQES------NPEVLAQKIVETCRQIEAGKFQGAGAP-----SSQVNGKNKAIIE---------- 957
             |.|      :||:               ...|..:|     :....|||:.:..          
Zfish   684 -QSSMGLNGLSPEL---------------SINGTASPGYERCTGSAMGKNELLTHYLPISPDHEI 732

  Fly   958 VPPPPAT--------APVSIKSSPG------HHYKDTTLMPAPKQQQQQQMTLSQLPKCELPGLS 1008
            |||.|.:        .|...:.||.      |..:|:.        ..|...|..:.:.:...:|
Zfish   733 VPPTPDSRTRQLGQPLPDYTRFSPAKIALRRHLNQDSA--------ANQFRALGNIHRGDTGAIS 789

  Fly  1009 TSR---KQESPKVANFEDRLKSIITTALNEDQEQRSKA-------VESSPSPSPLHSPAPKRSKQ 1063
            :..   ||.||..:..:     .:|||.|.|:..:.|:       :.|.|...||.:..|.:.  
Zfish   790 SPTLGFKQASPCSSEVQ-----AVTTAKNTDRADKEKSPTAPGDTITSLPISIPLSTVHPSKL-- 847

  Fly  1064 HPAGAINPAQSLPNNLHNIITVSTQGLMHLNANTTISPI---------TPPL-PGPGAGATAST- 1117
             |......:..|||.:..:             .:|.||:         .||| |..|.|.::|: 
Zfish   848 -PVSIPLASVVLPNRVERL-------------RSTPSPVLNPAGQSNGKPPLTPTSGTGYSSSSG 898

  Fly  1118 ------------------APPPPANLPYGAY----GGAVAKTTISGKYQAAKEPKYSPVRQAPLP 1160
                              |.|||.:.|....    .|........|..|.|..|       ..||
Zfish   899 LVNGSHSTMLTEDQDCDVASPPPHSTPVMGLQPRGSGLSPPLGTGGVLQYADGP-------PRLP 956

  Fly  1161 PPPSHMASLYPAGQQ--TTPADLGYQRRRSSVSATSYEHYMVQQQQQLQQQQLMLAAAAHAAQRQ 1223
            |...|...    |.:  |.|.| ...|||...|::|                   ::::.::...
Zfish   957 PEDGHERQ----GPESDTEPLD-SEARRRIFFSSSS-------------------SSSSSSSSTG 997

  Fly  1224 QMRVEEQQQQQQHQHHHHHHHHHPQHRLPQHVQHQHPHQHHPNEFKAPPADSHLQRSSSREQLIV 1288
            ..|:.....:|.|.||..|||||          |.|.|.|.|:        ||.|....|.:   
Zfish   998 GSRLHHGSVKQGHHHHSKHHHHH----------HHHHHHHSPS--------SHSQEGRKRGR--- 1041

  Fly  1289 EPPQTQPLELLPRASSANSDYSG---YRIRPPSRPSSNSS--------------QP-DYTQVSPA 1335
                      ..|:||.....||   .|:.|....||:||              || :.:.:|..
Zfish  1042 ----------RKRSSSGAVPMSGSPKRRVFPGLGCSSHSSGSPLNINSMVNNINQPLEISAISSP 1096

  Fly  1336 KMALRRHLSQEKLSQHVTPQATPPL----------------PGHGGAPTSGK---------TIGD 1375
            :.:.|....|: |.|....:...||                .|:|.||.:..         ||..
Zfish  1097 EQSGRSPCGQD-LDQPPVLKRERPLELNNTGRYSSAPSSDEEGNGYAPDTSSSSRIERKIATISL 1160

  Fly  1376 LVNG---EIERTLE--ISHQSIINAAVNMSTSGASFMERAFLNERSNDRLLINLNAQRPERVHVR 1435
            ..:|   ::||.|:  .|..|.:::.|: |:||.|..:..|                       .
Zfish  1161 DRDGPVRDLERGLQGRKSGASSVSSEVS-SSSGTSKWKSTF-----------------------S 1201

  Fly  1436 PLSEESQDPQPTSYAQERGPGLGAGGAAAGGNSNLATLAHVAYAQKAQGGARANAGTAPPATHSS 1500
            |:|    ||:||.      |.:..||:..                 :.|.:|  .||...:.|..
Zfish  1202 PIS----DPKPTP------PDIRQGGSPF-----------------SVGASR--GGTDSDSDHKP 1237

  Fly  1501 SARSGRDYQPVALPRAEL----KGSIEAYFHEEQQQKQS---------KGAGSAG---SSSLRGP 1549
            ..|..|:.:|.......|    .|.......|...|||.         .|..|..   |::..|.
Zfish  1238 QRRGEREREPYGNSNLFLSQDGSGRSAVNTSERSLQKQKVREWDLKSVSGLASQNLFISAAASGG 1302

  Fly  1550 RLNGANPPLEGLAASLQDHVRARKYKEETEERQRRAAAAASSSAGPPAGMELPTHYAHQAPPAHS 1614
            .|:|                              :...||:.|:....|...|...|....|...
Zfish  1303 ILSG------------------------------KVGGAATVSSASAVGQYFPLGGASVLQPLFG 1337

  Fly  1615 YHHHGASINGTPHKVE----LGIKRSSPLA---------------PHQQ--PPRPSKLAHYEPPT 1658
            ....|.:.:|.|..|.    ||...|:.||               ..||  |..||  :|    .
Zfish  1338 TQAAGPATSGAPRLVNGHSALGSFSSAGLAGGAAGGIFHHMVSSSSSQQSGPNLPS--SH----N 1396

  Fly  1659 TQQQH------AHAHLYANGQ---------------VLPPPPAHDATTPS--------------P 1688
            :||:|      |.|...|:|.               .|||||....|.||              |
Zfish  1397 SQQRHLDTNPKAGASFLASGPNRTQTVLHAPSPPTLALPPPPPLLNTVPSQPSSPRSSRPQSSIP 1461

  Fly  1689 TPSSS------SSSCGRRSNSNNGKLLVD-PPLLMSP 1718
            ..:||      ||||  .|::::....|. ||.|..|
Zfish  1462 VATSSQSLAAASSSC--TSSASSRPFTVHYPPHLQPP 1496

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
gppNP_731085.2 DOT1 121..323 CDD:149273 129/201 (64%)
CC_DOT1L 657..721 CDD:411016 21/66 (32%)
dot1lXP_073793894.1 None

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