DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gpp and Dot1l

DIOPT Version :9

Sequence 1:	NP_731085.2	Gene:	gpp / 40793	FlyBaseID:	FBgn0264495	Length:	2137	Species:	Drosophila melanogaster
Sequence 2:	XP_006241021.1	Gene:	Dot1l / 362831	RGDID:	1306644	Length:	1736	Species:	Rattus norvegicus

Alignment Length:	2242	Identity:	539/2242 - (24%)
Similarity:	806/2242 - (35%)	Gaps:	685/2242 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 DLVLRSPAGSSDVISFAWPLQIGHGQDK-HDNGIDIIDTIKFVCDELPSMSSAFEETNLHQIDTA 71
            :|.|:||.|:...: :.|||.:   .|| ||...:||:||::||:|:|.:..|.|...|...||.
  Rat     6 ELRLKSPVGAEPAV-YPWPLPV---YDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVLIDYDTK 66

  Fly    72 CYKTMTGLVDRFNKAVDSIVALEKGTSLPAERLNKFAHPSLLRHILQLVYNAAVLDPDKLNQYEP 136
            .:::|..|.|::|:|:|||..|.|||:.|. :||......|||||||.|||.:|.||:|||.|||
  Rat    67 SFESMQRLCDKYNRAIDSIHQLWKGTTQPM-KLNTRPSNGLLRHILQQVYNHSVTDPEKLNNYEP 130

  Fly   137 FSPEVYGETSYELVQQMLKHVTVSKEDTFIDLGSGVGQVVLQMAGSFPLKTCIGIEKADTPARYA 201
            ||||||||||::||.||:..:.::::|.|:||||||||||||:|.:...|...|:||||.||:||
  Rat   131 FSPEVYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVLQVAAATNCKHHYGVEKADIPAKYA 195

  Fly   202 ERMDVIFRQYMGWFGKRFCEYKLIKGDFLVDEHRENITSSTLVFVNNFAFGPTVDHQLKERFADL 266
            |.||..||::|.|:||:..||.|.:||||.:|.||.|.:::::|||||||||.||||||||||::
  Rat   196 ETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFVNNFAFGPEVDHQLKERFANM 260

  Fly   267 RDGARVVSSKSFCPLNFRITDRNLSDIGTIMHVSEIPPLKGSVSWTCKPVSYYLHVIDRTILERY 331
            ::|.|:||||.|.||||||..||||||||||.|.|:.|||||||||.||||||||.|||||||.|
  Rat   261 KEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLKGSVSWTGKPVSYYLHTIDRTILENY 325

  Fly   332 FQRLKTKGGNDHESVGTVRTTRDRAKREANVGQHHHNNHHSNNHANSNNHQRDREQSNGATATAA 396
            |..||                                            :.:.||
  Rat   326 FSSLK--------------------------------------------NPKLRE---------- 336

  Fly   397 HQQRHQSQSPANVSGAGIVLAASGQQAASKTRQQLQHQHNQQQRSLDMESSTESDGDATNGNGGN 461
                                    :|.|::.|||.:                         |..|
  Rat   337 ------------------------EQEAARRRQQRE-------------------------NKSN 352

  Fly   462 TTTATNTTSASNGPMTRKVWSDWCSSKGKSSQSDDEENNNSNSNGGSNGGSIGGGSVGRQARATT 526
            .||.|
  Rat   353 ATTPT------------------------------------------------------------ 357

  Fly   527 QKKRKKLTRKAAIASKSAAAAQREAEAAAAAAVSVPSKESSSKEDPPRAASAGPGRKGRMKKGAR 591
                 |:....|.|:::.|.:..|.|.:..|.|        .|:.|.:|......:|||...|.:
  Rat   358 -----KVPESKAAATEAPADSGAEEEKSGVATV--------KKQSPSKARKKKLNKKGRKMAGRK 409

  Fly   592 GRKSLKIVGLEALHKQTVLSTSLDTMTKKLPAAPGTVDQQ--------LTALLTENMSHAELDIP 648
            ..:..|:....|..|.....::||.:....||.|....|.        ...|......|:...:.
  Rat   410 RGRPKKMSAASADRKSKKSQSTLDLLHSPPPAPPSASPQDAYRAPHSPFYQLPPSTPLHSPDPLL 474

  Fly   649 TAPQDTPYALQILLDVFRSQYTSMIEHMKSSAYVPQVQKQIAQEQERMARLKNRASQLDKQIKVL 713
            .||  ||.|||.||:.|:.||...:.:.|:..|...:|:.:.||:|:..:|...|.||....:..
  Rat   475 VAP--TPPALQKLLESFKIQYLQFLAYTKTPQYKANLQQLLDQEKEKNTQLLGTAQQLFSHCQAQ 537

  Fly   714 IDDSVALLKVRMNELGIHVNSPNDLIAQAKEIVGRHKDLQHTASRMRNEVTFYEGEQKLLLNKQL 778
            .::...|.:.:::|||:...:.||||...|||...::.|:..:.::..:.:....:...||..:.
  Rat   538 KEEIRRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQSEQLEKDNSELRSQSLRLLRARC 602

  Fly   779 KNLP-EYQKLCGTVNGKVKLEVPPELSETTAQELVLKEIANTLSQRKKLYAQVSTIEQETSVLQ- 841
            :.|. ::..|......|.|..:..::||               .||..|..|:|.:|.|.:..|
  Rat   603 EELRLDWSTLSLENLRKEKQALRSQISE---------------KQRHCLELQISIVELEKTQRQQ 652

  Fly   842 -----KTAEERSTAATLLAQGTNMIVSTGSSSSSSTTVCASAVTAQSNKLNSVKNSRRNREHRAR 901
                 |:......|.:|..:|...:.....|.:....:...........|:|:........| |.
  Rat   653 ELLQLKSCVPPDDALSLHLRGKGALGRELESDAGRLRLELDCAKLSLPHLSSMSPELSMNGH-AA 716

  Fly   902 SQEWPEVPEVGKIQESNPEVLAQKI---VETCRQIEAG-----KFQGAGAP-------------- 944
            |.|..........:::.|:.||..:   |..|....:|     |..|...|
  Rat   717 SYELCGAASRPSSKQNTPQYLASPLDQEVVPCTPSHSGRPRLEKLSGLALPDYTRLSPAKIVLRR 781

  Fly   945 --SSQVNGKNKAIIEVPPPPATAPVSIKSSPGHHYKDTTLMPAPKQQQQQQMTLSQLPKCELPGL 1007
              |....|.:||....|.|..           .|.|:.:|   |.|.               |||
  Rat   782 HLSQDHTGASKAATSEPHPRP-----------EHAKENSL---PYQS---------------PGL 817

  Fly  1008 STSRK---QESPKVANFEDRLKSIITTALNEDQ-----------EQRSKAVESSPSPSPLHSPAP 1058
            |.|.|   |:.|        |.|..|:.|..::           ....:.:.|.|...||.:..|
  Rat   818 SNSMKLSPQDPP--------LASPATSPLTSERGSEKGVKERAYSSHGETITSLPVSIPLSTVQP 874

  Fly  1059 ------------------KRSKQHPAGAINPAQSLPNNLHNIITVSTQGLMHLNANTTISPITPP 1105
                              :|::..|:....|..| .:.|...|..||.|
  Rat   875 NKLPVSIPLASVVLPSRAERARSTPSPVPQPRDS-SSTLEKQIGASTHG---------------- 922

  Fly  1106 LPGPGAGATASTAPPPPANLPYGAYGGAVAKTTISGKYQAAKEPKYSPVRQAPLPPPPSHMASLY 1170
            ..|..||:.:.|..|.      |.|.|:||   |||...::..|..|.:..|.........:...
  Rat   923 AGGAAAGSRSLTVAPT------GFYAGSVA---ISGALASSPAPLASGMESAVFEESSGPSSLFG 978

  Fly  1171 PAGQQTTPAD---LGYQRRRSSVSATSYEHYMVQQQQQLQQQQLMLAAAAHAAQRQQMRVEEQQQ 1232
            ..|.::||..   |..|.|.|..::.:::                |||:...:...|..:.:..:
  Rat   979 TMGSRSTPPQHPPLLPQSRNSGPASPAHQ----------------LAASPRLSVTTQGSLPDTGK 1027

  Fly  1233 QQQHQHHHHHHHHHPQHRLPQHVQHQHPHQHHPNEFKAPPADSHLQRSSSREQLIVEPPQTQ--P 1295
            .:                ||.......|.    :|.|.....|....:|||:.     |.|:  |
  Rat  1028 GE----------------LPADPAFSDPE----SEAKRRIVFSISAGASSRQS-----PSTRHSP 1067

  Fly  1296 LELLPRASSANSDYSGYRIRPPSRPSSNSSQPDYTQVSPAKMALRRHLSQEKLSQHVTPQATPPL 1360
            |....|.....|.....|.|...:.:|..:....|.|||.:.||                  |.:
  Rat  1068 LTSGTRGDCVQSHGQDSRKRSRRKRASAGTPSLTTGVSPKRRAL------------------PTV 1114

  Fly  1361 PG----HGGAPTSGKTIGDLVNGEIERTLEISHQSIINAAVNMSTSGASFMERAFLNERSNDRLL 1421
            .|    ..|:|.:..::...:|..:|.|...|.:|      ::.:|...:.:        :|:..
  Rat  1115 AGLFTQSSGSPLNLTSMVSNINQPLEITAISSPES------SLKSSPTPYQD--------HDQPP 1165

  Fly  1422 INLNAQRP----ERVHVRPLS---EESQDPQPTSYAQERGPGLGAGGAAAGGNSNLATLAHVAYA 1479
            : |..:||    ...|..||:   |...:.:|:|...||                  .:|.::..
  Rat  1166 V-LRKERPLGPTNGAHYSPLTSDEEPGSEDEPSSARIER------------------KIATISLE 1211

  Fly  1480 QKA------QGGARANAGTAPPATHSSSARSGRDYQPVA---LPRAELKGSIEAYFHEEQQQKQS 1535
            .|:      .||........|.....:|::....:.|::   |.:| :...::|
  Rat  1212 SKSPPKTLENGGGLVGRKPVPSGEPVNSSKWKSTFSPISDLGLAKA-MDSPLQA----------- 1264

  Fly  1536 KGAGSAGSSSLRGPRLNGANPPLEGLAASLQDHVRARKYKEETEERQRRAAAAASSSAGPPAGME 1600
                   ||:|....|....|.||..||..:.....||          ..|.:.:::.||..|..
  Rat  1265 -------SSALSHSPLFSFRPSLEEPAAEAKPSTHPRK----------SFAGSLAAAEGPSPGTN 1312

  Fly  1601 LPTHYAHQAPPA-----HSYH------HHGASINGTPHKVELGIKR-------SSPLAPHQQPPR 1647
            .|...|.....|     ||::      |.|..:.|....:....:|       ::|....:||..
  Rat  1313 PPNSLAFSGGLAADLGLHSFNDGASLSHKGPEVAGLSASLSFPSQRGKDSTTEANPFLSRRQPEG 1377

  Fly  1648 PSKLAHYEPPTTQQQHAHAHLYANGQVLPPPPAHDATTPSPTPSSSSSSCGRRSNSNNGKLLVDP 1712
            ...|.. |...:::         :|:.||.....|..:   .|..|.:|.||
  Rat  1378 LGGLKG-EGNASKE---------SGESLPLCGPSDKVS---LPHGSRASKGR------------- 1416

  Fly  1713 PLLMSPEINSLLGDERPLQLSHHQQQQQQMLHHHQSQQQQHLQLTQQQLRVAHLGHGLSHGHSTM 1777
                          :|.|....                                ||.|....:.:
  Rat  1417 --------------DRELDFKG--------------------------------GHNLFISAAAV 1435

  Fly  1778 PTLGGQRNGNGNAADDDDVIAADDETHWQHRVSSGFDRLVAF--ASTELDKTRRSIDGDTVPASI 1840
            |. ||...|.|.........:|...........|.|.....|  ....|.....|:.|.:|..|:
  Rat  1436 PP-GGLLGGPGLVTVASSAGSATPSAQAPRPFLSTFAPGPQFTLGPMSLQANLGSVAGSSVLQSL 1499

  Fly  1841 SCNTSPDSGITHSSSNSDAVRTFLSTSSSSSQLELPIGSGGSSCNSLYNH---HAQHNNIGIG-G 1901
            .......:|:.|.||.:..:....:..|.||      |..|.:...::.|   .|..:..|.| |
  Rat  1500 FSTVPAAAGLVHVSSTATRLTNSHTMGSFSS------GVAGGTVGGVFTHAVPSASAHPFGAGVG 1558

  Fly  1902 SG--------GSHPHQQQQQLQAQHQQQQHHLSDHMSDSSMKSSASSSLHAGSSLKT-------- 1950
            ||        |..|      |||                 ..|:::||..|.:|::|
  Rat  1559 SGAVCSSATLGLSP------LQA-----------------AASTSASSFQAAASVETRPPPPPPL 1600

  Fly  1951 -------VSPVDPSAIESPPLSDVGLPRTPS-------------------------PSAASVATP 1983
                   ..|..|..:.:||..:|.||..|:                         ||:||...|
  Rat  1601 LPPQHLGRPPAGPPVLHAPPPPNVALPPPPALLASNPEPVLLQSLASLPANNAFLPPSSASSLQP 1665

  Fly  1984 PLASGPPVSGDLGGIPLKYQRKSKTSSEKHYKKKFCERNWEYDCDELLAYSNSSAPPTAADAAGN 2048
            ..||   :|..|..:|.|..|.|.|   .|::             .|...:.:.|.|.|..|:.:
  Rat  1666 ANAS---LSVKLASLPHKVSRPSFT---VHHQ-------------PLPRLALAQAAPAAPQASTS 1711

  Fly  2049 GP----LNLDAPNTVGGAPAPLLGK-SGKSPK 2075
            ||    ::|       |.|.|.... ||..|:
  Rat  1712 GPSAVWVSL-------GMPPPYAAHLSGVKPR 1736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gpp	NP_731085.2	DOT1	121..323	CDD:149273	131/201 (65%)
Dot1l	XP_006241021.1	DOT1	115..317	CDD:149273	131/201 (65%)
		Rootletin	491..659	CDD:291694	40/182 (22%)
		PKK	535..652	CDD:289257	27/131 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336012
Domainoid	1	1.000	280	1.000	Domainoid score	I1613
eggNOG	1	0.900	-	-		E1_KOG3924
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	460	1.000	Inparanoid score	I1510
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D55132at33208
OrthoFinder	1	1.000	-	-		FOG0003132
OrthoInspector	1	1.000	-	-		oto98816
orthoMCL	1	0.900	-	-		OOG6_103524
Panther	1	1.100	-	-	LDO	PTHR21451
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5335
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.890