DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gpp and Dot1l

DIOPT Version :9

Sequence 1:	NP_731085.2	Gene:	gpp / 40793	FlyBaseID:	FBgn0264495	Length:	2137	Species:	Drosophila melanogaster
Sequence 2:	XP_006513492.1	Gene:	Dot1l / 208266	MGIID:	2143886	Length:	1736	Species:	Mus musculus

Alignment Length:	2261	Identity:	553/2261 - (24%)
Similarity:	825/2261 - (36%)	Gaps:	723/2261 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 DLVLRSPAGSSDVISFAWPLQIGHGQDK-HDNGIDIIDTIKFVCDELPSMSSAFEETNLHQIDTA 71
            :|.|:||.|:...: :.|||.:   .|| ||...:||:||::||:|:|.:..|.|...|...||.
Mouse     6 ELRLKSPVGAEPAV-YPWPLPV---YDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVLIDYDTK 66

  Fly    72 CYKTMTGLVDRFNKAVDSIVALEKGTSLPAERLNKFAHPSLLRHILQLVYNAAVLDPDKLNQYEP 136
            .:::|..|.|::|:|:|||..|.|||:.|. :||......|||||||.|||.:|.||:|||.|||
Mouse    67 SFESMQRLCDKYNRAIDSIHQLWKGTTQPM-KLNTRPSNGLLRHILQQVYNHSVTDPEKLNNYEP 130

  Fly   137 FSPEVYGETSYELVQQMLKHVTVSKEDTFIDLGSGVGQVVLQMAGSFPLKTCIGIEKADTPARYA 201
            ||||||||||::||.||:..:.::::|.|:||||||||||||:|.:...|...|:||||.||:||
Mouse   131 FSPEVYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVLQVAAATNCKHHYGVEKADIPAKYA 195

  Fly   202 ERMDVIFRQYMGWFGKRFCEYKLIKGDFLVDEHRENITSSTLVFVNNFAFGPTVDHQLKERFADL 266
            |.||..||::|.|:||:..||.|.:||||.:|.||.|.:::::|||||||||.||||||||||::
Mouse   196 ETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFVNNFAFGPEVDHQLKERFANM 260

  Fly   267 RDGARVVSSKSFCPLNFRITDRNLSDIGTIMHVSEIPPLKGSVSWTCKPVSYYLHVIDRTILERY 331
            ::|.|:||||.|.||||||..||||||||||.|.|:.|||||||||.||||||||.|||||||.|
Mouse   261 KEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLKGSVSWTGKPVSYYLHTIDRTILENY 325

  Fly   332 FQRLKTKGGNDHESVGTVRTTRDRAKREANVGQHHHNNHHSNNHANSNNHQRDREQSNGATATAA 396
            |..||                                            :.:.||
Mouse   326 FSSLK--------------------------------------------NPKLRE---------- 336

  Fly   397 HQQRHQSQSPANVSGAGIVLAASGQQAASKTRQQLQHQHNQQQRSLDMESSTESDGDATNGNGGN 461
                                    :|.|::.|||.:                         |..|
Mouse   337 ------------------------EQEAARRRQQRE-------------------------NKSN 352

  Fly   462 TTTATNTTSASNGPMTRKVWSDWCSSKGKSSQSDDEENNNSNSNGGSNGGSIGGGSVGRQARATT 526
            .||.|
Mouse   353 ATTPT------------------------------------------------------------ 357

  Fly   527 QKKRKKLTRKAAIASKSAAAAQREAEAAAAAAVSVPSKESSSKEDPPRAASAGPGRKGRMKKGAR 591
                 |:....|.|:::.|.:..|.|.:..|.|..||        |.:|......:|||...|.:
Mouse   358 -----KVPESKAAATEAPADSGAEEEKSGVATVKKPS--------PSKARKKKLNKKGRKMAGRK 409

  Fly   592 GRKSLKIVGLEALHKQTVLSTSLDTMTKKLPAAPGTVDQQ--------LTALLTENMSHAELDIP 648
            ..:..|:....|..|.....::||.:....||.|....|.        ...|......|:...:.
Mouse   410 RGRPKKMSAASAERKSKKSQSTLDLLHSPPPAPPSASPQDAYRAPHSPFYQLPPSTQLHSPNPLL 474

  Fly   649 TAPQDTPYALQILLDVFRSQYTSMIEHMKSSAYVPQVQKQIAQEQERMARLKNRASQLDKQIKVL 713
            .||  ||.|||.||:.||.||...:.:.|:..|...:|:.:.||:|:..:|...|.||....:..
Mouse   475 VAP--TPPALQKLLESFRIQYLQFLAYTKTPQYKANLQQLLDQEKEKNTQLLGTAQQLFGHCQAQ 537

  Fly   714 IDDSVALLKVRMNELGIHVNSPNDLIAQAKEIVGRHKDLQHTASRMRNEVTFYEGEQKLLLNKQL 778
            .::...|.:.:::|||:...:.||||...|||...::.|:..:.::..:.:....:...||..:.
Mouse   538 KEEIRRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQSEQLEKDNSELRSQSLRLLRARC 602

  Fly   779 KNLP-EYQKLCGTVNGKVKLEVPPELSETTAQELVLKEIANTLSQRKKLYAQVSTIEQETSVLQ- 841
            :.|. ::..|......|.|..:..::||               .||..|..|:|.:|.|.:..|
Mouse   603 EELRLDWSTLSLENLRKEKQALRSQISE---------------KQRHCLELQISIVELEKTQRQQ 652

  Fly   842 -----KTAEERSTAATLLAQGTNMIVSTGSSSSSSTTVCASAVTAQSNKLNSVKNSRRNREHRAR 901
                 |:......|.:|..:|...:.....:.:....:...........|:|:........| |.
Mouse   653 ELLQLKSCVPPDDALSLHLRGKGALGRELEADAGRLRLELDCAKISLPHLSSMSPELSMNGH-AA 716

  Fly   902 SQEWPEVPEVGKIQESNPEVLAQKI---VETCRQIEAG-----KFQGAGAP-------------- 944
            |.|..........:::.|:.||..:   |..|....:|     |..|...|
Mouse   717 SYELCNAASRPSSKQNTPQYLASPLDQEVVPCTPSHSGRPRLEKLSGLALPDYTRLSPAKIVLRR 781

  Fly   945 --SSQVNGKNKAIIEVPPPPATAPVSIKSSPGHHYKDTTLMPAPKQQQQQQMTLSQLPKCELPGL 1007
              |....|.:||....|.|          .|.|          ||:        |.|| .:.|||
Mouse   782 HLSQDHTGASKAATSEPHP----------RPEH----------PKE--------SSLP-YQSPGL 817

  Fly  1008 STSRK---QESPKVANFEDRLKSIITTALNEDQ-----------EQRSKAVESSPSPSPLHSPAP 1058
            |.|.|   |:.|        |.|..|:.|..::           ....:.:.|.|...||.:..|
Mouse   818 SNSMKLSPQDPP--------LASPATSPLTSEKGSEKGVKERAYSSHGETITSLPVSIPLSTVQP 874

  Fly  1059 KRSKQHPAGAINPAQSLPNNLHNIITVSTQGLMHLNANTTISPITPP-----------------L 1106
            .:.         |. |:|  |.:::..|...    .|.:|.||:..|                 .
Mouse   875 NKL---------PV-SIP--LASVVLPSRAE----RARSTPSPVPQPRDSSATLEKQTGASAHGA 923

  Fly  1107 PGPGAGATASTAPPPPANLPYGAYGGAVAKTTISGKYQAAKEPKYSPVRQAPLPP---PPSHMAS 1168
            .|.|||:.:.      |..|.|.|.|:||   |||...::..|..|.:..|....   |.|..|:
Mouse   924 GGAGAGSRSL------AVAPTGFYAGSVA---ISGALASSPAPLASGMESAVFDESSGPSSLFAT 979

  Fly  1169 LYPAGQQTTPAD---LGYQRRRSSVSATSYEHYMVQQQQQLQQQQLMLAAAAHAAQRQQMRVEEQ 1230
            :   |.::||..   |..|.|.|..::.:::                |.|:...:...|..:.:.
Mouse   980 M---GSRSTPPQHPPLLSQSRNSGPASPAHQ----------------LTASPRLSVTTQGSLPDT 1025

  Fly  1231 QQQQQHQHHHHHHHHHPQHRLPQHVQHQHPHQHHPNEFKAPPADSHLQRSSSREQLIVEPPQTQ- 1294
            .:.:                ||.......|.    :|.|.....|....:||::.     |.|:
Mouse  1026 SKGE----------------LPSDPAFSDPE----SEAKRRIVFSISVGASSKQS-----PSTRH 1065

  Fly  1295 -PLELLPRASSANSDYSGYRIRPPSRPSSNSSQPDYTQVSPAKMALRRHLSQEKLSQHVTPQATP 1358
             ||....|.....|.....|.|...:.:|..:....|.|||.:.||                  |
Mouse  1066 SPLTSGTRGDCVQSHGQDSRKRSRRKRASAGTPSLSTGVSPKRRAL------------------P 1112

  Fly  1359 PLPG----HGGAPTSGKTIGDLVNGEIERTLEISHQSIINAAVNMSTSGASFMERAFLNERSNDR 1419
            .:.|    ..|:|.:..::...:|..:|.|...|.:|      ::.:|...:.:        :|:
Mouse  1113 TVAGLFTQSSGSPLNLNSMVSNINQPLEITAISSPES------SLKSSPTPYQD--------HDQ 1163

  Fly  1420 LLINLNAQRP----ERVHVRPLS---EESQDPQPTSYAQERGPGLGAGGAAAGGNSNLATLAHVA 1477
            ..: |..:||    ...|..||:   |...:.:|:|...||                  .:|.::
Mouse  1164 PPV-LRKERPLGLTNGAHYSPLTSDEEPGSEDEPSSARIER------------------KIATIS 1209

  Fly  1478 YAQKA------QGGARANAGTAPPATHSSSARSGRDYQPVALPRAELKGSIEAYFHEEQQQKQSK 1536
            ...|:      .||......:||.:...:|::....:.|:    ::| |..:|.....|
Mouse  1210 LESKSPPKTLENGGGLVGRKSAPSSEPINSSKWKSTFSPI----SDL-GLAKAVDSPLQ------ 1263

  Fly  1537 GAGSAGSSSLRGPRLNGANPPLEGLAASLQDHVRARKYKEETEERQRRAAAAASSSAGPPAGMEL 1601
             ||||.|.|           ||.....||::  .|.:.|..|..| :..|.:..::.||..|...
Mouse  1264 -AGSALSHS-----------PLFSFRPSLEE--PAAEAKLPTHPR-KSFAGSLGAAEGPSPGTNP 1313

  Fly  1602 PTHYAHQAPPA-----HSYH------HHGASINGTPHKVELGIKR-------SSPLAPHQQPPRP 1648
            |...|.....|     ||::      |.|..:.|....:....:|       ::|....:||...
Mouse  1314 PNGLAFSGGLAADLGLHSFNDGASLSHKGPDVTGLSASLSFPSQRGKDSTTEANPFLSRRQPEGL 1378

  Fly  1649 SKL-----AHYEPPTTQQQHAHAHLYANGQVLPPPPAHDATTPSPTPSSSSSSCGRRSNSNNGKL 1708
            ..|     |:.|               :|:.||.....|..:   .|..|.:|.||
Mouse  1379 GGLKGEGNANKE---------------SGESLPLCGPSDKAS---LPHGSRASKGR--------- 1416

  Fly  1709 LVDPPLLMSPEINSLLGDERPLQLSHHQQQQQQMLHHHQSQQQQHLQLTQQQLRVAHLGHGLSHG 1773
                              :|.|....                                ||.|...
Mouse  1417 ------------------DRELDFKG--------------------------------GHNLFIS 1431

  Fly  1774 HSTMPTLGGQRNGNGNAADDDDVIAADDETHWQHRVSSGFDRLVA-----FAST----------- 1822
            .:.:|. ||...|.|..     .:|:          |:|.....|     |.||
Mouse  1432 AAAVPP-GGLLGGPGLV-----TVAS----------SAGSATPTAQAPRPFLSTFAPGPQFTLGP 1480

  Fly  1823 -ELDKTRRSIDGDTVPASISCNTSPDSGITHSSSNSDAVRTFLSTSSSSSQLELPIGSGGSSCNS 1886
             .|.....|:.|.:|..|:.......:|:.|.||.:..:....:..|.||      |..|.:...
Mouse  1481 MSLQANLGSVAGSSVLQSLFSTVPAAAGLVHVSSTATRLTNSHTMGSFSS------GVAGGTVGG 1539

  Fly  1887 LYNH---HAQHNNIGIG-GSG--------GSHPHQQQQQLQAQHQQQQHHLSDHMSDSSMKSSAS 1939
            ::.|   .|..:..|.| |||        |..|      |||                 ..|:::
Mouse  1540 VFTHAVPSASAHPFGAGVGSGAVCSSATLGLSP------LQA-----------------AASTSA 1581

  Fly  1940 SSLHAGSSLKT---------------VSPVDPSAIESPPLSDVGLPRTPS--------------- 1974
            ||..|.:|::|               ..|..|..:.:||..:|.||..|:
Mouse  1582 SSFQAAASVETRPPPPPPLLPPQHLGRPPAGPPVLHAPPPPNVALPPPPALLASNPEPVLLQSLA 1646

  Fly  1975 ----------PSAASVATPPLASGPPVSGDLGGIPLKYQRKSKTSSEKHYKKKFCERNWEYDCDE 2029
                      ||:|:...|..||   :|..|..:|.|..|.|.|   .|::             .
Mouse  1647 SLPANNAFLPPSSAASLQPANAS---LSVKLASLPHKVSRPSFT---VHHQ-------------P 1692

  Fly  2030 LLAYSNSSAPPTAADAAGNGP----LNLDAPNTVGGAPAPLLGK-SGKSPK 2075
            |...:.:.|.|.|..|:.:||    ::|       |.|.|.... ||..|:
Mouse  1693 LPRLALAQAAPAAPQASTSGPSAVWVSL-------GMPPPYAAHLSGVKPR 1736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gpp	NP_731085.2	DOT1	121..323	CDD:149273	131/201 (65%)
Dot1l	XP_006513492.1	DOT1	115..317	CDD:149273	131/201 (65%)
		Mplasa_alph_rch	<510..>659	CDD:275316	36/163 (22%)
		PHA03307	781..>1125	CDD:223039	96/467 (21%)
		Herpes_BLLF1	<942..1314	CDD:282904	97/495 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832355
Domainoid	1	1.000	280	1.000	Domainoid score	I1676
eggNOG	1	0.900	-	-		E1_KOG3924
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	461	1.000	Inparanoid score	I1547
Isobase	1	0.950	-	0	Normalized mean entropy	S5493
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003132
OrthoInspector	1	1.000	-	-		oto95331
orthoMCL	1	0.900	-	-		OOG6_103524
Panther	1	1.100	-	-	LDO	PTHR21451
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2094
SonicParanoid	1	1.000	-	-		X5335
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.820