Protein Alignment gpp and dot-1.1

DIOPT Version :10

• Sequence 1: NP_731085.2
• Gene: gpp / 40793
• FlyBaseID: FBgn0264495
• Length: 2137
• Species: Drosophila melanogaster
• Sequence 2: NP_740808.2
• Gene: dot-1.1 / 171797
• WormBaseID: WBGene00021474
• Length: 946
• Species: Caenorhabditis elegans
• Alignment Length: 825
• Identity: 196/825 - (23%)
• Similarity: 322/825 - (39%)
• Gaps: 185/825 - (22%)

  Fly    42 IIDTIKFVCDELPSMSSAFEETNLHQIDTACYKTMTGLVDRFNKAVDSIVALEKGTSLPAERLNK 106
            :...||.||..:..:..||.:.  ...:|.....:..|...||:......:...| |...:.|.:
 Worm    71 VFQMIKGVCSLVKQLVVAFPKG--WDQNTPSISEIAALTKSFNRVAKPFASNWSG-SYNTDTLKE 132

  Fly   107 FAHPS----LLRHILQLVYNAAVLDPDKLNQ-YEPFSPEVYGETSYELVQQMLKHVTVSKEDTFI 166
            :..|:    :.:.|....|..||..|..||| |:.|:.|.||||:.|.:..::..:.:..:|.|:
 Worm   133 WGEPNCSAEVAKAITTYAYECAVPRPADLNQHYKSFTSETYGETNPEQLISIIDELNIGPQDVFV 197

  Fly   167 DLGSGVGQVVLQMAGSFPLKTCIGIEKADTPARYAERMDVIFRQYMGWFGKRFCEYKLIKGDFLV 231
            |||||:||:|...|.....|..:|||.:..|:.:|:.:...|:::|..|||...:::.|:||||.
 Worm   198 DLGSGIGQLVCLTAAYAKCKKSVGIELSQVPSNFAQDLAGYFKKFMSHFGKNHGKFEHIQGDFLN 262

  Fly   232 DEHRENI-TSSTLVFVNNFAFGPTVDHQLK-ERFADLRDGARVVSSKSFCPLNFRITDRNLSDIG 294
            .:.::.| ..:|::|:|||||...:..::. |...||:.|.|:|::|........||.|:.|||.
 Worm   263 PKFKQLICEEATVIFINNFAFDAALMLRINTELLQDLKHGTRIVTTKELGTNKKEITFRSTSDIN 327

  Fly   295 TIMHVSEIPPLKGSVSWTCKPVSYYLHVIDRTILERYFQ----RLKTKGGNDHESVGTVR---TT 352
            .|.|.:|:...:.:||||...|.::|..||.|.|.:|::    |.:.|...:...:...|   ..
 Worm   328 AISHTTELKTTESAVSWTSSHVKFWLTTIDHTKLIKYYEDQRRRQEVKSSREGSEISDGRDMGLK 392

  Fly   353 RDRAKREANVGQHHHNNHHSNNHANSNNHQRDR--EQSNGATATAAHQQR------HQSQSPANV 409
            :.:::||::|   |.:.......|.:::||..:  |.....|..|...::      .|..:||:
 Worm   393 KRKSQRESSV---HPDKLQKTEQAAASSHQSPKWNEPDTDYTPPAKKPKKEKLLREQQDATPAS- 453

  Fly   410 SGAGIVLAASGQQAASKTRQQLQHQHNQQQRSLDMESSTESDGDATNGNGGNTTTATNTTSASNG 474
                                  .|.|.       ..||:..|.:.......|.............
 Worm   454 ----------------------SHHHG-------ASSSSGKDREKEKEKKKNKIYEEKKVKTPKP 489

  Fly   475 PMTRKVWSDWCSSKGKSSQSDDEENNNSNSNGGSNGGSIGGGSVGR------------------- 520
            |.:        ||...||::....:::..||..|:...:...|..:
 Worm   490 PKS--------SSSRYSSETPTSHHHHHRSNSISHSSDVIRPSQPKATAPPPPLVPAPARATAST 546

  Fly   521 ------QARATTQKKRKKL------------------------TRKAAIASKSAAAAQREAEAAA 555
                  .|||.:.|:.:.|                        .|:||..|..|||.|    .|.
 Worm   547 PPPAPPAARAQSPKREEPLEPPTDLIHHGGGQLDAKTMNALHTIREAATTSAQAAAIQ----DAI 607

  Fly   556 AAAVSVPSKESSSKEDPPRAASAGPGRKGRMKKGARGRKSLKIVGLEALHKQTVLSTSLDTMTKK 620
            .:.:|.|::.|.|...||.|....|                           ..:..:.......
 Worm   608 NSVLSQPTEASPSAFGPPLAHLPAP---------------------------VAIYPTPPPPPAP 645

  Fly   621 LPAAPGTVDQQLTALLTENMSHAELDIPTAPQDTPYALQI---------------LLDVFRSQYT 670
            .||||    ||.:|            .|.||...|...:|               ..::..|.|.
 Worm   646 APAAP----QQASA------------APAAPNVMPVCTEIAAEQRHTFMIPPTDPFYNMIVSYYF 694

  Fly   671 SMIEHMKSS-----AYVPQVQKQIAQEQERMARLKNRASQLDKQIKVLIDDSVALLKVRMNELGI 730
            :|.:....|     .:|.:::..|..|:.|.|.||...:....||..|:...|..||.|::|||:
 Worm   695 AMKQFCNQSKTADPEFVGRLRLDIEAEEARRAELKESITLTSTQIDELLATGVNTLKSRLDELGM 759

  Fly   731 -HVNSPNDLIAQAKEIVGRHKDLQHTASRMRNEVTFYEGEQKLLL 774
             .|....:|:|.:|:||.:||.|.:|.::|.|.|..  .||||.|
 Worm   760 PSVTDVTELLAGSKQIVTQHKGLTNTVAQMENSVAV--EEQKLRL 802

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gpp	NP_731085.2	DOT1	121..323	CDD:149273	72/204 (35%)
		CC_DOT1L	657..721	CDD:411016	16/83 (19%)
dot-1.1	NP_740808.2	DOT1	151..356	CDD:149273	72/204 (35%)