DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gpp and dot-1.1

DIOPT Version :9

Sequence 1:	NP_731085.2	Gene:	gpp / 40793	FlyBaseID:	FBgn0264495	Length:	2137	Species:	Drosophila melanogaster
Sequence 2:	NP_740808.2	Gene:	dot-1.1 / 171797	WormBaseID:	WBGene00021474	Length:	946	Species:	Caenorhabditis elegans

Alignment Length:	825	Identity:	196/825 - (23%)
Similarity:	322/825 - (39%)	Gaps:	185/825 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 IIDTIKFVCDELPSMSSAFEETNLHQIDTACYKTMTGLVDRFNKAVDSIVALEKGTSLPAERLNK 106
            :...||.||..:..:..||.:.  ...:|.....:..|...||:......:...| |...:.|.:
Worm    71 VFQMIKGVCSLVKQLVVAFPKG--WDQNTPSISEIAALTKSFNRVAKPFASNWSG-SYNTDTLKE 132

  Fly   107 FAHPS----LLRHILQLVYNAAVLDPDKLNQ-YEPFSPEVYGETSYELVQQMLKHVTVSKEDTFI 166
            :..|:    :.:.|....|..||..|..||| |:.|:.|.||||:.|.:..::..:.:..:|.|:
Worm   133 WGEPNCSAEVAKAITTYAYECAVPRPADLNQHYKSFTSETYGETNPEQLISIIDELNIGPQDVFV 197

  Fly   167 DLGSGVGQVVLQMAGSFPLKTCIGIEKADTPARYAERMDVIFRQYMGWFGKRFCEYKLIKGDFLV 231
            |||||:||:|...|.....|..:|||.:..|:.:|:.:...|:::|..|||...:::.|:||||.
Worm   198 DLGSGIGQLVCLTAAYAKCKKSVGIELSQVPSNFAQDLAGYFKKFMSHFGKNHGKFEHIQGDFLN 262

  Fly   232 DEHRENI-TSSTLVFVNNFAFGPTVDHQLK-ERFADLRDGARVVSSKSFCPLNFRITDRNLSDIG 294
            .:.::.| ..:|::|:|||||...:..::. |...||:.|.|:|::|........||.|:.|||.
Worm   263 PKFKQLICEEATVIFINNFAFDAALMLRINTELLQDLKHGTRIVTTKELGTNKKEITFRSTSDIN 327

  Fly   295 TIMHVSEIPPLKGSVSWTCKPVSYYLHVIDRTILERYFQ----RLKTKGGNDHESVGTVR---TT 352
            .|.|.:|:...:.:||||...|.::|..||.|.|.:|::    |.:.|...:...:...|   ..
Worm   328 AISHTTELKTTESAVSWTSSHVKFWLTTIDHTKLIKYYEDQRRRQEVKSSREGSEISDGRDMGLK 392

  Fly   353 RDRAKREANVGQHHHNNHHSNNHANSNNHQRDR--EQSNGATATAAHQQR------HQSQSPANV 409
            :.:::||::|   |.:.......|.:::||..:  |.....|..|...::      .|..:||:
Worm   393 KRKSQRESSV---HPDKLQKTEQAAASSHQSPKWNEPDTDYTPPAKKPKKEKLLREQQDATPAS- 453

  Fly   410 SGAGIVLAASGQQAASKTRQQLQHQHNQQQRSLDMESSTESDGDATNGNGGNTTTATNTTSASNG 474
                                  .|.|.       ..||:..|.:.......|.............
Worm   454 ----------------------SHHHG-------ASSSSGKDREKEKEKKKNKIYEEKKVKTPKP 489

  Fly   475 PMTRKVWSDWCSSKGKSSQSDDEENNNSNSNGGSNGGSIGGGSVGR------------------- 520
            |.:        ||...||::....:::..||..|:...:...|..:
Worm   490 PKS--------SSSRYSSETPTSHHHHHRSNSISHSSDVIRPSQPKATAPPPPLVPAPARATAST 546

  Fly   521 ------QARATTQKKRKKL------------------------TRKAAIASKSAAAAQREAEAAA 555
                  .|||.:.|:.:.|                        .|:||..|..|||.|    .|.
Worm   547 PPPAPPAARAQSPKREEPLEPPTDLIHHGGGQLDAKTMNALHTIREAATTSAQAAAIQ----DAI 607

  Fly   556 AAAVSVPSKESSSKEDPPRAASAGPGRKGRMKKGARGRKSLKIVGLEALHKQTVLSTSLDTMTKK 620
            .:.:|.|::.|.|...||.|....|                           ..:..:.......
Worm   608 NSVLSQPTEASPSAFGPPLAHLPAP---------------------------VAIYPTPPPPPAP 645

  Fly   621 LPAAPGTVDQQLTALLTENMSHAELDIPTAPQDTPYALQI---------------LLDVFRSQYT 670
            .||||    ||.:|            .|.||...|...:|               ..::..|.|.
Worm   646 APAAP----QQASA------------APAAPNVMPVCTEIAAEQRHTFMIPPTDPFYNMIVSYYF 694

  Fly   671 SMIEHMKSS-----AYVPQVQKQIAQEQERMARLKNRASQLDKQIKVLIDDSVALLKVRMNELGI 730
            :|.:....|     .:|.:::..|..|:.|.|.||...:....||..|:...|..||.|::|||:
Worm   695 AMKQFCNQSKTADPEFVGRLRLDIEAEEARRAELKESITLTSTQIDELLATGVNTLKSRLDELGM 759

  Fly   731 -HVNSPNDLIAQAKEIVGRHKDLQHTASRMRNEVTFYEGEQKLLL 774
             .|....:|:|.:|:||.:||.|.:|.::|.|.|..  .||||.|
Worm   760 PSVTDVTELLAGSKQIVTQHKGLTNTVAQMENSVAV--EEQKLRL 802

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gpp	NP_731085.2	DOT1	121..323	CDD:149273	72/204 (35%)
dot-1.1	NP_740808.2	DOT1	151..356	CDD:149273	72/204 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156808
Domainoid	1	1.000	133	1.000	Domainoid score	I3137
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D55132at33208
OrthoFinder	1	1.000	-	-		FOG0003132
OrthoInspector	1	1.000	-	-		otm14488
orthoMCL	1	0.900	-	-		OOG6_103524
Panther	1	1.100	-	-	LDO	PTHR21451
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5335
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.850