Protein Alignment Dmtn and TMCC2

DIOPT Version :10

• Sequence 1: NP_001163531.1
• Gene: Dmtn / 40792
• FlyBaseID: FBgn0037443
• Length: 679
• Species: Drosophila melanogaster
• Sequence 2: NP_055673.2
• Gene: TMCC2 / 9911
• HGNCID: 24239
• Length: 709
• Species: Homo sapiens
• Alignment Length: 768
• Identity: 252/768 - (32%)
• Similarity: 347/768 - (45%)
• Gaps: 208/768 - (27%)

  Fly    45 TEQMSRERASEAAAATQTAAATAGGATAHSAGGTAGGSAAATTTAGGATSGSGTASANTNSNSSA 109
            ::::.:::..|..|..:.||:...||... .|.|.|.:     :|||.||.:|.|:|......|.
Human     6 SDELQQQQGEEDGAGLEDAASHLPGADLR-PGETTGAN-----SAGGPTSDAGAAAAPNPGPRSK 64

  Fly   110 SSSTVAAAQAAVYSGGNTVTGSLGSAGVVARGFRSHSPTHRRRSRERQRRT------HGSDQGGL 168
            ........|.:        .||:...|:      .|....|||||||:.:|      |...||
Human    65 PPDLKKIQQLS--------EGSMFGHGL------KHLFHSRRRSREREHQTSQDSQQHQQQQG-- 113

  Fly   169 LAYSGLVGVNDMTDFLGP-----------------------------------------QQGGGG 192
                       |:|...|                                         ::|...
Human   114 -----------MSDHDSPDEKERSPEMHRVSYAMSLHDLPARPTAFNRVLQQIRSRPSIKRGASL 167

  Fly   193 GGGGGGGGGGGGGSAGTGSGLEDSRLSGNEDYYSSFVSDEFDSSKKVHRRCHERSSSV------- 250
            ....|||..|........|.||..|  |:.........|...::.....:|..||||.
Human   168 HSSSGGGSSGSSSRRTKSSSLEPQR--GSPHLLRKAPQDSSLAAILHQHQCRPRSSSTTDTALLL 230

  Fly   251 --------------------------------------------------------QAIDRLNTK 259
                                                                    .|||.|:.|
Human   231 ADGSNVYLLAEEAEGIGDKVDKGDLVALSLPAGHGDTDGPISLDVPDGAPDPQRTKAAIDHLHQK 295

  Fly   260 IQCTKESIRQEQTARDDNVNEYLKLAASADKQQLQRIKAVFEKKNQKSAHNISQLQKKLDNYTKR 324
            |....|.|:.||.||||||.||||||.:|||||:.|||.||||||||||..|:||.|||::|.:|
Human   296 ILKITEQIKIEQEARDDNVAEYLKLANNADKQQVSRIKQVFEKKNQKSAQTIAQLHKKLEHYRRR 360

  Fly   325 AKDLQNHQFQTKSQHRQPREVLRDVGQGLRNVGGNIRDGITGFSG-------------------S 370
            .|:::.:     ...|||::||||:.|||::||.|:|.||:||.|                   :
Human   361 LKEIEQN-----GPSRQPKDVLRDMQQGLKDVGANVRAGISGFGGGVVEGVKGSLSGLSQATHTA 420

  Fly   371 VMSKPREFAHLIKNKFGSADNINQMSEAELQGMQSANADVL-GSERLQQVPGAGT-------STG 427
            |:|||||||.||:|||||||||..:.:....|.....|..| ||..|...|..|:       |..
Human   421 VVSKPREFASLIRNKFGSADNIAHLKDPLEDGPPEEAARALSGSATLVSSPKYGSDDECSSASAS 485

  Fly   428 SGGGGQNNNTGGAGS-GTGKFNSDNGSECSSVTSESIPGGSGKSQSGASQYHIVLKTLLTELAER 491
            |.|.|.|:..|..|: |:.|.|:..|:          ||.              |..||.||.|.
Human   486 SAGAGSNSGAGPGGALGSPKSNALYGA----------PGN--------------LDALLEELREI 526

  Fly   492 KAENEKLKERIERLETG-QKEFNNLTATLESERYRAEGLEEQINDLTELHQNEIENLKQTIADME 555
            |.....|::.:|.|:|. |:::..:|..|:.||||.|.||||:||||||||||:.||||.:|.||
Human   527 KEGQSHLEDSMEDLKTQLQRDYTYMTQCLQEERYRYERLEEQLNDLTELHQNEMTNLKQELASME 591

  Fly   556 EKVQYQSDERLRDVNEVLENCQTRISKME-HMSQQQYVTVEGIDNSNARALVVKLINVVLTILQV 619
            |||.|||.||.||:.|.:|:|.||::|:| ...|||.|.:||::|:|||||:.|.|||:|.::.|
Human   592 EKVAYQSYERARDIQEAVESCLTRVTKLELQQQQQQVVQLEGVENANARALLGKFINVILALMAV 656

  Fly   620 VLLLVATAAGIIMPFLKTRVRVLTTFLSICFVIFVIRQWPDVQDIGSGLVRHL 672
            :|:.|:|.|..|.|.:|||:|:.:|.|.:..:..:.:.|    |..:.|:.|:
Human   657 LLVFVSTIANFITPLMKTRLRITSTTLLVLVLFLLWKHW----DSLTYLLEHV 705

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dmtn	NP_001163531.1	Tmemb_cc2	249..658	CDD:463036	196/501 (39%)
TMCC2	NP_055673.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..143		37/169 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	158..202		10/45 (22%)
		Tmemb_cc2	285..695	CDD:463036	195/438 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	444..500		14/55 (25%)