DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dmtn and tmcc2

DIOPT Version :9

Sequence 1:	NP_001163531.1	Gene:	Dmtn / 40792	FlyBaseID:	FBgn0037443	Length:	679	Species:	Drosophila melanogaster
Sequence 2:	NP_001072595.1	Gene:	tmcc2 / 780050	XenbaseID:	XB-GENE-492260	Length:	725	Species:	Xenopus tropicalis

Alignment Length:	739	Identity:	257/739 - (34%)
Similarity:	360/739 - (48%)	Gaps:	142/739 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 APNPNQNRDFVTLKPLRPSRGSS-----SNLRASRSPSASRSTEQMSRERASEAAAATQTAAATA 67
            |.|.|:..|...::.|  |.||.     .:|..||         :.||||..:||:......:|.
Frog    51 AINRNKPPDLKKIQQL--SEGSMFGHGLKHLFHSR---------RRSRERDHQAASEPPVLCSTP 104

  Fly    68 GGATAHSAGGTAGGSAAATTTAGGATSGSGTASANTNSNSSASSSTVAAAQAAVYSGGNTVTGSL 132
            |.:|....      :||..:::...::.....|...:..|.|.|.....|:...:   |.|...:
Frog   105 GPSTPQIQ------TAAPLSSSDHDSADEKERSPEMHRVSYAVSLHDLPARPTAF---NRVLQQI 160

  Fly   133 GSAGVVARGFRSHSPTHRRRSRERQRRTH--------GSD---------QGGLLA----YSGLVG 176
            .|...|.||...|....|.:|.......|        ||.         .|||.|    :.|...
Frog   161 RSRPSVKRGSGQHGGGRRSKSGPGDTAHHQHHPPLRGGSPHLPRRPPPLDGGLAAVLHHHQGRPR 225

  Fly   177 VNDMTD--FLGPQQGGGGGGGGGGGGGGGG-------GSAGTGSGLEDSRLSGNEDYYSSFVSDE 232
            .:..||  .|......|.||..........       |...| .||..|.:.|         ..|
Frog   226 SSSTTDAALLASSDTIGAGGQAHEDQDRAAEKQQLDKGDLST-LGLPPSTVHG---------GSE 280

  Fly   233 FDSSKKVHRRCHERSSSVQAIDRLNTKIQCTKESIRQEQTARDDNVNEYLKLAASADKQQLQRIK 297
            .:.|.:|.....:...:..|:|.|:.||....|.|:.||.||||||.||||||.:||:||..|||
Frog   281 GNISLEVPEGAPDPQRTKAAMDHLHQKILKITEQIKIEQEARDDNVAEYLKLANNADRQQASRIK 345

  Fly   298 AVFEKKNQKSAHNISQLQKKLDNYTKRAKDLQNHQFQTKSQHRQPREVLRDVGQGLRNVGGNIRD 362
            .||||||||||..|:||.|||::|.|:.|:::.:...     |||::||||:.|||::||.|:|.
Frog   346 QVFEKKNQKSAQTIAQLHKKLEHYHKKLKEIEQNGIS-----RQPKDVLRDMQQGLKDVGANVRA 405

  Fly   363 GITGFSG-------------------SVMSKPREFAHLIKNKFGSADNINQMSEAELQGMQSANA 408
            ||:||.|                   :|:|||||||.||:|||||||||..:.:    |::
Frog   406 GISGFGGGVVEGVKGGLSGLSQVTHTAVVSKPREFASLIRNKFGSADNIPHLKD----GLE---- 462

  Fly   409 DVLGSERLQQVPGAGTSTGSGGGGQNNNTGGAGSGT----GKFNSDNGSECSSVTSESIPGG--S 467
                               ..|.||..|...:||.|    .|:.||:  ||||.||.|..||  |
Frog   463 -------------------EDGEGQGGNRALSGSATLAPSPKYGSDD--ECSSATSGSAGGGSNS 506

  Fly   468 GKSQSGASQ------------YHIVLKTLLTELAERKAENEKLKERIERLETG-QKEFNNLTATL 519
            |..|:|...            :|.....:|.||.|.|.....:::.:|.|::. |:::|.:|..|
Frog   507 GAGQAGPGSPRSNTLDAHHHGHHGGFDAILEELCEIKDGQSHIEDSMEDLKSQLQRDYNYMTQCL 571

  Fly   520 ESERYRAEGLEEQINDLTELHQNEIENLKQTIADMEEKVQYQSDERLRDVNEVLENCQTRISKME 584
            :.||||.|.||||:||||||||||:..|||.:|.|||||.|||.||.||:.|.:|:|.|||:|:|
Frog   572 QEERYRYERLEEQLNDLTELHQNEMTLLKQELASMEEKVAYQSYERARDIQEAVESCLTRITKLE 636

  Fly   585 -HMSQQQYVTVEGIDNSNARALVVKLINVVLTILQVVLLLVATAAGIIMPFLKTRVRVLTTFLSI 648
             ...|||.|.:||::::|||||:.|.|||:|.::.|:|:.|:|||..|.|.:|||:|:|::.|.:
Frog   637 LQQQQQQVVQLEGVESANARALLGKFINVLLALMAVLLVFVSTAASFITPLVKTRLRLLSSLLFL 701

  Fly   649 CFVIFVIRQWPDVQDIGSGLVRHL 672
            ..::.:.|.|    |..:..:.|:
Frog   702 LSLLTLWRHW----DCVTSCLEHV 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dmtn	NP_001163531.1	Tmemb_cc2	253..658	CDD:287269	194/443 (44%)
tmcc2	NP_001072595.1	Tmemb_cc2	301..689	CDD:313493	187/421 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	319	1.000	Domainoid score	I1244
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	319	1.000	Inparanoid score	I2485
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1175041at2759
OrthoFinder	1	1.000	-	-		FOG0001642
OrthoInspector	1	1.000	-	-		otm47421
Panther	1	1.100	-	-	LDO	PTHR17613
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1199
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160