Protein Alignment Dmtn and Tmcc2

DIOPT Version :10

• Sequence 1: NP_001163531.1
• Gene: Dmtn / 40792
• FlyBaseID: FBgn0037443
• Length: 679
• Species: Drosophila melanogaster
• Sequence 2: NP_849205.1
• Gene: Tmcc2 / 68875
• MGIID: 1916125
• Length: 706
• Species: Mus musculus
• Alignment Length: 750
• Identity: 254/750 - (33%)
• Similarity: 355/750 - (47%)
• Gaps: 175/750 - (23%)

  Fly    45 TEQMSRERASEAAAATQTAAATAGGATAHSAGGTAGGSAAATTTAGGATSGSGTASANTNSNSSA 109
            ::::.:::..|..|..:.||....||....      |.|::..:|||.||.:|.|.|......|.
Mouse     6 SDELQQQQGEEDGAGMEDAACLLPGADLRH------GEASSANSAGGPTSDAGAAVAPNPGPRSK 64

  Fly   110 SSSTVAAAQAAVYSGGNTVTGSLGSAGVVARGFRSHSPTHRRRSRER----------QRRTHG-S 163
            ........|.:        .||:...|:      .|....|||||||          |::..| |
Mouse    65 PPDLKKIQQLS--------EGSMFGHGL------KHLFHSRRRSREREHQASQEAQQQQQQQGLS 115

  Fly   164 DQGG---------LLAYSGLVGVNDM----TDFLGPQQ-----GGGGGGGGGGGGGGGGGSAGTG 210
            ||..         :...|..|.::|:    |.|....|     .....|......||.||.....
Mouse   116 DQDSPDEKERSPEMHRVSYAVSLHDLPARPTAFNRVLQQIRSRPSIKRGASLHSSGGSGGRRAKS 180

  Fly   211 SGLE--------------DSRLS------------------------GNEDYY----SSFVSDEF 233
            |.||              ||.|:                        |:..|.    :..:.|:.
Mouse   181 SSLEPQRGSPHLLRKAPQDSSLAAILHQHQGRPRSSSTTDTALLLADGSSAYLLAEEAESIGDKG 245

  Fly   234 DS---------------------SKKVHRRCHERSSSVQAIDRLNTKIQCTKESIRQEQTARDDN 277
            |.                     |..|.....:...:..||:.|:.||....|.|:.||.|||||
Mouse   246 DKGDLVALSLPSGPGHGDSDGPISLDVPDGAPDPQRTKAAIEHLHQKILKITEQIKIEQEARDDN 310

  Fly   278 VNEYLKLAASADKQQLQRIKAVFEKKNQKSAHNISQLQKKLDNYTKRAKDLQNHQFQTKSQHRQP 342
            |.||||||.:|||||:.|||.||||||||||..|:||.|||::|.:|.|:::.:     ...|||
Mouse   311 VAEYLKLANNADKQQVSRIKQVFEKKNQKSAQTIAQLHKKLEHYRRRLKEIEQN-----GPSRQP 370

  Fly   343 REVLRDVGQGLRNVGGNIRDGITGFSG-------------------SVMSKPREFAHLIKNKFGS 388
            ::||||:.|||::||.|:|.||:||.|                   :|:|||||||.||:|||||
Mouse   371 KDVLRDMQQGLKDVGANMRAGISGFGGGVVEGVKGSLSGLSQATHTAVVSKPREFASLIRNKFGS 435

  Fly   389 ADNINQMSEAELQGMQSANADVL-GSERLQQVPGAGT-------STGSGGGGQNNNTGGAGS-GT 444
            ||||..:.:....|.....|..| ||..|...|..|:       |..|.|.|.|:..|..|: |:
Mouse   436 ADNIAHLKDPMEDGPPEEAARALSGSATLVSSPKYGSDDECSSASASSAGAGSNSGAGPGGALGS 500

  Fly   445 GKFNSDNGSECSSVTSESIPGGSGKSQSGASQYHIVLKTLLTELAERKAENEKLKERIERLETG- 508
            .:.|:..|:          ||.              |.|||.||.|.|.....|::.:|.|:|.
Mouse   501 PRSNTLYGA----------PGN--------------LDTLLEELREIKEGQSHLEDSMEDLKTQL 541

  Fly   509 QKEFNNLTATLESERYRAEGLEEQINDLTELHQNEIENLKQTIADMEEKVQYQSDERLRDVNEVL 573
            |:::..:|..|:.||||.|.||||:||||||||||:.||||.:|.|||||.|||.||.||:.|.:
Mouse   542 QRDYTYMTQCLQEERYRYERLEEQLNDLTELHQNEMTNLKQELASMEEKVAYQSYERARDIQEAV 606

  Fly   574 ENCQTRISKME-HMSQQQYVTVEGIDNSNARALVVKLINVVLTILQVVLLLVATAAGIIMPFLKT 637
            |:|.||::|:| ...|||.|.:||::|:|||||:.|.|||:|.::.|:|:.|:|.|..|.|.:||
Mouse   607 ESCLTRVTKLELQQQQQQVVQLEGVENANARALLGKFINVILALMAVLLVFVSTIANFITPLMKT 671

  Fly   638 RVRVLTTFLSICFVIFVIRQWPDVQDIGSGLVRHL 672
            |:|:.:|.|.:..:..:.:.|..:    :.|:.|:
Mouse   672 RLRITSTALLLLVLFLLWKHWASL----TYLLEHV 702

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dmtn	NP_001163531.1	Tmemb_cc2	249..658	CDD:463036	194/438 (44%)
Tmcc2	NP_849205.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..221		51/234 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	251..280		2/28 (7%)
		Tmemb_cc2	282..692	CDD:463036	194/438 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	440..459		2/18 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	464..510		13/55 (24%)