Protein Alignment Dmtn and Tmcc1

DIOPT Version :9

• Sequence 1: NP_001163531.1
• Gene: Dmtn / 40792
• FlyBaseID: FBgn0037443
• Length: 679
• Species: Drosophila melanogaster
• Sequence 2: XP_036022146.1
• Gene: Tmcc1 / 330401
• MGIID: 2442368
• Length: 693
• Species: Mus musculus
• Alignment Length: 716
• Identity: 237/716 - (33%)
• Similarity: 335/716 - (46%)
• Gaps: 190/716 - (26%)

  Fly     1 MDTTPNAAPNPNQNRDFVTLK-PLRPSRGSSSNLRASRSPSASRSTEQMSRERASEAAAATQTAA 64
            :.|.|.|.     ||....:: |.:..||:|.:.|..:| .|.:.:.|::|:...|.||..|
Mouse    95 VSTHPTAL-----NRVLQQIRVPPKMKRGTSLHSRRGKS-EAPKGSPQINRKSGQEVAAVIQ--- 150

  Fly    65 ATAGGATAHSAGGTAGGSAAATTTAGGATSGSGTASANTNSNSSASSSTVAAAQAAVYSGGNTVT 129
                                         ||...:|:.|::.:|:|...:|.|
Mouse   151 -----------------------------SGRPRSSSTTDAPTSSSVMEIACA------------ 174

  Fly   130 GSLGSAGVVARGFRSHSPTHRRRSRERQRRTHGSDQGGLLAYSGLVGVNDMTDFLGP-------- 186
                 |||...|        ...:.||                       :.||.||
Mouse   175 -----AGVCVPG--------EEATAER-----------------------LEDFTGPLMAEVQAE 203

  Fly   187 ----QQGGGGGGGGGGGGGGGGGSAGTGSGLEDSRLSGNEDY---------------YSSFVSDE 232
                :|                 .:|....||:...:.:.||               .||.|:..
Mouse   204 SQKSKQ-----------------VSGKQCILEEGASARSLDYKSWKIERLEVSSLAQTSSAVASS 251

  Fly   233 FDSSKKVHRRCHERSSSVQ----AIDRLNTKIQCTKESIRQEQTARDDNVNEYLKLAASADKQQL 293
            .|.|  :|....:.....|    ||..|..||....|.|:..||||||||.||||||.||||||.
Mouse   252 TDGS--IHTESVDGIPDPQRTKAAIAHLQQKILKLTEQIKIAQTARDDNVAEYLKLANSADKQQA 314

  Fly   294 QRIKAVFEKKNQKSAHNISQLQKKLDNYTKRAKDLQNHQFQTKSQHRQPREVLRDVGQGLRNVGG 358
            .|||.||||||||||..|.||||||::|.::.::::.:...     |||::|.||:.|||::||.
Mouse   315 ARIKQVFEKKNQKSAQTILQLQKKLEHYHRKLREVEQNGIP-----RQPKDVFRDMHQGLKDVGA 374

  Fly   359 -----------NIRDGITGFS-------GSVMSKPREFAHLIKNKFGSADNINQMSEAELQGMQS 405
                       :::.|.:.||       |:|:|||||.|.||:|||||||||..:.::..:|...
Mouse   375 KVTGFSEGVVDSVKGGFSSFSQATHSAAGAVVSKPREIASLIRNKFGSADNIPNLKDSLEEGQVD 439

  Fly   406 ANADVLG-SERLQQVPGAG-----TSTGSGGGGQNNNTGGAGSGTGKFNSDNGSECSSVTSESIP 464
            .....|| ....|..|..|     :|..||..|.|:.|||...|.      :.|:.:::..:|
Mouse   440 DGGKALGVISNFQSSPKYGSEEDCSSATSGSVGANSTTGGIAVGA------SSSKTNTLDMQS-- 496

  Fly   465 GGSGKSQSGASQYHIVLKTLLTELAERKAENEKLKERIERL-ETGQKEFNNLTATLESERYRAEG 528
                   ||       ...||.|:.|.:....:|::..|.| |..|::::.:..||:.||||.|.
Mouse   497 -------SG-------FDALLHEVQEIRETQARLEDSFETLKEHYQRDYSLIMQTLQEERYRCER 547

  Fly   529 LEEQINDLTELHQNEIENLKQTIADMEEKVQYQSDERLRDVNEVLENCQTRISKME-HMSQQQYV 592
            ||||:|||||||||||.||||.:|.||||:.|||.||.||:.|.||.||||||||| ...|||.|
Mouse   548 LEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEACQTRISKMELQQQQQQVV 612

  Fly   593 TVEGIDNSNARALVVKLINVVLTILQVVLLLVATAAGIIMPFLKTRVRVLTTFLSICFVIFVIRQ 657
            .:||::|:.||.|:.||||::|.::.|:|:.|:|.|..::|.:|||.|..:|...:.|:.|:.:.
Mouse   613 QLEGLENATARNLLGKLINILLAVMAVLLVFVSTVANCVVPLMKTRNRTFSTLFLVAFIAFLWKH 677

  Fly   658 W 658
            |
Mouse   678 W 678

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dmtn	NP_001163531.1	Tmemb_cc2	253..658	CDD:287269	186/430 (43%)
Tmcc1	XP_036022146.1	Tmemb_cc2	271..678	CDD:402057	187/433 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830708
Domainoid	1	1.000	324	1.000	Domainoid score	I1191
eggNOG	1	0.900	-	-		E1_KOG3850
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	324	1.000	Inparanoid score	I2474
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1175041at2759
OrthoFinder	1	1.000	-	-		FOG0001642
OrthoInspector	1	1.000	-	-		otm42317
orthoMCL	1	0.900	-	-		OOG6_105734
Panther	1	1.100	-	-	O	PTHR17613
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3682
SonicParanoid	1	1.000	-	-		X1199
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.790