DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dmtn and Tmcc3

DIOPT Version :9

Sequence 1:	NP_001163531.1	Gene:	Dmtn / 40792	FlyBaseID:	FBgn0037443	Length:	679	Species:	Drosophila melanogaster
Sequence 2:	NP_001101554.1	Gene:	Tmcc3 / 314751	RGDID:	1307241	Length:	477	Species:	Rattus norvegicus

Alignment Length:	434	Identity:	169/434 - (38%)
Similarity:	242/434 - (55%)	Gaps:	62/434 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   254 DRLNTKIQCTKESIRQEQTARDDNVNEYLKLAASADKQQLQRIKAVFEKKNQKSAHNISQLQKKL 318
            |.|..||....|.|:.|||:||.||.|||||.:||||||..|||.|||||||||||:|:||||||
  Rat    69 DSLRQKILKVTEQIKIEQTSRDGNVAEYLKLVSSADKQQAGRIKQVFEKKNQKSAHSIAQLQKKL 133

  Fly   319 DNYTKRAKDLQNHQFQTKSQHRQPREVLRDVGQGLRNVGGNIR----------DGITGFSGS--- 370
            :.|.::.::::.:. .|:|.....::.|:::...|::.....|          ..:.|.|.:
  Rat   134 EQYHRKLREIEQNG-ATRSSKDISKDSLKEIQHSLKDAHVKSRTAPHCLESSKSSMPGVSLTPPV 197

  Fly   371 -VMSKPREFAHLIKNKFGSADNI----NQMSEAELQGMQSANADVLGSERLQQVPGAGTSTGSGG 430
             |.:|.||||:||:|||||||||    |.:.|...:....|..   ||..:...|
  Rat   198 FVFNKSREFANLIRNKFGSADNIAHLKNSLEEFRPEASPRAYG---GSATIVNKP---------- 249

  Fly   431 GGQNNNTGGAGSGTGKFNSDNGSECSSVTSESIPG------GSGKSQSGASQYHIVLKTLLTELA 489
                           |:.||:  ||||.||.|...      |:|.:.:..||..:.:  :|.||.
  Rat   250 ---------------KYGSDD--ECSSGTSGSADSNGNQSFGAGGASTLDSQGKLAI--ILEELR 295

  Fly   490 ERKAENEKLKERIERLETG-QKEFNNLTATLESERYRAEGLEEQINDLTELHQNEIENLKQTIAD 553
            |.|....:|.|.||.|:.. ::|:..::.||:.||||.|.||:|::|||||||:|..||||.:|.
  Rat   296 EIKVTQAQLAEDIEALKVQFKREYGFISQTLQEERYRYERLEDQLHDLTELHQHETANLKQELAS 360

  Fly   554 MEEKVQYQSDERLRDVNEVLENCQTRISKME-HMSQQQYVTVEGIDNSNARALVVKLINVVLTIL 617
            .||||.||:.||.||:.|.||:|||||||:| |..:||.:..:.:   ||:.|:.|.|||||..:
  Rat   361 AEEKVAYQAYERSRDIQEALESCQTRISKLELHQQEQQTLQTDAV---NAKVLLGKCINVVLAFM 422

  Fly   618 QVVLLLVATAAGIIMPFLKTRVRVLTTFLSICFVIFVIRQWPDV 661
            .|:|:.|:|.|..:.|.:|:|..:|.||.::..:....:.|..:
  Rat   423 TVILVCVSTLAKFVSPMMKSRSHILGTFFAVTLLAIFCKNWDHI 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dmtn	NP_001163531.1	Tmemb_cc2	253..658	CDD:287269	168/429 (39%)
Tmcc3	NP_001101554.1	Tmemb_cc2	69..463	CDD:287269	168/429 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334420
Domainoid	1	1.000	324	1.000	Domainoid score	I1165
eggNOG	1	0.900	-	-		E1_KOG3850
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	324	1.000	Inparanoid score	I2406
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1175041at2759
OrthoFinder	1	1.000	-	-		FOG0001642
OrthoInspector	1	1.000	-	-		otm44373
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR17613
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1199
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.860