Protein Alignment Dmtn and Tmcc1

DIOPT Version :10

• Sequence 1: NP_001163531.1
• Gene: Dmtn / 40792
• FlyBaseID: FBgn0037443
• Length: 679
• Species: Drosophila melanogaster
• Sequence 2: XP_038964964.1
• Gene: Tmcc1 / 312654
• RGDID: 1311909
• Length: 693
• Species: Rattus norvegicus
• Alignment Length: 697
• Identity: 240/697 - (34%)
• Similarity: 336/697 - (48%)
• Gaps: 152/697 - (21%)

  Fly     1 MDTTPNAAPNPNQNRDFVTLK-PLRPSRGSSSNLRASRSPSASRSTEQMSRERASEAAAATQTAA 64
            :.|.|.|.     ||....:: |.:..||:|.:.|..:| .|.:.:.|::|:...|.|:..|
  Rat    95 VSTHPTAL-----NRVLQQIRVPPKMKRGTSLHSRRGKS-EAPKGSPQINRKSGQEVASVIQ--- 150

  Fly    65 ATAGGATAHSAGGTAGGSAAATTTAGGATSGSGTASANTNSNSSASSSTVAAAQAAVYSGGNTVT 129
                                         ||...:|:.|::.:|:|...:|.| |||...|...|
  Rat   151 -----------------------------SGRPRSSSTTDAPTSSSVIEIACA-AAVCVPGEEAT 185

  Fly   130 --------GSLGSAGVVARGFRSHSPTHRRRSRERQRRTHGSDQGGLLAYSGLVGVNDMTDFLGP 186
                    |.| .|||.|...:|.....::...|.:......|.
  Rat   186 AERLEYFPGPL-VAGVKAESQKSKQVNGKQYMLEEEASAWALDY--------------------- 228

  Fly   187 QQGGGGGGGGGGGGGGGGGSAGTGSGLEDSRLSGNEDYYSSFVSDEFDSSKKVHRRCHERSSSVQ 251
                               .|.....||.|.|:..    ||.|:...|.|  :|....:.....|
  Rat   229 -------------------MACKIERLEVSSLAQT----SSAVASSTDGS--IHTESVDGIPDPQ 268

  Fly   252 ----AIDRLNTKIQCTKESIRQEQTARDDNVNEYLKLAASADKQQLQRIKAVFEKKNQKSAHNIS 312
                ||..|..||....|.|:..||||||||.||||||.||||||..|||.||||||||||..|.
  Rat   269 RTKAAIAHLQQKILKLTEQIKIAQTARDDNVAEYLKLANSADKQQAARIKQVFEKKNQKSAQTIL 333

  Fly   313 QLQKKLDNYTKRAKDLQNHQFQTKSQHRQPREVLRDVGQGLRNVGG-----------NIRDGITG 366
            ||||||::|.::.::::.:...     |||::|.||:.|||::||.           :::.|.:.
  Rat   334 QLQKKLEHYHRKLREVEQNGIP-----RQPKDVFRDMHQGLKDVGAKVTGFSEGVVDSVKGGFSS 393

  Fly   367 FS-------GSVMSKPREFAHLIKNKFGSADNINQMSEAELQGMQSANADVLG-SERLQQVPGAG 423
            ||       |:|:|||||.|.||:|||||||||..:.::..:|........|| ....|..|..|
  Rat   394 FSQATHSAAGAVVSKPREIASLIRNKFGSADNIPNLKDSLEEGQVDDGGKALGVISNFQSSPKYG 458

  Fly   424 -----TSTGSGGGGQNNNTGGAGSGTGKFNSDNGSECSSVTSESIPGGSGKSQSGASQYHIVLKT 483
                 :|..||..|.|:.|||...|.      :.|:.:::..:|         ||       ...
  Rat   459 SEEDCSSATSGSVGANSTTGGIAVGA------SSSKTNTLDMQS---------SG-------FDA 501

  Fly   484 LLTELAERKAENEKLKERIERL-ETGQKEFNNLTATLESERYRAEGLEEQINDLTELHQNEIENL 547
            ||.|:.|.:....:|:|..|.| |..|::::.:..||:.||||.|.||||:|||||||||||.||
  Rat   502 LLHEVQEIRETQTRLEESFETLKEHYQRDYSLIMQTLQEERYRCERLEEQLNDLTELHQNEILNL 566

  Fly   548 KQTIADMEEKVQYQSDERLRDVNEVLENCQTRISKME-HMSQQQYVTVEGIDNSNARALVVKLIN 611
            ||.:|.||||:.|||.||.||:.|.||.||||||||| ...|||.|.:||::|:.||.|:.||||
  Rat   567 KQELASMEEKIAYQSYERARDIQEALEACQTRISKMELQQQQQQVVQLEGLENATARNLLGKLIN 631

  Fly   612 VVLTILQVVLLLVATAAGIIMPFLKTRVRVLTTFLSICFVIFVIRQW 658
            ::|.::.|:|:.|:|.|..::|.:|||.|..:|...:.|:.|:.:.|
  Rat   632 ILLAVMAVLLVFVSTVANCVVPLMKTRNRTFSTLFLVAFIAFLWKHW 678

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dmtn	NP_001163531.1	Tmemb_cc2	249..658	CDD:463036	189/438 (43%)
Tmcc1	XP_038964964.1	Tmemb_cc2	270..678	CDD:463036	188/434 (43%)