DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dmtn and TMCC1

DIOPT Version :9

Sequence 1:NP_001163531.1 Gene:Dmtn / 40792 FlyBaseID:FBgn0037443 Length:679 Species:Drosophila melanogaster
Sequence 2:NP_001017395.2 Gene:TMCC1 / 23023 HGNCID:29116 Length:653 Species:Homo sapiens


Alignment Length:663 Identity:227/663 - (34%)
Similarity:319/663 - (48%) Gaps:162/663 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 PLRPSRGSSSNLRASRSPSASRSTEQMSRERASEAAAATQTAAATAGGATAHSAGGTAGGSAAAT 86
            |.:..||:|.:.|..: |.|.:.:.|::|:...|..|..|                         
Human   112 PPKMKRGTSLHSRRGK-PEAPKGSPQINRKSGQEMTAVMQ------------------------- 150

  Fly    87 TTAGGATSGSGTASANTNSNSSASSSTVAAAQAAVYSGGNTVTGSLGSAGVVARGFRSHSPTHRR 151
                   ||...:|:.|::.:|::...:|.|.||  :....:.|..|:|                
Human   151 -------SGRPRSSSTTDAPTSSAMMEIACAAAA--AAAACLPGEEGTA---------------- 190

  Fly   152 RSRERQRRTHGSDQGGLLAYSGLVGVNDMTDFLGPQQGGGGGGGGGGGGGGGGGSAGTGSGLEDS 216
               ||..|         |..|.|                                |.|.|.:..|
Human   191 ---ERIER---------LEVSSL--------------------------------AQTSSAVASS 211

  Fly   217 RLSGNEDYYSSFVSDEFDSSKKVHRRCHERSSSVQAIDRLNTKIQCTKESIRQEQTARDDNVNEY 281
            .       ..|..:|..|.:....|       :..||..|..||....|.|:..||||||||.||
Human   212 T-------DGSIHTDSVDGTPDPQR-------TKAAIAHLQQKILKLTEQIKIAQTARDDNVAEY 262

  Fly   282 LKLAASADKQQLQRIKAVFEKKNQKSAHNISQLQKKLDNYTKRAKDLQNHQFQTKSQHRQPREVL 346
            ||||.||||||..|||.||||||||||..|.||||||::|.::.::::.:...     |||::|.
Human   263 LKLANSADKQQAARIKQVFEKKNQKSAQTILQLQKKLEHYHRKLREVEQNGIP-----RQPKDVF 322

  Fly   347 RDVGQGLRNVGG-----------NIRDGITGFS-------GSVMSKPREFAHLIKNKFGSADNIN 393
            ||:.|||::||.           :::.|.:.||       |:|:|||||.|.||:|||||||||.
Human   323 RDMHQGLKDVGAKVTGFSEGVVDSVKGGFSSFSQATHSAAGAVVSKPREIASLIRNKFGSADNIP 387

  Fly   394 QMSEAELQGMQSANADVLG-SERLQQVPGAG-----TSTGSGGGGQNNNTGGAGSGTGKFNSDNG 452
            .:.::..:|........|| ....|..|..|     :|..||..|.|:.|||...|.      :.
Human   388 NLKDSLEEGQVDDAGKALGVISNFQSSPKYGSEEDCSSATSGSVGANSTTGGIAVGA------SS 446

  Fly   453 SECSSVTSESIPGGSGKSQSGASQYHIVLKTLLTELAERKAENEKLKERIERL-ETGQKEFNNLT 516
            |:.:::..:|         ||       ...||.|:.|.:....:|:|..|.| |..|::::.:.
Human   447 SKTNTLDMQS---------SG-------FDALLHEIQEIRETQARLEESFETLKEHYQRDYSLIM 495

  Fly   517 ATLESERYRAEGLEEQINDLTELHQNEIENLKQTIADMEEKVQYQSDERLRDVNEVLENCQTRIS 581
            .||:.||||.|.||||:|||||||||||.||||.:|.||||:.|||.||.||:.|.||.||||||
Human   496 QTLQEERYRCERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEACQTRIS 560

  Fly   582 KME-HMSQQQYVTVEGIDNSNARALVVKLINVVLTILQVVLLLVATAAGIIMPFLKTRVRVLTTF 645
            ||| ...|||.|.:||::|:.||.|:.||||::|.::.|:|:.|:|.|..::|.:|||.|..:|.
Human   561 KMELQQQQQQVVQLEGLENATARNLLGKLINILLAVMAVLLVFVSTVANCVVPLMKTRNRTFSTL 625

  Fly   646 LSICFVIFVIRQW 658
            ..:.|:.|:.:.|
Human   626 FLVVFIAFLWKHW 638

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DmtnNP_001163531.1 Tmemb_cc2 253..658 CDD:287269 187/430 (43%)
TMCC1NP_001017395.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..35
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 58..78
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 112..165 16/85 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 204..227 6/29 (21%)
Tmemb_cc2 231..638 CDD:402057 188/433 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 415..437 7/21 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165140735
Domainoid 1 1.000 324 1.000 Domainoid score I1199
eggNOG 1 0.900 - - E1_KOG3850
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 324 1.000 Inparanoid score I2502
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1175041at2759
OrthoFinder 1 1.000 - - FOG0001642
OrthoInspector 1 1.000 - - otm40249
orthoMCL 1 0.900 - - OOG6_105734
Panther 1 1.100 - - O PTHR17613
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3682
SonicParanoid 1 1.000 - - X1199
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.790

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