DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gzl and rnf13

DIOPT Version :9

Sequence 1:	NP_001097695.1	Gene:	gzl / 40791	FlyBaseID:	FBgn0037442	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_957338.1	Gene:	rnf13 / 793981	ZFINID:	ZDB-GENE-040426-772	Length:	377	Species:	Danio rerio

Alignment Length:	352	Identity:	132/352 - (37%)
Similarity:	203/352 - (57%)	Gaps:	47/352 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 EEFNDLPAQFGPNLPSNGLKVYVVPARRPYYGCDSLDRPPHLKYPPSAKFVALVARGECVFERKI 104
            |.|:||||:||..|||.|||.:::.| ||...|..::.||..:...|| |:.|:.|.:|.|:.|:
Zfish    46 ENFDDLPARFGYRLPSEGLKGFLIGA-RPENACVPIEPPPQRENLSSA-FIVLIRRFDCNFDIKV 108

  Fly   105 RVAQNASYSAVIVYNNEGDDLEQMSAEN---ITGIRIPSVFVGHTTGKALATYFTTE----VVLI 162
            ..||.|.|.|.||:|.:.|||..|.:|:   :..|.|||||:|.....:|...:..|    |:|:
Zfish   109 LHAQKAGYKAAIVHNVDSDDLISMGSEDLDILKQIDIPSVFIGEEAANSLKEDYIYEKGGHVILM 173

  Fly   163 INDELPFNINTQLILPFSILIGMCFIIMVIYMIYKCIREQRRLRRHRLPKSMLKKLPVLRYTKNN 227
            .:..||..   ..::||.|::|:|.|::|::||.|.::::.|.||.||.|..|||||:.::.|.:
Zfish   174 PDFSLPLE---YYLIPFLIIVGICLILIVVFMITKFVQDRHRARRSRLRKDQLKKLPIHKFKKGD 235

  Fly   228 ANNKYDTCVICLEDFIEDDKLRVLPCSHPYHTHCIDPWLTENRRVCPICKRKVF-TKGEARASRS 291
            :   ||.|.|||:::.|.::||||||||.||..|:|||||:.::.||:||:||. :.|:   |.|
Zfish   236 S---YDVCAICLDEYEEGERLRVLPCSHAYHCKCVDPWLTKTKKTCPVCKQKVVPSDGD---SES 294

  Fly   292 RQPSLDNVTDTDD--DTTPLLQQQQSNGRQVGQVSSASSAGGAAGSSSSVAAAAVAGTTRHGTFR 354
            ...|:|:..:.::  :.||||:            |.||::..:.||.|       |..::|
Zfish   295 DSDSVDSGGEDNEVSENTPLLR------------SLASTSAHSFGSMS-------ASLSQH---- 336

  Fly   355 RGHAGRNPFEE-SQSSDDENALLASTV 380
              .||.:.::| |.|||.|..:...||
Zfish   337 --DAGSSDYDERSDSSDSEEEVTVETV 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gzl	NP_001097695.1	PA_C_RZF_like	14..171	CDD:239038	54/137 (39%)
gzl	NP_001097695.1	zf-RING_2	233..277	CDD:290367	24/43 (56%)
rnf13	NP_957338.1	PA_C_RZF_like	23..180	CDD:239038	53/135 (39%)
rnf13	NP_957338.1	zf-RING_2	238..282	CDD:290367	24/43 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	77	1.000	Domainoid score	I8792
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	209	1.000	Inparanoid score	I3657
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1487241at2759
OrthoFinder	1	1.000	-	-		FOG0001489
OrthoInspector	1	1.000	-	-		otm25895
orthoMCL	1	0.900	-	-		OOG6_103040
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1776
SonicParanoid	1	1.000	-	-		X670
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.900