DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gzl and Znrf3

DIOPT Version :9

Sequence 1:	NP_001097695.1	Gene:	gzl / 40791	FlyBaseID:	FBgn0037442	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	XP_038948772.1	Gene:	Znrf3 / 685487	RGDID:	1593771	Length:	913	Species:	Rattus norvegicus

Alignment Length:	507	Identity:	109/507 - (21%)
Similarity:	181/507 - (35%)	Gaps:	135/507 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 VYVVPARRPYYGCDSLDRPPHLKYPPSAKFVALVARGECVFERKIRVAQNASYSAVIVYNNEGDD 124
            |.||...:|     .||..|.|.....||                |..|..:.:.:...:...:.
  Rat   118 VGVVKLEQP-----ELDPKPCLTVLGKAK----------------RAVQRGATAVIFDVSENPEA 161

  Fly   125 LEQMSAENITGIRIPSVFV-GHTTGKALATYFTTEVVLIINDELPFNINTQ-----LILPFSILI 183
            ::|::..:...::.|.|:| |....|.:......:|.......||....|:     :.|.|.:::
  Rat   162 IDQLNQGSEDPLKRPVVYVKGADAVKLMNIVNKQKVARARIQHLPPRQPTEYFDMGIFLAFFVVV 226

  Fly   184 GMCFIIMVIYMIYKCIREQRRLRRHRLPKSMLKKLPVLRYTKNNANNK------YDT-------- 234
            .:..:|:::.:..|..|.|..:  :||....|:|:...::...:...:      .||
  Rat   227 SLVCLILLVKIKLKQRRSQNSM--NRLAVQALEKMETRKFNSKSKGRREGSCGALDTLSSGSTSD 289

  Fly   235 CVICLEDFIEDDKLRVLPCSHPYHTHCIDPWLTENRRVCPICKRKVF-TKGEARA--------SR 290
            |.||||.:|:.::|||:||:|.:|..|:||||.:: ..||.|:..:. .||...|        :|
  Rat   290 CAICLEKYIDGEELRVIPCTHRFHRKCVDPWLLQH-HTCPHCRHNIIEQKGNPGAVCVETSNLTR 353

  Fly   291 SRQPSLDNVTDTDDDTTPLLQQQQSNGRQVGQVSSASSAGGAAGSSSSVAAAAVAGTTRHG---- 351
            .|.|.:         |.|:    ...|| |.:.::..:........|......:....|||
  Rat   354 GRHPRV---------TLPV----HYPGR-VHRTNAIPAYPTRTSMDSHGNPVTLLTMDRHGEQNL 404

  Fly   352 ------TFRRGHAGRNPFEESQSSDDENALLASTVRPATSSGAHERINPFDRAPNLPAHLAEQLT 410
                  |:.||:.   |..           |..|:.|...|..|...:        |||...:..
  Rat   405 YSPQTPTYVRGYP---PLH-----------LDHTLAPHRCSLEHRAYS--------PAHPFRRPK 447

  Fly   411 ESRRSVWSRINFASF-------------FRRQ-----PAVI----SVAAPPYLERVESGTSAMGL 453
            .|.||......|:.:             :..|     |:|.    |.|.||      ||.|::..
  Rat   448 FSSRSFSKAACFSQYETMYQHYYFQGLSYPEQESQPVPSVTPRGQSRAFPP------SGGSSLLF 506

  Fly   454 PVTGTIAVASPASNNILNPNLSGSFKDEDDMPPHRSIYEPIAISTPAADSAT 505
            |.  .:.:|.||...      |||.........|||:........|.:||::
  Rat   507 PT--MVHMAPPAHVE------SGSTSSFSCYHGHRSVCSGYLADCPGSDSSS 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gzl	NP_001097695.1	PA_C_RZF_like	14..171	CDD:239038	21/111 (19%)
gzl	NP_001097695.1	zf-RING_2	233..277	CDD:290367	22/51 (43%)
Znrf3	XP_038948772.1	ZNRF_3_ecto	98..204	CDD:408039	19/106 (18%)
Znrf3	XP_038948772.1	RING-H2_ZNRF3	289..333	CDD:319713	21/44 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1487241at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010