DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gzl and Rnf13

DIOPT Version :9

Sequence 1:	NP_001097695.1	Gene:	gzl / 40791	FlyBaseID:	FBgn0037442	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_001102914.1	Gene:	Rnf13 / 681578	RGDID:	1594062	Length:	380	Species:	Rattus norvegicus

Alignment Length:	375	Identity:	136/375 - (36%)
Similarity:	202/375 - (53%)	Gaps:	51/375 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 QILTLLGLCLVCHEATL-VGGHVLVYRKATSQLIEEFNDLPAQFGPNLPSNGLKVYVVPARRPYY 70
            |:.|:|.:.|......| |...:|.|....:.  :.|.||||:||..||:.|||.:::.: :|..
  Rat    14 QVYTILTVQLFAFLNLLPVEADILAYNFENAS--QTFEDLPARFGYRLPAEGLKGFLINS-KPEN 75

  Fly    71 GCDSLDRPPHLKYPPSAKFVALVARGECVFERKIRVAQNASYSAVIVYNNEGDDLEQMSAENI-- 133
            .|:.: .||.||...|..|:.|:.|.:|.|:.|:..||.|.|.|.||:|.:.|||..|.:.:|
  Rat    76 ACEPI-VPPPLKDNSSGTFIVLIRRLDCNFDIKVLNAQRAGYKAAIVHNVDSDDLISMGSNDIDI 139

  Fly   134 -TGIRIPSVFVGHTTGKALATYFTTE----VVLIINDELPFNINTQLILPFSILIGMCFIIMVIY 193
             ..|.|||||:|.::..:|...||.|    |:|:....||..   ..::||.|::|:|.|::||:
  Rat   140 LKKIDIPSVFIGESSANSLKDEFTYEKGGHVILVPELSLPLE---YYLIPFLIIVGICLILIVIF 201

  Fly   194 MIYKCIREQRRLRRHRLPKSMLKKLPVLRYTKNNANNKYDTCVICLEDFIEDDKLRVLPCSHPYH 258
            ||.|.::::.|.||:||.|..||||||.::.|   .::||.|.||||::.:.||||:|||||.||
  Rat   202 MITKFVQDRHRNRRNRLRKDQLKKLPVHKFKK---GDEYDVCAICLEEYEDGDKLRILPCSHAYH 263

  Fly   259 THCIDPWLTENRRVCPICKRKVFTKGEARASRSRQPSLDNVTDTDDDTTPLLQQQQSNGRQVGQV 323
            ..|:|||||:.::.||:||:||.            ||..   |:|.||.   ..|:.|     ||
  Rat   264 CKCVDPWLTKTKKTCPVCKQKVV------------PSQG---DSDSDTD---SSQEEN-----QV 305

  Fly   324 SSASSAGGAAGSSSSVAAAAVAGTTRHGTFRRGHAGRNPFEESQSSDDEN 373
            |.         .:..:..:|.|.|...|:....|: .:..|.|...||:|
  Rat   306 SE---------HTPLLPPSASARTQSFGSLSESHS-HHMTESSDYEDDDN 345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gzl	NP_001097695.1	PA_C_RZF_like	14..171	CDD:239038	58/164 (35%)
gzl	NP_001097695.1	zf-RING_2	233..277	CDD:290367	25/43 (58%)
Rnf13	NP_001102914.1	PA_C_RZF_like	23..180	CDD:239038	57/160 (36%)
		RING-H2_RNF167	238..283	CDD:319711	26/44 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	285..380		22/94 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	76	1.000	Domainoid score	I8729
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	210	1.000	Inparanoid score	I3584
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1487241at2759
OrthoFinder	1	1.000	-	-		FOG0001489
OrthoInspector	1	1.000	-	-		otm45328
orthoMCL	1	0.900	-	-		OOG6_103040
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X670
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.870