DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gzl and Rnf130

DIOPT Version :9

Sequence 1:	NP_001097695.1	Gene:	gzl / 40791	FlyBaseID:	FBgn0037442	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_001277679.1	Gene:	Rnf130 / 59044	MGIID:	1891717	Length:	419	Species:	Mus musculus

Alignment Length:	369	Identity:	98/369 - (26%)
Similarity:	157/369 - (42%)	Gaps:	81/369 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 LPSNGLKVYVVPARRPYYGCDSLDR---PPHLKYPPSAKFVALVARGECVFERKIRVAQNASYSA 114
            ||.:|:        ..:.|||...|   ||::|     :::||:.||.|.|:.||..|...:..|
Mouse    78 LPIHGV--------ADHLGCDPQTRFFVPPNIK-----QWIALLQRGNCTFKEKISRAAFHNAVA 129

  Fly   115 VIVYNNEGDDLEQMSAENITGIRIPSVFVGHTTGKALATYFTTEVVLIINDELPFNINTQLILP- 178
            |::|||:..:.........|| .|.:|.:....||.:.:|            |..||:.|:.:.
Mouse   130 VVIYNNKSKEEPVTMTHPGTG-DIIAVMITELRGKDILSY------------LEKNISVQMTIAV 181

  Fly   179 --------FS----ILIGMCFIIMVI--------YMIYKC------IREQRRLRRHRLPKSMLKK 217
                    ||    :.:.:.||:::|        |.|.|.      .|.||||  ....|..:.|
Mouse   182 GTRMPPKNFSRGSLVFVSISFIVLMIISSAWLIFYFIQKIRYTNARDRNQRRL--GDAAKKAISK 244

  Fly   218 LPVLRYTKNN--ANNKYDTCVICLEDFIEDDKLRVLPCSHPYHTHCIDPWLTENRRVCPICKRKV 280
            |......|.:  .:..:|.|.:|:|.:.::|.:|||||.|.:|..|:||||:|: ..||:||..:
Mouse   245 LTTRTVKKGDKETDPDFDHCAVCIESYKQNDVVRVLPCKHVFHKSCVDPWLSEH-CTCPMCKLNI 308

  Fly   281 FTKGEARASRSRQPSLDNVTDTDDDTTPLLQQQQSNGR-QVGQVSSASSAGGAAGSSSSVAAAA- 343
            .   :|.......|..|||.   .|...|.:.|..|.| .:|.::..||.|.....:|.::...
Mouse   309 L---KALGIVPNLPCTDNVA---FDMERLTRTQAVNRRAALGDLAGDSSLGLEPLRTSGISPLPQ 367

  Fly   344 ------------VAGTTRHGTFRRGHAGRNPFEESQSSDDENAL 375
                        :|.|:.|...:...:.|:...||:.|..|.:|
Mouse   368 DGELTPRTGEINIAVTSGHVFHQNSLSPRSLVYESEFSTIEPSL 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gzl	NP_001097695.1	PA_C_RZF_like	14..171	CDD:239038	32/120 (27%)
gzl	NP_001097695.1	zf-RING_2	233..277	CDD:290367	20/43 (47%)
Rnf130	NP_001277679.1	PA_GRAIL_like	40..179	CDD:239037	35/126 (28%)
		HRD1	<197..>306	CDD:227568	36/111 (32%)
		RING-H2_RNF130	262..310	CDD:319717	22/51 (43%)
		RING-H2 finger (C3H2C3-type)	264..304	CDD:319717	19/40 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1487241at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920