DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gzl and RNF130

DIOPT Version :9

Sequence 1:	NP_001097695.1	Gene:	gzl / 40791	FlyBaseID:	FBgn0037442	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	XP_024301897.1	Gene:	RNF130 / 55819	HGNCID:	18280	Length:	448	Species:	Homo sapiens

Alignment Length:	388	Identity:	101/388 - (26%)
Similarity:	162/388 - (41%)	Gaps:	101/388 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 LPSNGLKVYVVPARRPYYGCDSLDR---PPHLKYPPSAKFVALVARGECVFERKIRVAQNASYSA 114
            ||.:|:        ..:.|||...|   ||::|     :::||:.||.|.|:.||..|...:..|
Human    78 LPLHGV--------ADHLGCDPQTRFFVPPNIK-----QWIALLQRGNCTFKEKISRAAFHNAVA 129

  Fly   115 VIVYNNEGDDLEQMSAENITGIRIPSVFVGHTTGKALATYFTTEVVLIINDELPFNINTQLILP- 178
            |::|||:..:.........|| .|.:|.:....||.:.:|            |..||:.|:.:.
Human   130 VVIYNNKSKEEPVTMTHPGTG-DIIAVMITELRGKDILSY------------LEKNISVQMTIAV 181

  Fly   179 --------FS----ILIGMCFIIMVI--------YMIYKC------IREQRRLRRHRLPKSMLKK 217
                    ||    :.:.:.||:::|        |.|.|.      .|.||||  ....|..:.|
Human   182 GTRMPPKNFSRGSLVFVSISFIVLMIISSAWLIFYFIQKIRYTNARDRNQRRL--GDAAKKAISK 244

  Fly   218 LPVLRYTKNN--ANNKYDTCVICLEDFIEDDKLRVLPCSHPYHTHCIDPWLTENRRVCPICKRKV 280
            |......|.:  .:..:|.|.:|:|.:.::|.:|:|||.|.:|..|:||||:|: ..||:||..:
Human   245 LTTRTVKKGDKETDPDFDHCAVCIESYKQNDVVRILPCKHVFHKSCVDPWLSEH-CTCPMCKLNI 308

  Fly   281 FTKGEARASRSRQPSLDNVTDTDDDTTPLLQQQQSNGRQ-VGQVSSASSAGGAAGSSSSVAAAA- 343
            .   :|.......|..|||.   .|...|.:.|..|.|. :|.::..:|.|.....:|.::...
Human   309 L---KALGIVPNLPCTDNVA---FDMERLTRTQAVNRRSALGDLAGDNSLGLEPLRTSGISPLPQ 367

  Fly   344 ------------VAGTTRHGTFRR--------GHAGRNPFEESQSSDDENALLASTVRPATSS 386
                        :|.|::.|...|        ||:|  |..||:.|.          :|||.:
Human   368 DGELTPRTGEINIAVTSKWGPPLRHRACGCLCGHSG--PSGESRHSP----------QPATQT 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gzl	NP_001097695.1	PA_C_RZF_like	14..171	CDD:239038	32/120 (27%)
gzl	NP_001097695.1	zf-RING_2	233..277	CDD:290367	19/43 (44%)
RNF130	XP_024301897.1	PA_GRAIL_like	40..179	CDD:239037	35/126 (28%)
		zf-rbx1	<197..>306	CDD:331150	35/111 (32%)
		RING_Ubox	262..310	CDD:327409	21/51 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1487241at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920