DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gzl and Znrf3

DIOPT Version :9

Sequence 1:	NP_001097695.1	Gene:	gzl / 40791	FlyBaseID:	FBgn0037442	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_001074393.1	Gene:	Znrf3 / 407821	MGIID:	3039616	Length:	913	Species:	Mus musculus

Alignment Length:	507	Identity:	110/507 - (21%)
Similarity:	181/507 - (35%)	Gaps:	135/507 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 VYVVPARRPYYGCDSLDRPPHLKYPPSAKFVALVARGECVFERKIRVAQNASYSAVIVYNNEGDD 124
            |.||...:|     .||..|.|.....||                |..|..:.:.:...:...:.
Mouse   118 VGVVKLEQP-----ELDPKPCLTVLGKAK----------------RAVQRGATAVIFDVSENPEA 161

  Fly   125 LEQMSAENITGIRIPSVFV-GHTTGKALATYFTTEVVLIINDELPFNINTQ-----LILPFSILI 183
            ::|::..:...::.|.|:| |....|.:......:|.......||....|:     :.|.|.:::
Mouse   162 IDQLNQGSEDPLKRPVVYVKGADAIKLMNIVNKQKVARARIQHLPPRQPTEYFDMGIFLAFFVVV 226

  Fly   184 GMCFIIMVIYMIYKCIREQRRLRRHRLPKSMLKKLPVLRYTKNNANNK------YDT-------- 234
            .:..:|:::.:..|..|.|..:  :||....|:|:...::...:...:      .||
Mouse   227 SLVCLILLVKIKLKQRRSQNSM--NRLAVQALEKMETRKFNSKSKGRREGSCGALDTLSSGSTSD 289

  Fly   235 CVICLEDFIEDDKLRVLPCSHPYHTHCIDPWLTENRRVCPICKRKVF-TKGEARA--------SR 290
            |.||||.:|:.::|||:||:|.:|..|:||||.:: ..||.|:..:. .||...|        :|
Mouse   290 CAICLEKYIDGEELRVIPCTHRFHRKCVDPWLLQH-HTCPHCRHNIIEQKGNPGAVCVETSNLTR 353

  Fly   291 SRQPSLDNVTDTDDDTTPLLQQQQSNGRQVGQVSSASSAGGAAGSSSSVAAAAVAGTTRHG---- 351
            .|||.:         |.|:    ...|| |.:.::..:........|......:....|||
Mouse   354 GRQPRV---------TLPV----HYPGR-VHRTNAIPAYPTRTSMDSHGNPVTLLTMDRHGEQNL 404

  Fly   352 ------TFRRGHAGRNPFEESQSSDDENALLASTVRPATSSGAHERINPFDRAPNLPAHLAEQLT 410
                  |:.||:.   |..           |..|:.|...|..|...:        |||...:..
Mouse   405 YSPQTPTYVRGYP---PLH-----------LDHTLAPHRCSLEHRAYS--------PAHPFRRPK 447

  Fly   411 ESRRSVWSRINFASF-------------FRRQ-----PAVI----SVAAPPYLERVESGTSAMGL 453
            .|.||......|:.:             :..|     |:|.    |.|.||      ||.|::..
Mouse   448 FSSRSFSKAACFSQYETMYQHYYFQGLSYPEQEGQTIPSVTPRGQSRAFPP------SGASSLLF 506

  Fly   454 PVTGTIAVASPASNNILNPNLSGSFKDEDDMPPHRSIYEPIAISTPAADSAT 505
            |.  .:.||.|....      |||.........|||:........|.:||::
Mouse   507 PT--MVHVAPPTHVE------SGSTSSFSCYHGHRSVCSGYLADCPGSDSSS 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gzl	NP_001097695.1	PA_C_RZF_like	14..171	CDD:239038	21/111 (19%)
gzl	NP_001097695.1	zf-RING_2	233..277	CDD:290367	22/51 (43%)
Znrf3	NP_001074393.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32
		zf-RING_2	289..331	CDD:290367	20/42 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	601..669
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	855..913
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1487241at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920