DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gzl and Rnf167

DIOPT Version :9

Sequence 1:	NP_001097695.1	Gene:	gzl / 40791	FlyBaseID:	FBgn0037442	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_001008362.1	Gene:	Rnf167 / 360554	RGDID:	1305972	Length:	349	Species:	Rattus norvegicus

Alignment Length:	335	Identity:	113/335 - (33%)
Similarity:	176/335 - (52%)	Gaps:	34/335 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 KATSQ--LIEEFNDLPAQFGPNLPSNGLKVYVVPARRPYYGCDSLDRPPHLKYPPSAKFVALVAR 95
            :|||:  ...:|.||||.||..|...||:.::|.| .|...|..:..||......|. |:||:.|
  Rat    27 RATSEHNASMDFADLPALFGATLSDEGLQGFLVEA-HPENACSPIAPPPSAPVNGSV-FIALLRR 89

  Fly    96 GECVFERKIRVAQNASYSAVIVYNNEGDDLEQM---SAENITGIRIPSVFVGHTTGKALATYFTT 157
            .:|.|:.|:..||.|.|.|.:|:|...::|..|   |.|....|.|||||:|..:.:.|...|..
  Rat    90 FDCNFDLKVLNAQKAGYGAAVVHNVNSNELLNMVWNSEEIQQQIWIPSVFIGERSAEYLRALFVY 154

  Fly   158 E----VVLIINDELPFNINTQLILPFSILIGMCFIIMVIYMIYKCIREQRRLRRHRLPKSMLKKL 218
            |    |:|:.::..|..   ..::||:.::|:..:.|...:|.:||:.::||:|:||.|..||::
  Rat   155 EKGARVLLVPDNSFPLG---YYLIPFTGIVGLLVLAMGTVLIVRCIQHRKRLQRNRLTKEQLKQI 216

  Fly   219 PVLRYTKNNANNKYDTCVICLEDFIEDDKLRVLPCSHPYHTHCIDPWLTENRRVCPICKRKVF-- 281
            |...|.|   .::||.|.|||:::.:.||||:|||:|.||:.|:|||||:.|:.|||||:.|.
  Rat   217 PTHDYQK---GDEYDVCAICLDEYEDGDKLRILPCAHAYHSRCVDPWLTQTRKTCPICKQPVHRG 278

  Fly   282 ---------TKGEARASRSRQPSLDNVTDTDDDTTPLLQQQQSNGRQVGQVSSASSA--GGAAGS 335
                     |:|:.......:|.    .....:.||||....:.....|.::.|...  |.:...
  Rat   279 PGDEEQEEETQGQEEEGDEGEPR----DQPASEWTPLLGSSPTLPTSFGSLAPAPLVFPGPSTDP 339

  Fly   336 SSSVAAAAVA 345
            |.|.::||:|
  Rat   340 SPSPSSAALA 349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gzl	NP_001097695.1	PA_C_RZF_like	14..171	CDD:239038	51/146 (35%)
gzl	NP_001097695.1	zf-RING_2	233..277	CDD:290367	25/43 (58%)
Rnf167	NP_001008362.1	PA_C_RZF_like	20..170	CDD:239038	50/144 (35%)
		RING-H2_RNF167	228..273	CDD:319711	26/44 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	271..349		17/81 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	76	1.000	Domainoid score	I8729
eggNOG	1	0.900	-	-		E1_KOG4628
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	210	1.000	Inparanoid score	I3584
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1487241at2759
OrthoFinder	1	1.000	-	-		FOG0001489
OrthoInspector	1	1.000	-	-		otm45328
orthoMCL	1	0.900	-	-		OOG6_103040
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X670
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.730