DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gzl and Rnf13

DIOPT Version :9

Sequence 1:	NP_001097695.1	Gene:	gzl / 40791	FlyBaseID:	FBgn0037442	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_001106884.1	Gene:	Rnf13 / 24017	MGIID:	1346341	Length:	381	Species:	Mus musculus

Alignment Length:	375	Identity:	135/375 - (36%)
Similarity:	203/375 - (54%)	Gaps:	50/375 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 QILTLLGLCLVCHEATL-VGGHVLVYRKATSQLIEEFNDLPAQFGPNLPSNGLKVYVVPARRPYY 70
            |:.|:|.:.|......| |...:|.|....:.  :.|.||||:||..||:.|||.:::.: :|..
Mouse    14 QVYTILTVQLFAFLNLLPVEADILAYNFENAS--QTFEDLPARFGYRLPAEGLKGFLINS-KPEN 75

  Fly    71 GCDSLDRPPHLKYPPSAKFVALVARGECVFERKIRVAQNASYSAVIVYNNEGDDLEQMSAENITG 135
            .|:.: .||.||...|..|:.|:.|.:|.|:.|:..||.|.|.|.||:|.:.|||..|.:.:|..
Mouse    76 ACEPI-VPPPLKDNSSGTFIVLIRRLDCNFDIKVLNAQRAGYKAAIVHNVDSDDLISMGSNDIDT 139

  Fly   136 IR---IPSVFVGHTTGKALATYFTTE----VVLIINDELPFNINTQLILPFSILIGMCFIIMVIY 193
            ::   |||||:|.::..:|...||.|    ::|:....||..   ..::||.|::|:|.|::||:
Mouse   140 LKKIDIPSVFIGESSANSLKDEFTYEKGGHIILVPELSLPLE---YYLIPFLIIVGICLILIVIF 201

  Fly   194 MIYKCIREQRRLRRHRLPKSMLKKLPVLRYTKNNANNKYDTCVICLEDFIEDDKLRVLPCSHPYH 258
            ||.|.::::.|.||:||.|..||||||.::.|   .::||.|.||||::.:.||||:|||||.||
Mouse   202 MITKFVQDRHRNRRNRLRKDQLKKLPVHKFKK---GDEYDVCAICLEEYEDGDKLRILPCSHAYH 263

  Fly   259 THCIDPWLTENRRVCPICKRKVFTKGEARASRSRQPSLDNVTDTDDDTTPLLQQQQSNGRQVGQV 323
            ..|:|||||:.::.||:||:||.            ||..   |:|.||.   ..|:.|     ||
Mouse   264 CKCVDPWLTKTKKTCPVCKQKVV------------PSQG---DSDSDTD---SSQEEN-----QV 305

  Fly   324 SSASSAGGAAGSSSSVAAAAVAGTTRHGTFRRGHAGRNPFEESQSSDDEN 373
            |.         .:..:..:|.|.|...|:....|:..|..|.|...||:|
Mouse   306 SE---------HTPLLPPSASARTQSFGSLSESHSHHNMTESSDYEDDDN 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gzl	NP_001097695.1	PA_C_RZF_like	14..171	CDD:239038	56/164 (34%)
gzl	NP_001097695.1	zf-RING_2	233..277	CDD:290367	25/43 (58%)
Rnf13	NP_001106884.1	PA_C_RZF_like	23..180	CDD:239038	55/160 (34%)
		RING-H2_RNF167	238..283	CDD:319711	26/44 (59%)
		RING-H2 finger (C3H2C3-type)	240..281	CDD:319711	24/40 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	285..381		23/94 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	77	1.000	Domainoid score	I8834
eggNOG	1	0.900	-	-		E1_KOG4628
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	213	1.000	Inparanoid score	I3624
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1487241at2759
OrthoFinder	1	1.000	-	-		FOG0001489
OrthoInspector	1	1.000	-	-		otm43256
orthoMCL	1	0.900	-	-		OOG6_103040
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1776
SonicParanoid	1	1.000	-	-		X670
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.760