DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gzl and RNF133

DIOPT Version :9

Sequence 1:	NP_001097695.1	Gene:	gzl / 40791	FlyBaseID:	FBgn0037442	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_631914.1	Gene:	RNF133 / 168433	HGNCID:	21154	Length:	376	Species:	Homo sapiens

Alignment Length:	395	Identity:	101/395 - (25%)
Similarity:	153/395 - (38%)	Gaps:	102/395 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 VGGHVLVYRKATSQLIEEFNDLPAQFGPNLPSNGLK----VYVVPARRPYYGCDSLDRPPHLKYP 84
            ||.|||      |:|.|     ...||   .|:.||    |.|.|..:....|:........||
Human    48 VGNHVL------SELGE-----TGVFG---RSSTLKRVAGVIVPPEGKIQNACNPNTIFSRSKY- 97

  Fly    85 PSAKFVALVARGECVFERKIRVAQNASYSAVIVYNNEG-------------DDLEQMSAENITGI 136
             |..::||:.||.|.|.:||:||.....|.||:||..|             :|:..:...|:.|.
Human    98 -SETWLALIERGGCTFTQKIKVATEKGASGVIIYNVPGTGNQVFPMFHQAFEDVVVVMIGNLKGT 161

  Fly   137 RIPSVFVGHTTGKALATYFTTEV----VLIINDELPFNINTQLILPFSILIGMCFIIMVIYMIYK 197
            .|     .|...|.:......||    ::.:|         ..::.|.|:........:.|.|::
Human   162 EI-----FHLIKKGVLITAVVEVGRKHIIWMN---------HYLVSFVIVTTATLAYFIFYHIHR 212

  Fly   198 -CIREQRRLRRHRLPKSMLK-----KLPVLRYTKNNANNKYDTCVICLEDFIEDDKLRVLPCSHP 256
             |:...:..|..||...:..     :|.|::......|...|:||||.|.:..:|.:|:|.|.|.
Human   213 LCLARIQNRRWQRLTTDLQNTFGQLQLRVVKEGDEEINPNGDSCVICFERYKPNDIVRILTCKHF 277

  Fly   257 YHTHCIDPWLTENRRVCPICK---RKVFTKGEARASRSRQPSLDNVTDTDDDTTPLLQQQQSNGR 318
            :|.:|||||:..: ..|||||   .||.         ..|..::|.|:.       ||...||
Human   278 FHKNCIDPWILPH-GTCPICKCDILKVL---------GIQVVVENGTEP-------LQVLMSN-- 323

  Fly   319 QVGQVSSAS-----SAGGAAGSSSSVAAAAVAGTTRHGTFRRGHAGRNPFEESQSSDDENALLAS 378
            ::.:..|.|     :....||:|..|.                |...||  .||::|.:...:..
Human   324 ELPETLSPSEEETNNEVSPAGTSDKVI----------------HVEENP--TSQNNDIQPHSVVE 370

  Fly   379 TVRPA 383
            .|.|:
Human   371 DVHPS 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gzl	NP_001097695.1	PA_C_RZF_like	14..171	CDD:239038	45/167 (27%)
gzl	NP_001097695.1	zf-RING_2	233..277	CDD:290367	20/43 (47%)
RNF133	NP_631914.1	PA_GRAIL_like	43..177	CDD:239037	42/149 (28%)
		RING_Ubox	254..302	CDD:327409	22/48 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	327..376		14/67 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4628
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1487241at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820