DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gzl and rnf167

DIOPT Version :9

Sequence 1:	NP_001097695.1	Gene:	gzl / 40791	FlyBaseID:	FBgn0037442	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	XP_005165694.2	Gene:	rnf167 / 101055497	ZFINID:	ZDB-GENE-110126-2	Length:	401	Species:	Danio rerio

Alignment Length:	412	Identity:	133/412 - (32%)
Similarity:	210/412 - (50%)	Gaps:	57/412 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LCLVCHEATLV--GGHVLVYRKATSQLIEEFNDLPAQFGPNLPSNGLKVYVVPARRPYYGCDSLD 76
            |.:.|   |||  .|...:|...::.....|.||||.||..||.:||...::.| ||...|..:|
Zfish    14 LIIFC---TLVPSPGQAYIYAHYSNMTSMLFEDLPALFGSALPKDGLMGVLIEA-RPQNACTPID 74

  Fly    77 RPPHLKYP----PSAKFVALVARGECVFERKIRVAQNASYSAVIVYNNEGDDLEQMSAENIT--- 134
            .||....|    .:.|::.|:.|.:|.|:.|:..||.|.|||.||:|...:.|..|...|.|
Zfish    75 PPPASPTPADPNSTTKYIVLIRRYDCNFDVKVYHAQQAGYSAAIVHNMYSNSLLNMGYSNETIAE 139

  Fly   135 GIRIPSVFVGHTTGKALATYFTTEVV----------LIINDELPFNINTQLILPFSILIGMCFII 189
            .|.|||||         .::|.::::          :::..|..|.::..|| ||:.::.|..|:
Zfish   140 EISIPSVF---------TSFFASQMLHKIIPEKGAYVVLKPEFSFPLSYYLI-PFTGVVCMIIIV 194

  Fly   190 MVIYMIYKCIREQRRLRRHRLPKSMLKKLPVLRYTKNNANNKYDTCVICLEDFIEDDKLRVLPCS 254
            |||.||.:|::.::|||::||.|..|||:|:.::.|.::   ||.|.|||:::.|.|||||||||
Zfish   195 MVIIMIVRCVQHRKRLRKNRLSKEQLKKIPIHKFNKGDS---YDVCAICLDEYEEGDKLRVLPCS 256

  Fly   255 HPYHTHCIDPWLTENRRVCPICKRKVFTKGE--ARASRSRQPSLDNVTDTDDDTTPLLQQQQSNG 317
            |.||:.|:|||||:.::.||:||::|.....  :.:|.|.:.:..:..:.:|:.||||:.....
Zfish   257 HAYHSRCVDPWLTQTKKTCPVCKQRVTRPNPEYSESSDSDEEAGPHDAEEEDERTPLLRPSNPG- 320

  Fly   318 RQVGQVSSASSAGGAAGSSS--------SVAAAAVAGTTRH-GTFRRGHAGRNPFEESQ---SSD 370
                  |.|||:...:.||:        :.||..:..|.:| ..........:|.|:|.   |.|
Zfish   321 ------SPASSSPPPSYSSTVASEPATVTTAAQCLPHTPQHDAPLLANDEYYSPIEDSDDEGSED 379

  Fly   371 DENALLASTVRPATSSGAHERI 392
            :|....:.:.......||..|:
Zfish   380 EEEGHASESDTTELIGGAAVRV 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gzl	NP_001097695.1	PA_C_RZF_like	14..171	CDD:239038	54/175 (31%)
gzl	NP_001097695.1	zf-RING_2	233..277	CDD:290367	26/43 (60%)
rnf167	XP_005165694.2	PA_C_RZF_like	14..177	CDD:239038	54/175 (31%)
		RING-H2_RNF167	235..280	CDD:319711	27/44 (61%)
		RING-H2 finger (C3H2C3-type)	237..278	CDD:319711	25/40 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	77	1.000	Domainoid score	I8792
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	209	1.000	Inparanoid score	I3657
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1487241at2759
OrthoFinder	1	1.000	-	-		FOG0001489
OrthoInspector	1	1.000	-	-		otm25895
orthoMCL	1	0.900	-	-		OOG6_103040
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X670
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.870