DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gzl and rnf43

DIOPT Version :9

Sequence 1:	NP_001097695.1	Gene:	gzl / 40791	FlyBaseID:	FBgn0037442	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	XP_002935238.2	Gene:	rnf43 / 100491274	XenbaseID:	XB-GENE-952685	Length:	689	Species:	Xenopus tropicalis

Alignment Length:	544	Identity:	107/544 - (19%)
Similarity:	178/544 - (32%)	Gaps:	191/544 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 KIRVA-QNASYSAVIVYNNEGDDLEQMSAENITGIRIPSVFVGHTTGKALATYFTTEVVLIINDE 166
            |.|:| :..:::.:....|:...|:|:  :...||..|.|.:.....:.|..      |:..|.|
Frog   119 KARLAGERGAHAVLFDITNDRGALQQL--QQPAGINQPVVLIWGPDAEKLMD------VVNKNKE 175

  Fly   167 LPFNINTQ-----LILPFSILIGMCFIIM--VIYMIYKCIREQRRLRRHRLPKSMLKKLPVL--- 221
            ....|..|     |.....||:.:...:|  |:|.:      .|.|.|...|:..:::..:|
Frog   176 ALVKIEVQEQPKWLHHDIWILLTVAGTVMFFVLYAV------ARLLCRQPPPQDSIQQQTLLAIS 234

  Fly   222 -----RYTKN---------------NANNKYDTCVICLEDFIEDDKLRVLPCSHPYHTHCIDPWL 266
                 ||.:.               :.::....|.||||:|.:..:||:|||.|.||..|:||||
Frog   235 RLGTRRYQQRMLKDQRASGGWVETASTSSSVPVCAICLEEFTDGQELRILPCCHEYHLGCVDPWL 299

  Fly   267 TENRRVCPICKRKVFTKG-EARASRSRQPSLDN-----------VTDTDDDTTPLLQQQQSNG-- 317
            .:| ..||:|...:...| ..|....|.||...           ::......||::....:|.
Frog   300 RQN-HTCPLCMYDILDSGTPPRPLAHRAPSQTQLWGRYPGSARLMSHLPPHGTPMVFPTPNNSLF 363

  Fly   318 ----------------------------------RQVG-----QVSS--------ASSAGGAAGS 335
                                              |::|     |.||        :.|:.|....
Frog   364 LPRAPYYLDHTHHWQMPEQMAMQMRTHRRGAEGTRELGISPGCQDSSGYLPDDPGSDSSSGPCHG 428

  Fly   336 SSSVAAAAVAGTTRHGTFRRGHAGRNPFEESQSSDDENA--LLASTVRPATSSGAHERINPFDRA 398
            |||.....::....|||      ..:....|||:.::::  .|||.:.|   .|....:||
Frog   429 SSSENCTDISLHCLHGT------SSSSVHSSQSNQEDSSPPALASYLLP---QGELPALNP---- 480

  Fly   399 PNLPAHLAEQLTESRRSVWSRINFAS-----FFRRQPAV-------------ISVAAPPYLERVE 445
                      |..::.|..|.::|..     :.|.||::             :|.|.|.|.....
Frog   481 ----------LLSTQASYASHVHFHQHRHHHYRRNQPSMSHSHPHRSKRRTKVSRADPSYYREHR 535

  Fly   446 SGTSAMG----------------------------------LPVTGTIAVASPASNNILNPNLSG 476
            ..|.|.|                                  :|...::...|.      .|:::.
Frog   536 HTTGANGELRSLMVRREPRPSCSRTCFDPRTNREHPRHQQSMPQAASVVQGSS------EPDVAT 594

  Fly   477 SFKDEDDMPPHRSIYEPIAISTPA 500
            |.:.....||.|: |.....|.|:
Frog   595 SLRGSRTDPPSRT-YRKKKSSAPS 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gzl	NP_001097695.1	PA_C_RZF_like	14..171	CDD:239038	14/68 (21%)
gzl	NP_001097695.1	zf-RING_2	233..277	CDD:290367	22/43 (51%)
rnf43	XP_002935238.2	ZNRF_3_ecto	80..182	CDD:375639	15/70 (21%)
		HRD1	<244..366	CDD:227568	31/122 (25%)
		RING-H2_RNF43_like	267..311	CDD:319580	23/44 (52%)
		RING-H2 finger (C3H2C3-type)	268..308	CDD:319580	22/40 (55%)
		DUF4573	523..643	CDD:373595	17/102 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1487241at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920