Protein Alignment TfIIFalpha and TFG1

DIOPT Version :10

• Sequence 1: NP_524246.1
• Gene: TfIIFalpha / 40790
• FlyBaseID: FBgn0010282
• Length: 577
• Species: Drosophila melanogaster
• Sequence 2: NP_011702.1
• Gene: TFG1 / 853098
• SGDID: S000003418
• Length: 735
• Species: Saccharomyces cerevisiae
• Alignment Length: 608
• Identity: 134/608 - (22%)
• Similarity: 241/608 - (39%)
• Gaps: 166/608 - (27%)

  Fly     4 ASKSTPSAASGSSTSAAAAAAASVASGSASSSANVQEFKIRVPKM--------PKKHHVMRFNAT 60
            ||.:|.||...:..|..:.:||:...|:| |:||:...:..|.|:        |.|..::::
Yeast   230 ASPTTVSAVESNGLSNGSTSAANGLDGNA-STANLANGRPLVTKLEDAGPAEDPTKVGMVKY--- 290

  Fly    61 LNVDFAQWRNVKLERENNMKEFRGMEEDQPKFGAGSEYNRDQREEARRK--KFGII---ARKYR- 119
               |..:..|.....|..|.....:..|    |.|    |.:|...|||  :..::   |:|.|
Yeast   291 ---DGKEVTNEPEFEEGTMDPLADVAPD----GGG----RAKRGNLRRKTRQLKVLDENAKKLRF 344

  Fly   120 PEAQPWILKVGGKTGKKFKG----IREGGVGENAAFYVFTHAPDGAIEAYPLTEWYNFQPIQRYK 180
            .|..||::       :.|.|    :.....|.:.::.:.:...||:....|..:.|.|....:|.
Yeast   345 EEFYPWVM-------EDFDGYNTWVGSYEAGNSDSYVLLSVEDDGSFTMIPADKVYKFTARNKYA 402

  Fly   181 SLSAEEAEQEFGRR-----KKVMNYFSLM---------LRKRLRG-------DEEEEQDPEEAKL 224
            :|:.:|||:...::     :.:|.:...:         .|::|:.       ||::..|..|.:|
Yeast   403 TLTIDEAEKRMDKKSGEVPRWLMKHLDNIGTTTTRYDRTRRKLKAVADQQAMDEDDRDDNSEVEL 467

  Fly   225 IKAATKKSKELKITDMDEWIDSEDES---DSEDEEDKKKKEQEDSDDGKAKGKGKKGADKKKKKR 286
                          |.||....::|:   |..::|:|:.:::...:..:|...|.:
Yeast   468 --------------DYDEEFADDEEAPIIDGNEQENKESEQRIKKEMLQANAMGLR--------- 509

  Fly   287 DVDDEAFEESDDGDEEGREMDYDTSSSEDEPDPEAKVDKD---MKGVAEEDALRKLLTSDEEEDD 348
              |:||..|::                |||...|.|:|:|   :|...::..|..|.:|||.|.:
Yeast   510 --DEEAPSENE----------------EDELFGEKKIDEDGERIKKALQKTELAALYSSDENEIN 556

  Fly   349 EKKSDESDKEDADGEKK-KKDKGKDEVSKDKKKKKPTKDDKKGKSNGSGDSSTDFSSDSTDSEDD 412
            ...| |||.|:.:.|.. ||::..|.:|| .|:..|.|..||.            ::.....|..
Yeast   557 PYLS-ESDIENKENESPVKKEEDSDTLSK-SKRSSPKKQQKKA------------TNAHVHKEPT 607

  Fly   413 LSNGPPKKKVVVKDKDKEKEK---EKE-SAASSKVIASSSNANKSRSATPTLSTDASKRKMNSLP 473
            |.....|..|::...||:..|   |.| :..::|.:.||:||:                  |::|
Yeast   608 LRVKSIKNCVIILKGDKKILKSFPEGEWNPQTTKAVDSSNNAS------------------NTVP 654

  Fly   474 SDLTASDTSNSPTSTPAKRPKNEISTSLPTSFSGGKVEDYGITEEAVRRYLKRKPLTATELLTKF 538
            |.:...:..|   ||.|:|.:    |..||......:|..|..:..::.:            .||
Yeast   655 SPIKQEEGLN---STVAEREE----TPAPTITEKDIIEAIGDGKVNIKEF------------GKF 700

  Fly   539 KNKKTPVSSDRLVETMTKILKKI 561
            ..:|.|.:.::  :.|..|:||:
Yeast   701 IRRKYPGAENK--KLMFAIVKKL 721

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TfIIFalpha	NP_524246.1	TFIIF_alpha	37..577	CDD:310411	122/575 (21%)
TFG1	NP_011702.1	PRK10856	<160..>287	CDD:236776	17/57 (30%)
		TFIIF_alpha	318..>580	CDD:310411	68/314 (22%)