DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TfIIFalpha and GTF2F1

DIOPT Version :9

Sequence 1:	NP_524246.1	Gene:	TfIIFalpha / 40790	FlyBaseID:	FBgn0010282	Length:	577	Species:	Drosophila melanogaster
Sequence 2:	XP_024307243.1	Gene:	GTF2F1 / 2962	HGNCID:	4652	Length:	542	Species:	Homo sapiens

Alignment Length:	598	Identity:	232/598 - (38%)
Similarity:	341/598 - (57%)	Gaps:	117/598 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 SSANVQEFKIRVPK-MPKKHHVMRFNATLNVDFAQWRNVKLERE-NNMKEFRGMEEDQPKFGAGS 96
            ||.||.|:.:|||| ..||:::|.|||...|:||.|...:|||: :|.|.::  ||:.|:.||||
Human     7 SSQNVTEYVVRVPKNTTKKYNIMAFNAADKVNFATWNQARLERDLSNKKIYQ--EEEMPESGAGS 69

  Fly    97 EYNRDQREEARRKKFGIIARKYRPEAQPWILKVGGKTGKKFKGIREGGVGENAAFYVFTHAPDGA 161
            |:||..||||||||:||:.:::|||.|||:|:|.||:|:|||||::|||.||.::|:||..||||
Human    70 EFNRKLREEARRKKYGIVLKEFRPEDQPWLLRVNGKSGRKFKGIKKGGVTENTSYYIFTQCPDGA 134

  Fly   162 IEAYPLTEWYNFQPIQRYKSLSAEEAEQEFGRRKKVMNYFSLMLRKRLRGDEEEEQDPEEAKLIK 226
            .||:|:..||||.|:.|:::|:|||||:|:.||.||:|:||:|.::||: |:::::|.||.:  |
Human   135 FEAFPVHNWYNFTPLARHRTLTAEEAEEEWERRNKVLNHFSIMQQRRLK-DQDQDEDEEEKE--K 196

  Fly   227 AATKKSKELKITDMDEWID-SEDESDSEDEEDKKKKEQEDSDDGKAKGKG--KKGADKKKKKRDV 288
            ...:|:.||:|.|:::.:: |.|.||:..||..:..        |||.|.  .||..|||||:..
Human   197 RGRRKASELRIHDLEDDLEMSSDASDASGEEGGRVP--------KAKKKAPLAKGGRKKKKKKGS 253

  Fly   289 DDEAFEESDDGDEEGREMDY---DTSSSEDEPDPEAKVDKD------------------------ 326
            ||||||:|||||.||:|:||   .:|||::||:.:||..:.
Human   254 DDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPESKAKAPQQEEGPKGRRWLGGPGRWGRCFPALA 318

  Fly   327 ----MKGVAEEDALRKLLTSDEEEDDEKKSDESDKEDADGEKKKKDKGKDEVSKDKKKKKPTKDD 387
                :.||.|:       :...||.:|:|..|.|||:                 :::||.||..:
Human   319 HTLPLPGVDEQ-------SDSSEESEEEKPPEEDKEE-----------------EEEKKAPTPQE 359

  Fly   388 KKGKSNGSGDSSTDFSSDSTDSEDDLSNGPPKKKVVVKDKDKEKEKEKESAASSKVIASSSNANK 452
            ||.:.:.|.:|.   ||:.:|.:.:.|:.    ..:.|.|...|.:.|.|..||:        ..
Human   360 KKRRKDSSEESD---SSEESDIDSEASSA----LFMAKKKTPPKRERKPSGGSSR--------GN 409

  Fly   453 SRSATP---------TLSTDASKRKMNSLPSDLTAS-----DTSNSPTSTPAKRPKNEISTSLPT 503
            ||..||         ||...|||.:.....|::.|:     ||  .|.|...|      ||..|.
Human   410 SRPGTPSAEGGSTSSTLRAAASKLEQGKRVSEMPAAKRLRLDT--GPQSLSGK------STPQPP 466

  Fly   504 SFSGGKVE----DYGITEEAVRRYLKRKPLTATELLTKFKNKKTPVSSDRLVETMTKILKKINPV 564
            |   ||..    |..:||:||||||.|||:|..:||.||:.|||.:||::.|..:.:|||::||.
Human   467 S---GKTTPNSGDVQVTEDAVRRYLTRKPMTTKDLLKKFQTKKTGLSSEQTVNVLAQILKRLNPE 528

  Fly   565 KHTIQGKMYLWIK 577
            :..|..||:..:|
Human   529 RKMINDKMHFSLK 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TfIIFalpha	NP_524246.1	TFIIF_alpha	37..577	CDD:253391	229/593 (39%)
TfIIFalpha	NP_524246.1	TFIIFa	39..199	CDD:238147	88/161 (55%)
GTF2F1	XP_024307243.1	TFIIF_alpha	2..542	CDD:310411	232/598 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148026
Domainoid	1	1.000	375	1.000	Domainoid score	I879
eggNOG	1	0.900	-	-		E1_KOG2393
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	375	1.000	Inparanoid score	I2110
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55429
OrthoDB	1	1.010	-	-		D382179at33208
OrthoFinder	1	1.000	-	-		FOG0007367
OrthoInspector	1	1.000	-	-		oto90522
orthoMCL	1	0.900	-	-		OOG6_106717
Panther	1	1.100	-	-	LDO	PTHR13011
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3664
SonicParanoid	1	1.000	-	-		X6255
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800