Protein Alignment TfIIFalpha and gtf-2F1

DIOPT Version :10

• Sequence 1: NP_524246.1
• Gene: TfIIFalpha / 40790
• FlyBaseID: FBgn0010282
• Length: 577
• Species: Drosophila melanogaster
• Sequence 2: NP_494756.1
• Gene: gtf-2F1 / 173764
• WormBaseID: WBGene00015296
• Length: 481
• Species: Caenorhabditis elegans
• Alignment Length: 556
• Identity: 186/556 - (33%)
• Similarity: 259/556 - (46%)
• Gaps: 126/556 - (22%)

  Fly    40 EFKIRVPKMPK--KHHVMRFNATLNVDFAQW---RNVKLERENNMKEFRGMEEDQPKFGAGSEYN 99
            ||.:||.|...  ::.||.||....||.::|   ..|.:|||:|.:.....:..| ::|.||||.
 Worm    15 EFSVRVAKRSDDIRYSVMMFNGMDKVDTSKWTIDSGVTMEREDNQRVILSTQTVQ-EYGEGSEYG 78

  Fly   100 RDQREEARRKKFGIIARKYRPEAQPWILKVGGKTG--KKFKGIREGGVGENAAFYVFTHAPDGAI 162
            :..||||||||:|..::|||.:.|||.:......|  ::.:||||||..|:|.::||. .|:.:.
 Worm    79 KAAREEARRKKYGRQSKKYRLDNQPWKMAFTEPEGRQRQMRGIREGGANEHADYWVFL-KPNQSS 142

  Fly   163 E--AYPLTEWYNFQPIQRYKSLSAEEAEQEFGRRKKVMNYFSL--MLRKRLRGDEEEEQDPEEAK 223
            |  ||.:.||:.|.|...:|:|..::||::|.:|.||||.|:|  .::.:|...:|.|...::.:
 Worm   143 EFKAYKVDEWHKFLPAITHKTLDIDQAEEQFSQRYKVMNQFALKAAIQNQLSATDESEMTEQQKR 207

  Fly   224 LIKAATKKSKELKITDMDEWIDSEDESDSEDEEDKKKKEQEDSDDGKA---KGKGKKGADKKKKK 285
            |:|                 |..|..||..|.:|    |.|..||||.   |.|.||.|...|:|
 Worm   208 LLK-----------------IKDEASSDDSDGDD----EGEGGDDGKKAKNKKKKKKNAKPAKEK 251

  Fly   286 R----DVDDEAFEESDDGDEEGREMDY----DTSSSEDEPDPEAKVDKDMKGVAEEDALRKLLTS 342
            |    |.||.|..||.||::||||.||    .|.|..::...:.|::|.:.|||||:..|
 Worm   252 RQRVEDKDDVAKYESSDGEDEGREYDYISDSGTDSDREQVPSDEKIEKQLVGVAEEEGAR----- 311

  Fly   343 DEEEDDEKKSDESDKEDADGEKKKKDKGKDEVSKDKKKKKPTKDDKKGKSNGSGDSSTDFSSDST 407
                    :||.|:.||               ...||..||..|.|||......|||      .|
 Worm   312 --------ESDSSESED---------------DLTKKLMKPYGDKKKGNDIEERDSS------GT 347

  Fly   408 DSEDDLSNGPPKKKVVVKDKDKEKEKEKESAASSKVIASSSNANKSRSATPTLSTDASKRKMNSL 472
            ||  |:|:......||....:|:.|            ..|....|.|  .||..:|.   ||::|
 Worm   348 DS--DVSDTEKLDSVVFMKANKDGE------------GGSGGTGKKR--PPTEDSDL---KMDNL 393

  Fly   473 -PSDLTASDTSNSPTSTPAKRPKNEISTSLPTSFSGGKVEDYGITEEAVRRYLKRKPLTATELLT 536
             |||              ||:.|..:           |.|: |:.||.|||||:|||.|..|||.
 Worm   394 GPSD--------------AKKAKPAV-----------KFEE-GLNEETVRRYLRRKPHTTKELLH 432

  Fly   537 KFKNKKTPVSSDRLVETMTKILKKINP-VKHTIQGK 571
            |...|...:|...:|..:..|||.|.| ....::||
 Worm   433 KMNGKCGNMSKSEMVTQLASILKAIEPNQSRQLKGK 468

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TfIIFalpha	NP_524246.1	TFIIF_alpha	37..577	CDD:310411	186/556 (33%)
gtf-2F1	NP_494756.1	TFIIF_alpha	2..474	CDD:310411	186/556 (33%)