DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TfIIFalpha and gtf2f1

DIOPT Version :9

Sequence 1:	NP_524246.1	Gene:	TfIIFalpha / 40790	FlyBaseID:	FBgn0010282	Length:	577	Species:	Drosophila melanogaster
Sequence 2:	NP_001116271.1	Gene:	gtf2f1 / 100124929	XenbaseID:	XB-GENE-974834	Length:	522	Species:	Xenopus tropicalis

Alignment Length:	579	Identity:	224/579 - (38%)
Similarity:	343/579 - (59%)	Gaps:	97/579 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 SSSANVQEFKIRVPKMP-KKHHVMRFNATLNVDFAQWRNVKLERENNMKEFRGMEEDQPKFGAGS 96
            :|..:|.|:.:|||:.| |::.:|.|||...|||:.|...::||:.:.|:.. .:|:.|:.||||
Frog     6 TSGQSVTEYVVRVPRNPNKRYSLMAFNAADKVDFSTWNQARMERDLSAKKMY-QDEEMPESGAGS 69

  Fly    97 EYNRDQREEARRKKFGIIARKYRPEAQPWILKVGGKTGKKFKGIREGGVGENAAFYVFTHAPDGA 161
            ||||.||||:||||:|||.::::.|.|||:|:|.||.|:|:||:::|||.|||::|:||...|||
Frog    70 EYNRKQREESRRKKYGIILKEFKLEDQPWLLRVNGKAGRKYKGVKKGGVTENASYYIFTQCADGA 134

  Fly   162 IEAYPLTEWYNFQPIQRYKSLSAEEAEQEFGRRKKVMNYFSLMLRKRLR----GDEEEEQDPEEA 222
            .||:|::.||||.|:.::::|:|||||||:.||.||:|:|::|.::||:    .|:|||...::.
Frog   135 FEAFPVSNWYNFTPLAKHRTLTAEEAEQEWERRNKVLNHFTIMQQRRLKDQVGDDDEEEGGGKQE 199

  Fly   223 KLIKAATKKSK-ELKITDMDEWID--SEDESDSEDEEDKKKKEQEDSDDGKAKGKGKKGADKKKK 284
            |..|...||.| :|||.|:::.:|  |.:..||::|.:::.|.|:     ||..||     ||||
Frog   200 KGGKGKKKKKKSDLKIHDLEDDLDMSSSESEDSDEEGERRTKPQK-----KAPAKG-----KKKK 254

  Fly   285 KRDVDDEAFEESDDGDEEGREMDY--DTSSSEDEPDPE---AKVDKDMKGVAEEDALRKLLTSDE 344
            |:..||||.|:|||||.||:|:||  |.|||::|...:   ||.::..||:.|:       :...
Frog   255 KQKSDDEALEDSDDGDFEGQEVDYMSDESSSDEELPGKIKPAKEEEGPKGLDEQ-------SESS 312

  Fly   345 EEDDEKKSDESDKED------ADGEKKKKDKGKD--EVSKD------------KKKKKPTKDDKK 389
            ||.:|:|::|.::|:      .|.:||||:...|  |.|:|            :|||.|:|.|||
Frog   313 EESEEEKAEEEEEEEKKAPTPQDNKKKKKEDSSDESETSEDSDIDGASSSLFMQKKKTPSKKDKK 377

  Fly   390 GKSNGSGDSSTDFSSDSTDSEDDLSNGPPKKKVVVKDKDKEKEKEKESAASSKVIASSSNANKSR 454
            |   ||..||...|...|.|.|                        ....||.:.|::|...:|:
Frog   378 G---GSNSSSRGNSRPGTPSPD------------------------TGNTSSTLRAAASKLEQSK 415

  Fly   455 SATPTLSTDASKR-KMNSLPSDLTASDTSNSPTSTPAKRPKNEISTSLPTSFSGGKVEDYGITEE 518
            ....: :|.|:|| ||.|.|.:.:...|           |:.:...|.|:|      .|..:||:
Frog   416 RGAVS-NTPAAKRLKMESGPQNTSGKST-----------PQPQSGKSTPSS------GDIQLTED 462

  Fly   519 AVRRYLKRKPLTATELLTKFKNKKTPVSSDRLVETMTKILKKINPVKHTIQGKMYLWIK 577
            ||||||.|||:|..:||.||:.|||.:||::.|..:.:|||::||.:..:..||:.::|
Frog   463 AVRRYLTRKPMTTKDLLKKFQTKKTGLSSEQTVNVLAQILKRLNPDRKVVHDKMHFYLK 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TfIIFalpha	NP_524246.1	TFIIF_alpha	37..577	CDD:253391	222/573 (39%)
TfIIFalpha	NP_524246.1	TFIIFa	39..199	CDD:238147	82/160 (51%)
gtf2f1	NP_001116271.1	TFIIF_alpha	2..522	CDD:310411	224/579 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	356	1.000	Domainoid score	I985
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	357	1.000	Inparanoid score	I2179
OMA	1	1.010	-	-		QHG55429
OrthoDB	1	1.010	-	-		D382179at33208
OrthoFinder	1	1.000	-	-		FOG0007367
OrthoInspector	1	1.000	-	-		oto104320
Panther	1	1.100	-	-	LDO	PTHR13011
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3664
SonicParanoid	1	1.000	-	-		X6255
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.110