DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CRAT and cpt-1

DIOPT Version :9

Sequence 1:	NP_001287195.1	Gene:	CRAT / 40787	FlyBaseID:	FBgn0037440	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_496721.2	Gene:	cpt-1 / 174912	WormBaseID:	WBGene00012907	Length:	779	Species:	Caenorhabditis elegans

Alignment Length:	706	Identity:	187/706 - (26%)
Similarity:	313/706 - (44%)	Gaps:	127/706 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 RILEKTEAEMK---FRGNGKLLWNLTKNSLAQQSPNGIAKKVLPAS----SYSTVQKTIPLEQPN 73
            |:..||..|.|   :...||.:...||..|      |:...:..|.    |:......:||  ||
Worm   123 RLSIKTLLEYKGWMYESPGKPVSKATKLWL------GVLHIISKAGPMLHSFQGALPRLPL--PN 179

  Fly    74 LLKYHVLPLEETLNRFMTTVEPLLTPEEFQRQKGITSEFLKKQGRELQLLLEETGSKEKNWLAHR 138
                    |::|:.:.:.:::|:|:.||||..:.::..|.|..||.||..|........|::...
Worm   180 --------LDDTVRKHLLSMKPILSDEEFQELEFLSERFRKGVGRRLQRYLTLKSWFSSNYVTDW 236

  Fly   139 WLKAAYLTYRDPVTV------FVSPGMTFPKQNFRDSRAFVDYTARVIYGLGEFNDMVH------ 191
            |.:..|:..|.|:.:      |.:.. ..|.||.....|.:.||:.      :|..||.
Worm   237 WEEFVYMRQRSPIMINSNYYGFDTLN-EHPTQNQASRAANLTYTSL------QFRRMVDRQEVSP 294

  Fly   192 -----ANKIPIVKMGKNELDNSQFGKVFGTCRIPRRGTDEIVYNPDSDYVVVIYKNHFYQLKIYS 251
                 ..|:|...|        |:.::|.|||:|....|.:::..|:.::.|..:..:::|.:::
Worm   295 FSISPRTKVPFCTM--------QYERLFNTCRVPGEEVDRLLHWDDAKHIAVYCRGVWFKLIVHN 351

  Fly   252 KEGKLIAAPC-LAAQLENIVL---KETQVGVPYGILTTDSRDNWAEAYEYLVETPGNRDALKTIQ 312
              ||.:...| |..|.:.|:.   :.::..:....||...|.:||:.......:..|:.:|..|:
Worm   352 --GKRLLEACELQVQYDAILAHTHEPSEGEMHLASLTAGERADWAKTRRAHFRSGVNKTSLNDIE 414

  Fly   313 GALFTVSLDEGTILKEGEET----------DELILSLIHGSGSKINSGNRWMDKTIQLVVNPNGN 367
            .|.|.|.||:       |||          |....:|:||     .:.:||.||:..|:::.||:
Worm   415 RAAFVVILDD-------EETHYDPQDPSKLDHWAHNLLHG-----KAHDRWFDKSFNLIISKNGH 467

  Fly   368 VGFTYEHSPAEGQPIAMMMDYVVQKMKEDPSF---GQSGSQDFAPAQKIQ--------FSSSNKS 421
            ||...|||..:.   |:|..:....:.:|..|   .::|.....|.:|:.        .:.:...
Worm   468 VGINTEHSWGDA---AVMAHFTEWSLLQDIVFIGYDENGRCKGEPKEKLTPERLKWEIPAPALDQ 529

  Fly   422 LEKSLNVAQENVDKLADALQMKVLKFNGFGKDFIKKQRLGPDSFVQMALQLAFYKMHSEPPAQYE 486
            :.||:.||..   .:|| ::|.:|.:..:||.|.||.::.||:|:||.||..::|..::....||
Worm   530 IRKSMEVANA---LIAD-VEMSLLVWTDYGKGFAKKLKVSPDAFLQMTLQYTYFKNQNKFSLTYE 590

  Fly   487 SAHLRIFDGGRTETIRSCSNESLAFSRAMQDPNVTDQERAAKLREAVVSHQTYAKLALQGKGVDR 551
            ::..|:|..|||||:|||:.:|..|.|:|.|.:.|.|:|...||:|...||...:.|:.|:||||
Worm   591 ASMTRLFREGRTETVRSCTVQSSDFVRSMLDASKTPQDRLQLLRKACDKHQELYRDAMCGQGVDR 655

  Fly   552 HLLGLKLMA--LEHSKPIPEFFKSPGFVKSSHFRMSTSQVATK-----------------YDAFM 597
            ||..|.::.  ||...|..:....|.::      :||||....                 ..|..
Worm   656 HLFALYVIKRYLEEESPFFDNIFPPTYL------LSTSQTPMNQCEADAKGLSNEVRLRLITAGG 714

  Fly   598 GYGPATDDGYACCYNPRDNDII-LAISAWRHCPITDHLKFVKTLEQSFFEMKNVLE 652
            |:||..|.||...|.....|.: ..||:.|....|...:|.:.|::|..:||.:.|
Worm   715 GFGPVADRGYGVSYIVAGEDTLSFHISSKRSADNTSSREFREELKRSLNDMKKLAE 770

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CRAT	NP_001287195.1	Carn_acyltransf	74..648	CDD:279140	167/635 (26%)
cpt-1	NP_496721.2	CPT_N	1..46	CDD:293093
cpt-1	NP_496721.2	Carn_acyltransf	172..766	CDD:279140	171/645 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D559299at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920