DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CRAT and Crat

DIOPT Version :9

Sequence 1:	NP_001287195.1	Gene:	CRAT / 40787	FlyBaseID:	FBgn0037440	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	XP_006497708.1	Gene:	Crat / 12908	MGIID:	109501	Length:	631	Species:	Mus musculus

Alignment Length:	631	Identity:	220/631 - (34%)
Similarity:	365/631 - (57%)	Gaps:	26/631 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 PNGIAKKVLPASSYSTVQKTIPLEQPNLLKYHVLPLEETLNRFMTTVEPLLTPEEFQRQKGITSE 111
            |.|:.|    .||...|.......|..|.:..|.||:::|:.::..::|:::.||:...|.:..|
Mouse    12 PLGLLK----PSSLMKVSGRFKAHQDALPRLPVPPLQQSLDYYLKALQPIVSEEEWAHTKQLVDE 72

  Fly   112 FLKK--QGRELQLLLEETGSKEKNWLAHRWLKAAYLTYRDPVTVFVSPGMTFPKQNFRDSRAFVD 174
            |...  .|..||..||....|.:|||:..|||.|||.:|.||.::.|||:..|||:|.|.:..:.
Mouse    73 FQTSGGVGERLQKGLERRAKKMENWLSEWWLKTAYLQFRQPVVIYSSPGVILPKQDFVDLQGQLR 137

  Fly   175 YTARVIYGLGEFNDMVHANKIPIVKMGKNELDNSQFGKVFGTCRIPRRGTDEIV-----YNPDSD 234
            :.|::|.|:.:|..|:....:|:..:|...|..:|:.::..:||:|....|.:|     ..|.:
Mouse   138 FAAKLIEGVLDFKSMIDNETLPVEFLGGQPLCMNQYYQILSSCRVPGPKQDSVVNFLKSKRPPT- 201

  Fly   235 YVVVIYKNHFYQLKIYSKEGKLIAAPCLAAQLENIVLKETQVG-VPYGILTTDSRDNWAEAYEYL 298
            ::.|::...|::|.:|..:|..:.:..:..|||.|.....|.. .|.||||::.|:.||:||..|
Mouse   202 HITVVHNYQFFELDVYHSDGTPLTSDQIFVQLEKIWNSSLQSNKEPVGILTSNHRNTWAKAYNNL 266

  Fly   299 VETPGNRDALKTIQGALFTVSLDEGTILKEGEET--DELILSLIHGSGSKINSGNRWMDKTIQLV 361
            ::...||:::.:||.::|||.||: .:.:..::.  :.:...::||.|||.||||||.|||:|.:
Mouse   267 IKDKVNRESVNSIQKSIFTVCLDK-QVPRVSDDVYRNHVAGQMLHGGGSKFNSGNRWFDKTLQFI 330

  Fly   362 VNPNGNVGFTYEHSPAEGQPIAMMMDYVVQKMKEDPSFGQSGSQDFAPAQKIQFSSSNKSLEKSL 426
            |..:|:.|..|||:.|||.||..::|:|::..|: |...:|........:|::|:.: ..::..:
Mouse   331 VAEDGSCGMVYEHAAAEGPPIVALVDHVMEYTKK-PELVRSPMVPLPMPKKLRFNIT-PEIKNDI 393

  Fly   427 NVAQENVDKLADALQMKVLKFNGFGKDFIKKQRLGPDSFVQMALQLAFYKMHSEPPAQYESAHLR 491
            ..|::|:..:...|.:.:|.|:.|||||.|.::|.||:|:|:|||||:|:::.:..|.||||.||
Mouse   394 EKAKQNLSIMIQDLDIMMLTFHHFGKDFPKSEKLSPDAFIQVALQLAYYRIYGQACATYESASLR 458

  Fly   492 IFDGGRTETIRSCSNESLAFSRAMQDPNVTDQERAAKLREAVVSHQTYA-----KLALQGKGVDR 551
            :|..|||:||||.|.:||||.:.|.|..|.:|::...||:||.:|:.|.     ..|::|:..||
Mouse   459 MFHLGRTDTIRSASIDSLAFVKGMGDSTVPEQQKVELLRKAVQAHRAYTDRISHPQAIRGEAFDR 523

  Fly   552 HLLGLKLMALEHSKPIPEFFKSPGFVKSSHFRMSTSQVATKYDAFMGYGPATDDGYACCYNPRDN 616
            |||||||.|:|....:|:.|....:..:.||.:|||||..|.|..|.:||...|||..||||.:.
Mouse   524 HLLGLKLQAIEDLVSMPDIFMDTSYAIAMHFNLSTSQVPAKTDCVMFFGPVVPDGYGICYNPMEA 588

  Fly   617 DIILAISAWRHCPITDHLKFVKTLEQSFFEMKNVLEKNPPETKSKL 662
            .|..::||:..|..|:..:....||::..:|:.:|:.:|   ::||
Mouse   589 HINFSVSAYNSCAETNAARMAHYLEKALLDMRTLLQNHP---RAKL 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CRAT	NP_001287195.1	Carn_acyltransf	74..648	CDD:279140	208/588 (35%)
Crat	XP_006497708.1	Carn_acyltransf	35..620	CDD:376382	208/588 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849379
Domainoid	1	1.000	398	1.000	Domainoid score	I746
eggNOG	1	0.900	-	-		E1_KOG3717
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H598
Inparanoid	1	1.050	408	1.000	Inparanoid score	I1860
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59015
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001049
OrthoInspector	1	1.000	-	-		otm43021
orthoMCL	1	0.900	-	-		OOG6_102174
Panther	1	1.100	-	-	LDO	PTHR22589
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2058
SonicParanoid	1	1.000	-	-		X630
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790