DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CRAT and CPT1C

DIOPT Version :9

Sequence 1:	NP_001287195.1	Gene:	CRAT / 40787	FlyBaseID:	FBgn0037440	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	XP_024307116.1	Gene:	CPT1C / 126129	HGNCID:	18540	Length:	836	Species:	Homo sapiens

Alignment Length:	697	Identity:	184/697 - (26%)
Similarity:	305/697 - (43%)	Gaps:	130/697 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 PNGIAKKVLPASSYSTVQKTIPLEQPNLLKYH-------VLPLEETLNRFMTTVEPLLTPEEFQR 104
            |:|....  |..::..:.:......|.|..|.       |..:::|:.:::.:|.|:|:.|:|..
Human   139 PHGAMSS--PTKTWLALVRIFSGRHPMLFSYQRSLPRQPVPSVQDTVRKYLESVRPILSDEDFDW 201

  Fly   105 QKGITSEFLKKQGRELQLLLEETGSKEKNWLAHRWLKAAYLTYRDPVTV----------FVSPGM 159
            ...:..|||:.|...||..|........|:::..|.:..||..|:|:.|          :|:|
Human   202 TAVLAQEFLRLQASLLQWYLRLKSWWASNYVSDWWEEFVYLRSRNPLMVNSNYYMMDFLYVTP-- 264

  Fly   160 TFPKQNFRDSRAFVDYTARVIYGLGEFNDMVHANKIPIVK------------------------- 199
             .|.|..|...|        ::.|..:...::..:||.|:
Human   265 -TPLQAARAGNA--------VHALLLYRHRLNRQEIPPVRGPQWVRDGGVVLWPLGHVGPGRQLT 320

  Fly   200 ---------MGKNELDNSQFGKVFGTCRIPRRGTDEIVYNPDSDYVVVIYKNHFYQLKIYSKEGK 255
                     ||...|.::|:.|:|.|.|||....|.|.:..||.:|.|.::..|:::..:|: ..
Human   321 AHGFLQTLLMGMRPLCSAQYEKIFNTTRIPGVQKDYIRHLHDSQHVAVFHRGRFFRMGTHSR-NS 384

  Fly   256 LIAAPCLAAQLENIVLKETQVGVPY----GILTTDSRDNWAEAYEYLVETPGNRDALKTIQGALF 316
            |::...|..|.:.| |.:.....|:    ..||...|..||:....|.....  :||:.::||.|
Human   385 LLSPRALEQQFQRI-LDDPSPACPHEEHLAALTAAPRGTWAQVRTSLKTQAA--EALEAVEGAAF 446

  Fly   317 TVSLD--EGTILKE--GEETDELILSLIHGSGSKINSGNRWMDKTIQLVVNPNGNVGFTYEHSPA 377
            .||||  ...:.:|  ....|....:|:.|.|.     :||.||:..|:|..||.:|.:.|||.|
Human   447 FVSLDAEPAGLTREDPAASLDAYAHALLAGRGH-----DRWFDKSFTLIVFSNGKLGLSVEHSWA 506

  Fly   378 EGQPIAMMMDYVVQ--------------KMKEDPSFGQSGSQDFAPAQKIQFSSSNKSLEKSLNV 428
            :......|.::.:.              |...||:..|        .|::|:...:: :..|:::
Human   507 DCPISGHMWEFTLATECFQLGYSTDGHCKGHPDPTLPQ--------PQRLQWDLPDQ-IHSSISL 562

  Fly   429 AQENVDKLADALQMKVLKFNGFGKDFIKKQRLGPDSFVQMALQLAFYKMHSEPPAQYESAHLRIF 493
            |......|::.:...|:.|:.|||.||::..|..|||:|:|||||.::...:....||||..|:|
Human   563 ALRGAKILSENVDCHVVPFSLFGKSFIRRCHLSSDSFIQIALQLAHFRDRGQFCLTYESAMTRLF 627

  Fly   494 DGGRTETIRSCSNESLAFSRAMQDPNVTDQERAAKLREAVVSHQTYAKLALQGKGVDRHLLGLKL 558
            ..|||||:|||:.|:..|.|||:|...||.:..|..|.||..||...|.|:.|:||||||..|.:
Human   628 LEGRTETVRSCTREACNFVRAMEDKEKTDPQCLALFRVAVDKHQALLKAAMSGQGVDRHLFALYI 692

  Fly   559 MALEHSKPIPEF--FKSPGF--VKSSHFRMSTSQVATK---------YDAFM----GYGPATDDG 606
                    :..|  .:||..  |.|..:::||||:..:         |..::    |:|||.|.|
Human   693 --------VSRFLHLQSPFLTQVHSEQWQLSTSQIPVQQMHLFDVHNYPDYVSSGGGFGPADDHG 749

  Fly   607 YACCY-NPRDNDIILAISAWRHCPITDHLKFVKTLEQSFFEMKNVLE 652
            |...| ...|..|...||:.:....||..:..:.:|.:..::.::.:
Human   750 YGVSYIFMGDGMITFHISSKKSSTKTDSHRLGQHIEDALLDVASLFQ 796

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CRAT	NP_001287195.1	Carn_acyltransf	74..648	CDD:279140	180/664 (27%)
CPT1C	XP_024307116.1	CPT_N	1..46	CDD:318644
CPT1C	XP_024307116.1	Carn_acyltransf	171..788	CDD:307070	178/653 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D559299at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920