DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ap2a2 and AP-2alpha

DIOPT Version :9

Sequence 1:	XP_031755830.1	Gene:	ap2a2 / 407867	XenbaseID:	XB-GENE-486024	Length:	1011	Species:	Xenopus tropicalis
Sequence 2:	NP_995607.1	Gene:	AP-2alpha / 33211	FlyBaseID:	FBgn0264855	Length:	952	Species:	Drosophila melanogaster

Alignment Length:	996	Identity:	646/996 - (64%)
Similarity:	761/996 - (76%)	Gaps:	84/996 - (8%)

- Green bases have known domain annotations that are detailed below.

Frog    23 CKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNK 87
            |||||||:||||||||||||||||||.||||.|||||||||||||||||||||||||||||||||
  Fly    34 CKSKEAEVKRINKELANIRSKFKGDKTLDGYQKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNK 98

Frog    88 YTEKQIGYLFISVLVNSNSELIRLINNAIKNDLSSRNPTFMGLALHCIANVGSREMAEAFAGEIP 152
            |:||||||||||||||:||:|||||..:|||||.||||..:.|||.||||:|||:|||:|:.|||
  Fly    99 YSEKQIGYLFISVLVNTNSDLIRLIIQSIKNDLQSRNPVHVNLALQCIANIGSRDMAESFSNEIP 163

Frog   153 RILVAGDTMDSVKQSAALCLLRLYRTSPDLVLTNEWTSRVVHLLNDQHLGVVTAATSLITTLAQK 217
            ::||:|||||.||||||||||||:|:|||::...|||||::|||||||:||||||||||..|.::
  Fly   164 KLLVSGDTMDVVKQSAALCLLRLFRSSPDIIPGGEWTSRIIHLLNDQHMGVVTAATSLIDALVKR 228

Frog   218 NPEEFKTSVSLAVSRLSRIVTSASTDLQDYTYYFVPAPWLSVKLLRLLQCY-PPPEDPAVRGRLT 281
            ||:|:|..|:|||||||||||::.|||||||||||||||||||||||||.| |..|:..||.||.
  Fly   229 NPDEYKGCVNLAVSRLSRIVTASYTDLQDYTYYFVPAPWLSVKLLRLLQNYNPVTEEAGVRARLN 293

Frog   282 ECLETILNKAQEPPKSKKVQHSNAKNAVLFEAISLIIYHDSEPNLLVRACNQLGQFLQHRETNLR 346
            |.|||||||||||||||||||||||||||||||:|||:.||||||||||||||||||.:||||||
  Fly   294 ETLETILNKAQEPPKSKKVQHSNAKNAVLFEAINLIIHSDSEPNLLVRACNQLGQFLSNRETNLR 358

Frog   347 YLALESMCTLASSEFSHEAVKTHIETVINALKTERDVSVRQRAVDLLYAMCDRSNAQQIVAEMLS 411
            ||||||||.||:||||||.||.|.|.||.::|.|:||||||.|||||||||||.||::||.|||:
  Fly   359 YLALESMCHLATSEFSHEEVKKHQEVVILSMKMEKDVSVRQMAVDLLYAMCDRGNAEEIVQEMLN 423

Frog   412 YLETADYSIREEIVLKVAILAEKYAVDYTWYVDTILNLIRIAGDYVSEEVWYRVIQIVINRDDVQ 476
            ||||||||||||:||||||||||||.|||||||.|||||||||||||||||||||||||||::||
  Fly   424 YLETADYSIREEMVLKVAILAEKYATDYTWYVDVILNLIRIAGDYVSEEVWYRVIQIVINREEVQ 488

Frog   477 GYAAKTVFEALQAPACHENLVKVGGYILGEFGNLIAGDPRSSPLIQFNLLHSKFHLCSVPTRALL 541
            |||||||||||||||||||:||||||||||||||||||.||:||:||.|||||:||||..|||||
  Fly   489 GYAAKTVFEALQAPACHENMVKVGGYILGEFGNLIAGDSRSAPLVQFKLLHSKYHLCSPMTRALL 553

Frog   542 LSAYIKFINLFPEIKTTIQDVLRSDSQLRNADVELQQRAVEYLRLSSIASNDILATVLEEMPPFP 606
            ||.|||||||||||:|.||||.|..|.||:||.||||||.|||:||.:||.|:|||||||||.||
  Fly   554 LSTYIKFINLFPEIRTNIQDVFRQHSNLRSADAELQQRASEYLQLSIVASTDVLATVLEEMPSFP 618

Frog   607 ERESSILAKLKKKKGPSTVTDLEETKKEKSNSDLNGITEHAPLSTTQQPVFEDKATYAVRQRPLS 671
            ||||||||.||||| |..|.: .|.::.||         .|||::..|
  Fly   619 ERESSILAVLKKKK-PGRVPE-NEIRESKS---------PAPLTSAAQ----------------- 655

Frog   672 LLVPTLSSSQSLYSGTSHRVAALPFCQSTPSPSADLLGLGA------ASGSSSTPTTAPSAGSLL 730
                    :.:|.:.:..::       :..:.:.|||||..      .|||:|..|        |
  Fly   656 --------NNALVNNSHSKL-------NNSNANTDLLGLSTPPSNNIGSGSNSNST--------L 697

Frog   731 VDVFAEPSLPVAAVTTEADDNFPSDVQTPLEGASGEPDPSVDNAEDFFDKFICKNNGVLFENQLL 795
            :||..              |.:.|:        |.....:|.|.:    ||:.|||||||||::|
  Fly   698 IDVLG--------------DMYGSN--------SNNNSSAVYNTK----KFLFKNNGVLFENEML 736

Frog   796 QIGIKSEFRQNLGRMFIFFGNKMSSQFQNFTTTLICSDELSASLNLQSKPAEPTIDGGAQVQQVV 860
            |||:||||||||||:.:|:|||......||...|..|.|.:..||:|.|..|||::.|||:||::
  Fly   737 QIGVKSEFRQNLGRLGLFYGNKTQVPLTNFNPVLQWSAEDALKLNVQMKVVEPTLEAGAQIQQLL 801

Frog   861 NVECVQEFTDLPLLNIQFRYGGAFQNVSVKLPITLNKFFQPTEMNSQDFFQRWKQLSSPNQEVQK 925
            ..||::::.|.|.:.|.|||.|..|..|:|||:::||||:|||||::.||.|||.||...|..||
  Fly   802 TAECIEDYADAPTIEISFRYNGTQQKFSIKLPLSVNKFFEPTEMNAESFFARWKNLSGEQQRSQK 866

Frog   926 IFKAKNPMDTDITKARLIGFGPAVMDNVDPNPSNYVAAGIIQAKTRQVGCLLRLEPNEQAQMYRL 990
            :|||..|:|....:.:|:|||..::|.|||||.|.|.||||..:::|||||:|||||:||||:||
  Fly   867 VFKAAQPLDLPGARNKLMGFGMQLLDQVDPNPDNMVCAGIIHTQSQQVGCLMRLEPNKQAQMFRL 931

Frog   991 TIRTSKEEVSQTLCDLLSEQF 1011
            |:|.|||.|::.:||||::||
  Fly   932 TVRASKETVTREICDLLTDQF 952

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ap2a2	XP_031755830.1	Adaptin_N	29..591	CDD:396262	457/562 (81%)
		HEAT repeat	332..355	CDD:293787	20/22 (91%)
		HEAT repeat	369..398	CDD:293787	20/28 (71%)
		HEAT repeat	408..434	CDD:293787	23/25 (92%)
		Alpha_adaptinC2	789..892	CDD:197886	51/102 (50%)
		Alpha_adaptin_C	898..1006	CDD:367023	61/107 (57%)
AP-2alpha	NP_995607.1	Adaptin_N	40..598	CDD:279882	455/557 (82%)
		Alpha_adaptinC2	730..839	CDD:197886	54/108 (50%)
		Alpha_adaptin_C	839..947	CDD:280460	61/107 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	906	1.000	Domainoid score	I53
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5335
Inparanoid	1	1.050	1254	1.000	Inparanoid score	I175
OMA	1	1.010	-	-		QHG53727
OrthoDB	1	1.010	-	-		D751651at2759
OrthoFinder	1	1.000	-	-		FOG0002465
OrthoInspector	1	1.000	-	-		otm49317
Panther	1	1.100	-	-	LDO	PTHR22780
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1882
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.080