Protein Alignment CG10286 and Heatr3

DIOPT Version :10

• Sequence 1: NP_649649.1
• Gene: CG10286 / 40786
• FlyBaseID: FBgn0037439
• Length: 625
• Species: Drosophila melanogaster
• Sequence 2: NP_766345.3
• Gene: Heatr3 / 234549
• MGIID: 2444491
• Length: 679
• Species: Mus musculus
• Alignment Length: 685
• Identity: 181/685 - (26%)
• Similarity: 314/685 - (45%)
• Gaps: 83/685 - (12%)

  Fly     1 MGKVRKVKTRTP--SGVDT-SAEIDVES--AGEAEGCGPIEAICVHLQQANVEEKLNGLHSFAVL 60
            |||.|..:.:.|  |.::: .||....|  .|:.|..||...:...||..:.|.:.......|.|
Mouse     1 MGKSRTKRFKRPQFSPIESCQAEAAAASNGTGDEEDDGPAAELLEKLQHPSAEVRECACAGLARL 65

  Fly    61 ALRKEKVPEIRDSELVRIAAPLLCDKESAIRNAAAGAFRNLSVF-GTEVCDFLVENDILTALLTL 124
            ..::..:|::...:.||...|||.|...|:|..||||.||||.. |.:|||.:|..||:|.|:.|
Mouse    66 VQQRPALPDLARRDAVRRLGPLLLDSSLAVRETAAGALRNLSACGGFDVCDDMVAKDIMTPLVAL 130

  Fly   125 VRSYDLTKGGFENEL----HAD-------TFQQAIHLLRNLCESSPTATEALNQANFLSSLLLGF 178
            :|  :...|...||:    .||       ...:|:::|.|:||.|..|....|:...|..:|
Mouse   131 LR--ECLSGLDSNEMSPQEKADKRNPVESIANEAVNVLWNVCECSGRAVSIFNKEGCLEIVL--- 190

  Fly   179 DY-RKF--GLEVAISVAQLVLVVSENNSSSWNVLASST--ILPELLVAPTESHAQLYLNALAAGI 238
            .| |:|  .:::|:|||..:..|:|:|.........:.  :|...|:.|..|...:.|..|.||.
Mouse   191 QYLRRFPTSIDLAVSVAYCLQTVTEDNPELLKSFDGTALRVLESALLCPVASMEYILLKTLVAGT 255

  Fly   239 LCN----VPACAAAH-TREILNSLDKLLSIDP-QAQLQSCKSEILNAKSKNEAPVLEISMETEDM 297
            :.|    :|:.:.|. ...||.:|.::|.::. ...:|..::|....|:..|:..:..:...:|:
Mouse   256 IWNLKDIIPSKSQAEIINAILGALSEVLGMNTGNMVIQMKEAETQRLKTAAESEDILANANGDDL 320

  Fly   298 TETQSANQSKPNQ---------------CDAEVALKNLEHLLDAQRLVAEIITNLGSSDEQSN-- 345
            .|.....:. |::               .|.|  |:....||.||:...|:|.|:..|::.|:
Mouse   321 VEDDEMEEI-PHKRKLRRKTFISDLLPPTDKE--LREAMALLTAQQTALEVIVNMCCSEDPSDDE 382

  Fly   346 WDTDSEHSESESVADYDMEDETADSGSGGLP-----ANFLETIKQNKVI-EKLWQKAQPLQPAVE 404
            |:..|...|||:.    ||:..::. ||.|.     ::.:.:...|.:| ||:::|.........
Mouse   383 WEELSSSDESEAF----MENSFSEC-SGHLMSPLCLSHEIHSALTNCLIPEKVFEKTSSPNSVAV 442

  Fly   405 NLVSQQENIK---EKVEKLRVSYLICLQNLCNVLPPEDLGGCSNLYNM-----WMILGQQAFRGS 461
            ::.|:....|   .|:..::...|:|||:|.::|..:.|||...|..:     .::..|..|...
Mouse   443 DICSKNPTWKPLIRKMNTIQCRALMCLQSLVSLLDIDHLGGAPALQTLAQHLSQILFSQPDFAKH 507

  Fly   462 EDVSVMEAITSLMRSSLSLLKSRKDLFGQMTENDLNMIIEGASKCTDINIRVNWNRMLGTLGSLL 526
            :|  .:|||:|.:|:.|..:.| |::...||...|..:.......:.|.:|||...:||..||:|
Mouse   508 DD--FLEAISSALRALLQTMAS-KNIPQCMTPEQLMTLCREGIHSSSIGVRVNVVSILGITGSVL 569

  Fly   527 SE-----PLVKAIVLFLLTYCAQEDDLWALSEGLDALMDIFAVDDWPQ-IIAELEMCDRVQALEE 585
            ::     ..:|.|..|||....::..|....|.||||.|:||..:..: ...::::...::..:.
Mouse   570 AKDDGTLDTLKTIGCFLLEVATKDPSLVVTGEALDALFDVFADGEAAEKASVQIKLLAALKEFQP 634

  Fly   586 LFKSKLRQQRR--ELKERRATVQTVKTNFSRFVFY 618
            :||.|:|::.|  ...::...:..||.|..||:.|
Mouse   635 VFKMKIRKEGRGKYSPDQLCVLDNVKMNLRRFIAY 669

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10286	NP_649649.1	Syo1_like	41..621	CDD:474028	168/640 (26%)
Heatr3	NP_766345.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..40		12/38 (32%)
		Syo1_like	2..672	CDD:240521	180/684 (26%)
		HEAT 1	38..69		7/30 (23%)
		armadillo repeat	69..108	CDD:293788	16/38 (42%)
		HEAT 2	74..110		16/35 (46%)
		armadillo repeat	115..169	CDD:293788	16/55 (29%)