DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42724 and FIP1[V]

DIOPT Version :9

Sequence 1:	NP_001189184.1	Gene:	CG42724 / 40785	FlyBaseID:	FBgn0261641	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	NP_200612.2	Gene:	FIP1[V] / 835916	AraportID:	AT5G58040	Length:	1196	Species:	Arabidopsis thaliana

Alignment Length:	1189	Identity:	240/1189 - (20%)
Similarity:	401/1189 - (33%)	Gaps:	370/1189 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 GASSPITKTE-ATESPPEAGLNGNGSGSGSTSQETPNYGVAILKEKPSEAHRSKPFNAFSGRP-I 75
            |.|...|:.| ......:.|..|.|.|....|....:..:.:     :::.|:........|. :
plant   117 GVSQVTTRIEQQVGGGGDGGYGGQGEGDDWDSDSEDDLQIVL-----NDSSRNVMIGGADRRSRM 176

  Fly    76 GEHTAQQQALQQQQL--QQQQQPQQPQQQAPSGANGVTGPPEIWVETKAEDGRSYYYHAVTRETT 138
            |::........:..|  .....|.||.::...|.:|:.|     :|...:||...
plant   177 GDNEDDDDEDDEDPLVIVADTDPNQPMEEQMWGEDGLQG-----IEGDGKDGGEA---------- 226

  Fly   139 WSRPDGPAVKIMTQAEVEEMAKRPAQAAKTEAKAGETSVEIPPVSSHLTSQPPPHLMSQPPPNAA 203
             .:..||.                  .|....|||.:|....|..|......|.   :.|.|..|
plant   227 -GKGSGPG------------------GATGPPKAGYSSHGYHPFHSQFKYVRPG---AAPIPGGA 269

  Fly   204 A----PLLSQ--PPPNVRQQPPPM-------FQPPGMQ----APPGFGQP----------PFCMP 241
            |    |...|  ||.|:    .||       ::|.||:    |..||.||          .|.:|
plant   270 ASVGGPSSGQVRPPANL----GPMAGRGRGDWRPLGMRNASAAQKGFHQPWGSNTAGRGLDFTLP 330

  Fly   242 --------------PPTYGFPGGPAPAGAPWGVGIPPW-----QQQQH-----MQ---------- 272
                          ...:.:||........:|:....|     |..||     ||
plant   331 SHKTIFEVDIDSFEEKPWRYPGVEMTDYFNFGLNEESWKDYCKQLDQHRIQTTMQSRIRVYESGR 395

  Fly   273 -------DKPAK--------------SLIIKPGVID------PAVIARAAEWSEHRAPDGRPYYF 310
                   |.|.:              |.::||..:.      ||.:       ....|.|||...
plant   396 TDQGYDPDLPPELAAATGAQGVPVDSSNLVKPDSVQGDSAKVPANV-------RPTLPPGRPIPV 453

  Fly   311 HAGRGE---SVWEKPQALRDMEAARMAAHSGVAPAVATAPSGLPPHLLPNPMMHMPPGSGPPGFD 372
            ..|.||   |:..:...:||::|        :...|...             .|....||..|.|
plant   454 ETGSGERLPSIDTRAPRMRDLDA--------IIEIVCQD-------------SHEDEPSGENGTD 497

  Fly   373 ------PHAAFAAAAAAMKANSENTKAAQAAALEKEAKKAAEEKRKKEEEQKKAAASAKQTDKSR 431
                  |........:.:.....:|::|:.:..:.|..|  ...:|:::|..::..|.:....|.
plant   498 QADSSLPGENVPVETSYVNNKRPDTESAEHSPAQDEPHK--NLLKKQDDEISRSTDSGQSFRSSS 560

  Fly   432 PVTSTPIAGTPWCVVWTGDSRVFFYNPSTRTSVWDRPEDLLNREDVDKAVNERPEQLK----TPQ 492
            ||               ||.       .||:|..|| ||:......|.   |..|:||    :||
plant   561 PV---------------GDR-------GTRSSSVDR-EDVGGEAGKDA---EMGEELKMSFTSPQ 599

  Fly   493 EKSAEAEQKSGE---EANQEQAKSQVQAQQLDQVQRVDADDDDDDEVIKIRTESESSVEEVPTKR 554
              ||..|...||   |.:.|.:|::..:.:         |...:::||:.:..|.      |...
plant   600 --SAVQEDDGGESKTERSSESSKARSGSHR---------DFQQEEDVIQDKHSSR------PANN 647

  Fly   555 VRMIS-----KSKRAEDAALEAEQ-RAA----KERALVPLEMRVTQFKEML--------REKDVS 601
            .:...     :|::.:|...|.|: |||    :|.:...:|:..|....:.        :|:||.
plant   648 RKQYDNNAPHQSRKNQDRGKEMERTRAASKGGRENSNPHMELDSTYIYSIASREDFDKRKERDVD 712

  Fly   602 AFSTWEKELHKIVFDPRYLLLTSKE--RKQVFEKYVKDRAEEERKEKRNKMRQ----KRED---F 657
            . :.|.::     .|..|......|  ||       :||.::....:|.|||:    .::|   .
plant   713 G-AVWRRK-----EDDPYSRRGGDEGSRK-------RDREDDPGFRQRGKMRENEIRSKDDQVPS 764

  Fly   658 RSLMEEARLHGKSSFSEFSQRNAKDERYRAIEKVRERESLFNEYIVEVR-RREKEDKLLKKE--- 718
            |..|::|.:.......:...:..|||.|....:..:.|..:.:.....| :||::|:|..::
plant   765 RKHMDDAGMRNIYEPDDHINKRRKDEEYLRRSRPEKNEISYGQRESMSRVKRERDDRLEHQKRDV 829

  Fly   719 --QIRKDFLD--MLRERHDI------ERHTRWYDIKKKFE------------------------S 749
              :||.||.|  .||:|.||      ....|..|:..|.:                        .
plant   830 QHKIRDDFDDHGSLRQRDDIYMQRDGNERLRERDVLDKLKLPHEDGISARGRERQVAVRGHRGSE 894

  Fly   750 DPRYRMVD---SMYREEYFEDYLHIMKEEKRKEREMREQRERERHRELKSDRKEK--DKEKDKGR 809
            |...||.|   :..:|...:|.|...|:.||::....|.....|..|..|.|.:.  :.|| |.|
plant   895 DRSSRMKDEYKASDKEHVTKDTLRHAKQTKRRDYPGEESSSHHRGHEDFSARTDNIVNNEK-KPR 958

  Fly   810 KDRGRSR----------SKDKDREHKSSKEKDKDKEEKSKSEKSKKRDTTPEEGEHREESEREER 864
            ::|..::          .:.:||:||.|:.|.|::.|.::|        ..::||....|.....
plant   959 QERTGAKIDKFIDTLDGQRLQDRKHKDSRRKIKEQREGTES--------LSKQGEQNGSSVVTGS 1015

  Fly   865 AGSDD-----SEVARQRENEAEQKQ-----------KEREKKLRVEQSIREREKEV---QRTLAG 910
            .|::|     ||:..|.......|:           |....||....|.:|||..|   ..:::.
plant  1016 KGTNDARNCRSEIPHQPNTAKRHKENASSGDEIHDSKRGRTKLERWASHKEREDAVSAKSSSISS 1080

  Fly   911 HLRDRDKEREHHMREECIGHFTALLTDLVRTPDFTWKEVKRQLRKDHRWELIESLDREDRERK-- 973
            .|.:::......:.|...|       .:.::.|.|.:::...|           .|.:|...|
plant  1081 KLEEKENNTNGRLSEPVHG-------SIGKSRDVTEEKIGHDL-----------ADTKDGSEKGP 1127

  Fly   974 FNEHIDNL--MKKKRERFR 990
            .:.|:|.:  :||:.|||:
plant  1128 GDRHLDTVEKLKKRSERFK 1146

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42724	NP_001189184.1	WW	112..144	CDD:197736	4/31 (13%)
		Extensin_2	180..243	CDD:252669	24/103 (23%)
		WW	295..322	CDD:278809	8/29 (28%)
		WW	441..468	CDD:278809	6/26 (23%)
		FF	590..634	CDD:280090	9/53 (17%)
		FF	652..701	CDD:280090	9/55 (16%)
		FF	719..768	CDD:280090	18/83 (22%)
		FAT-like_CAS_C	871..>935	CDD:300863	14/77 (18%)
		FF	930..977	CDD:280090	6/48 (13%)
		FF	983..1036	CDD:128718	5/8 (63%)
		FF	1041..1096	CDD:280090
FIP1[V]	NP_200612.2	Fip1	337..379	CDD:282968	6/41 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm2836
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000