DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42724 and tcerg1b

DIOPT Version :9

Sequence 1:	NP_001189184.1	Gene:	CG42724 / 40785	FlyBaseID:	FBgn0261641	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	XP_009293957.1	Gene:	tcerg1b / 797473	ZFINID:	ZDB-GENE-101026-4	Length:	990	Species:	Danio rerio

Alignment Length:	1116	Identity:	401/1116 - (35%)
Similarity:	571/1116 - (51%)	Gaps:	279/1116 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 PIGEHTAQQQALQQQQLQQQQQPQQ---PQQQAPSGANGVTGPPEIWVETKAEDGRSYYYHAVTR 135
            |||....|:.......:.....|..   |....||.........|||||....:|:.|||:|.||
Zfish    85 PIGPPHLQRPPFMPPPMGNMPPPPGMIFPPGMPPSPGAASLPSEEIWVENNTPEGKVYYYNARTR 149

  Fly   136 ETTWSRPDGPAVKIMTQAEVEEM--------AKRPAQAAKTEAKAGETSVEIPPVSSHLTSQPPP 192
            |:.|::|:|  |||:.|:|:..:        |..|..||.....:...:|....||:.  |..|.
Zfish   150 ESAWTKPEG--VKIIQQSELNPLMAAQSGGAAAAPNSAASANVASTTATVVTDTVSTQ--SMSPS 210

  Fly   193 HLMS-QPPPNAA-APLLSQP---------PPNVRQQP--------------------------PP 220
            |.:| .|.|:.: ||..|||         ||.|...|                          |.
Zfish   211 HTLSTSPDPSTSPAPTASQPSITSVVSEMPPVVSTPPVSVSVTPVAVVSVPTVTATVTAVQTMPL 275

  Fly   221 MFQ--PPGMQAPPGFGQ---PPFCMPPPTYGFPGG--PAPAGAPWGVGIPPWQQQQHMQDKPAKS 278
            :.|  |||:...|..|.   ||..:||.....||.  |.|     |:| ||.....|.|...|.|
Zfish   276 LHQSLPPGLPVAPPAGAIPFPPVMVPPFRVPLPGMHIPLP-----GMG-PPLVPMMHPQLTIAAS 334

  Fly   279 LIIKPGVIDPAVIARAAEWSEHRAPDGRPYYFHAGRGESVWEKPQAL----RDMEAARMAAHSGV 339
            .:...|.|.      ..||||.:..|||.||::....||.||||..|    :|.:.|| ..|:.:
Zfish   335 PMSLAGAIP------LPEWSEFKTADGRIYYYNNRTLESTWEKPFELKERDKDSDKAR-DIHNNI 392

  Fly   340 APAVATAPSGLPPHLLPNPMMHMPPGSGPPGFDPHAAFAAAAAAMKANSENTKAAQAAALEKEAK 404
                     .|...|:.                           |:|.::..|          :|
Zfish   393 ---------NLDLKLID---------------------------MEAKADFGK----------SK 411

  Fly   405 KAAEEKRKKEEEQKKAAASAKQTDKSRPVTSTPIAGTPWCVVWTGDSRVFFYNPSTRTSVWDRPE 469
            :...|:...|||        |.|.|.:||.:.||.|||||||||||.|||:|||:||.|:|||||
Zfish   412 ELPREEDMTEEE--------KATQKGKPVATNPIPGTPWCVVWTGDERVFYYNPTTRLSMWDRPE 468

  Fly   470 DLLNREDVDKAVNERPEQLKTPQEKSAEAEQKSGEEANQEQAKSQVQAQQLDQVQRVDADDDDDD 534
            :|:.|.|||:.:.|.|              .|.|                ||.::::..:.::.|
Zfish   469 ELVGRADVDRYIQEPP--------------HKRG----------------LDDIKKIGFNKEEID 503

  Fly   535 EVIKIRTESESSVEEVPTKRVRM----ISKSKRAEDAALEAEQRAAKERALVPLEMRVTQFKEML 595
                  |..|..:::.|:|..:.    :.:.:.|:|.|:|||.:||::|||||||.|:.||::||
Zfish   504 ------TAMEDMLDDEPSKAKKRKKDDVKEPEAAKDVAVEAELKAARDRALVPLEARMNQFRDML 562

  Fly   596 REKDVSAFSTWEKELHKIVFDPRYLLLTSKERKQVFEKYVKDRAEEERKEKRNKMRQKREDFRSL 660
            .|:.|||||||:|||||||||||||||..|||||||::|||.|||||||||:||:.|.::|||.:
Zfish   563 LERGVSAFSTWDKELHKIVFDPRYLLLNPKERKQVFDQYVKTRAEEERKEKKNKLMQSKDDFRRM 627

  Fly   661 MEEARLHGKSSFSEFSQRNAKDERYRAIEKVRERESLFNEYIVEVRRREKEDKLLKKEQIRKDFL 725
            ||:|:||.:::||||:.:::||.|::||||:::||.:|.|::...|:::|||...|.:::::||.
Zfish   628 MEDAKLHTRTTFSEFAAKHSKDPRFKAIEKMKDREVMFTEFMTAFRKKDKEDSKNKVDKVKQDFF 692

  Fly   726 DMLRERH-DIERHTRWYDIKKKFESDPRYRMVD-SMYREEYFEDYLHIMKEEKRKEREMREQRER 788
            |:|.:.| ||.:  ||..:|.|.|:|.||:.|: |..|||:::.|:
Zfish   693 DLLSDHHVDITQ--RWSKVKDKLETDQRYKAVESSAAREEFYKQYV------------------- 736

  Fly   789 ERHRELKSDRKEKDKEKDKGRKDRGRSRSKDKDREHKSSKEKDKDKEEKSKSEKSKKRDTTPEEG 853
                                               .|.:|..|.|||
Zfish   737 -----------------------------------EKQAKNVDADKE------------------ 748

  Fly   854 EHREESEREERAGSDDSEVARQRENEAEQKQKEREKKLRVEQSIREREKEVQRTLAGHLRDRDKE 918
                                           ||.|::.|:|.|:||||:||||..:...::.|:|
Zfish   749 -------------------------------KELERQARIEASLREREREVQRARSEQTKEIDRE 782

  Fly   919 REHHMREECIGHFTALLTDLVRTPDFTWKEVKRQLRKDHRWELIESLDREDRERKFNEHIDNLMK 983
            ||.|.|||.|.||.||::|:||:.|.:|.|.:|.||||||||....|:|.::|:.|.:|::.|.|
Zfish   783 REQHKREEAIQHFRALMSDMVRSTDTSWSETRRNLRKDHRWETSSLLERHEKEKLFEDHVEALTK 847

  Fly   984 KKRERFREMLDEISTLQLTSTWKEIKKLIKEDPRYLKYNSD--KGEREFRDYIKDKTMTAKTSLR 1046
            :|:|.||::|||...:.||:.|||:||:||||||.:|::|.  |.:|||.||||||.:.||...|
Zfish   848 RKKEHFRQLLDETPMITLTTAWKEVKKIIKEDPRCMKFSSSDRKKQREFEDYIKDKYIIAKADFR 912

  Fly  1047 ELLQECKFITHKSSDLIKENPNHLKEIQDILKNDKRYLVLDHMEEERNTIVLGFLEELNKRGPPP 1111
            .||:|.||||::|..||:|:..|||:|:.:|:|||||||||.:.|||..:::.::|:|::|||||
Zfish   913 TLLKETKFITYRSRKLIQESDQHLKDIEKVLQNDKRYLVLDCVPEERRKLIMFYIEDLDRRGPPP 977

  Fly  1112 PPTASESTRRN 1122
            ||||||..||:
Zfish   978 PPTASEPCRRS 988

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42724	NP_001189184.1	WW	112..144	CDD:197736	15/31 (48%)
		Extensin_2	180..243	CDD:252669	27/104 (26%)
		WW	295..322	CDD:278809	13/26 (50%)
		WW	441..468	CDD:278809	21/26 (81%)
		FF	590..634	CDD:280090	34/43 (79%)
		FF	652..701	CDD:280090	23/48 (48%)
		FF	719..768	CDD:280090	20/50 (40%)
		FAT-like_CAS_C	871..>935	CDD:300863	26/63 (41%)
		FF	930..977	CDD:280090	23/46 (50%)
		FF	983..1036	CDD:128718	30/54 (56%)
		FF	1041..1096	CDD:280090	31/54 (57%)
tcerg1b	XP_009293957.1	WW	126..158	CDD:197736	15/31 (48%)
		WW	345..372	CDD:238122	13/26 (50%)
		WW	441..469	CDD:197736	22/27 (81%)
		FF	557..601	CDD:280090	34/43 (79%)
		FF	621..668	CDD:280090	22/46 (48%)
		FF	686..735	CDD:280090	20/50 (40%)
		DUF759	708..>801	CDD:283245	45/195 (23%)
		FF	790..841	CDD:280090	25/50 (50%)
		FF	847..902	CDD:128718	30/54 (56%)
		FF	907..966	CDD:280090	31/58 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	79	1.000	Domainoid score	I8612
eggNOG	1	0.900	-	-		E1_KOG0155
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	485	1.000	Inparanoid score	I1398
OMA	1	1.010	-	-		QHG52888
OrthoDB	1	1.010	-	-		D1388955at2759
OrthoFinder	1	1.000	-	-		FOG0002297
OrthoInspector	1	1.000	-	-		otm25195
orthoMCL	1	0.900	-	-		OOG6_103069
Panther	1	1.100	-	-	LDO	PTHR15377
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3901
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.840