DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42724 and Tcerg1l

DIOPT Version :9

Sequence 1:	NP_001189184.1	Gene:	CG42724 / 40785	FlyBaseID:	FBgn0261641	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	NP_899112.2	Gene:	Tcerg1l / 70571	MGIID:	1917821	Length:	590	Species:	Mus musculus

Alignment Length:	719	Identity:	199/719 - (27%)
Similarity:	311/719 - (43%)	Gaps:	221/719 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 QQQLQQQQQPQQP--QQQAPSGANGVTGPPEIWVETKAEDGRSYYYHAVTRETTWSRPDGPAVKI 149
            |::.:|.||||||  :|..|...| ...||..||                    |..| |.|..:
Mouse     8 QRRRRQLQQPQQPRWRQPLPWPMN-ADPPPPPWV--------------------WMVP-GTAGLL 50

  Fly   150 MTQAEVEEMAKRPAQAAKTEAKAGETSVEIPPVSSHLTSQPPPHLMSQPPPNAAAPLLSQPPPNV 214
            ...|.|                                 .|||.|::...| |:||||    |.:
Mouse    51 RLGAGV---------------------------------APPPVLLASAQP-ASAPLL----PRL 77

  Fly   215 RQQPPPMFQPPGMQAPPGFGQP-----PFCMPP---PTYGFP--------GGPAPAGAPWGVGIP 263
                      ||..||   |:|     |....|   ..:.:|        ||.:|:     :|:.
Mouse    78 ----------PGWPAP---GEPLLPLLPLSSAPDHAAVHHYPLLHGQWLFGGHSPS-----IGLA 124

  Fly   264 PWQQQQHMQDKPAKSLI-----IKPGVIDPAVIARAAEWSEHRAPDGRPYYFHAGRGESVWEKPQ 323
            |         ..|..|:     :.|..:.|.|   ...|.:.|.|:.:.::.:....:|.|..|:
Mouse   125 P---------SSAVELVPLFPHVCPSTLSPPV---GKNWIDKRMPNYKIFFNNPFALDSTWMYPE 177

  Fly   324 ALRDMEAARMAAH-------SGVAPAVA-TAPSGLPPHLLPNPMMHMPP------------GSGP 368
                 |:....:|       :.|.|::: ..|:..|   ||..::...|            ..||
Mouse   178 -----ESVLFHSHEKTHFLANQVTPSLSRPTPASRP---LPTVVLAAQPIPGGCHDSLKPISRGP 234

  Fly   369 PGFDPHAAFAAAAAAMKA-------------------------------------NSENTKAAQA 396
            ......|..||||.||.:                                     ..|:::|.::
Mouse   235 TITITAATAAAAATAMVSVDPEELRGLSPSIMQPCHFLTLTPIRIPFRTAPFSDKGKEHSRAPRS 299

  Fly   397 AAL---EKEAKKAAEEKRKKEEEQKKAAASAKQTDKSRPVTSTPIAGTPWCVVWTGDSRVFFYNP 458
            .||   ..|.|....:|..||...............::||.|||:.|:|||||||||.||||:||
Mouse   300 PALMLRAPERKSLVGDKEDKEPPPILVRGEETAAKGNKPVASTPVPGSPWCVVWTGDDRVFFFNP 364

  Fly   459 STRTSVWDRPEDLLNREDVDKAVNERPEQLKTPQEKSAEAEQKSGEEANQEQAKSQVQAQQLDQV 523
            :.:.|||::|.||.||.|:.:.:.:.|.:.|.  |.|| .|...|.
Mouse   365 TMQLSVWEKPVDLQNRGDLKRIIEDPPHKRKL--EASA-TESSDGS------------------- 407

  Fly   524 QRVDADDDDDDEVIKIRTESESSVEEVPTKRVRMISKSKRAEDAALEAEQRAAKERALVPLEMRV 588
               .:||..:|:.:|.:.....|.|....:....:.|..:.....:           |:|||.||
Mouse   408 ---SSDDGSEDQSVKTKRNRTESCEGPGPEDTHQVDKGPQTPPPQI-----------LLPLEERV 458

  Fly   589 TQFKEMLREKDVSAFSTWEKELHKIVFDPRYLLLTSKERKQVFEKYVKDRAEEERKEKRNKMRQK 653
            |.|::||.|:.|||||||||||||||||||||||.|:||||:||::||.|.:||.||:::|:...
Mouse   459 THFRDMLLERGVSAFSTWEKELHKIVFDPRYLLLNSEERKQIFEQFVKTRIKEEYKERKSKLLLA 523

  Fly   654 REDFRSLMEEARLHGKSSFSEFSQRNAKDERYRAIEKVRERESLFNEYIVEVRRREKEDKLLKKE 718
            :|:|:.|:||:::..:::|.||::::.:|:|:|.::|.:::|..||::|:.:::|:||::|
Mouse   524 KEEFKKLLEESKVSPRTTFKEFAEKHGRDQRFRLVQKRKDQEHFFNQFILILKKRDKENRL---- 584

  Fly   719 QIRK 722
            ::||
Mouse   585 RLRK 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42724	NP_001189184.1	WW	112..144	CDD:197736	6/31 (19%)
		Extensin_2	180..243	CDD:252669	19/70 (27%)
		WW	295..322	CDD:278809	5/26 (19%)
		WW	441..468	CDD:278809	18/26 (69%)
		FF	590..634	CDD:280090	34/43 (79%)
		FF	652..701	CDD:280090	15/48 (31%)
		FF	719..768	CDD:280090	2/4 (50%)
		FAT-like_CAS_C	871..>935	CDD:300863
		FF	930..977	CDD:280090
		FF	983..1036	CDD:128718
		FF	1041..1096	CDD:280090
Tcerg1l	NP_899112.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29		10/20 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	285..344		13/58 (22%)
		WW	347..374	CDD:278809	18/26 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	382..450		15/92 (16%)
		FF	456..504	CDD:280090	37/47 (79%)
		FF	523..571	CDD:280090	15/47 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	80	1.000	Domainoid score	I8580
eggNOG	1	0.900	-	-		E1_KOG0155
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002297
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR15377
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7471
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.940