DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42724 and tcerg1a

DIOPT Version :9

Sequence 1:	NP_001189184.1	Gene:	CG42724 / 40785	FlyBaseID:	FBgn0261641	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	NP_938171.2	Gene:	tcerg1a / 323071	ZFINID:	ZDB-GENE-030131-1791	Length:	1000	Species:	Danio rerio

Alignment Length:	1166	Identity:	420/1166 - (36%)
Similarity:	597/1166 - (51%)	Gaps:	297/1166 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 SQETPNYGVAILKEKPSEAHRSK----PFNAFSGRPIGEHTAQQQALQQQQLQQQQQPQQPQQQA 103
            |...|.|   .|...|..|.|..    ||:.....|:|        ....|:..|:.|..|
Zfish    44 SSPVPPY---TLMRSPPPAARPPFTRLPFDPSVPPPMG--------TPPLQVHSQRPPFMP---- 93

  Fly   104 PSGAN-----GVTGPP-----------------------------EIWVETKAEDGRSYYYHAVT 134
            |.|.:     |:..||                             |||||.|:.:|:.|||:|.|
Zfish    94 PPGGSMPPPPGMIFPPGIPPSVAPAPTPAPALAPAPAPTPLVSTEEIWVENKSPEGKVYYYNART 158

  Fly   135 RETTWSRPDGPAVKIMTQAEVEEMAKRPAQAAKTEAKAGET--SVEIPPV-----SSHLTSQPPP 192
            ||::|::|:|  ||::.||::..:..  :|||...|..|.|  ||.||..     |::..:.|..
Zfish   159 RESSWTKPEG--VKVIQQADLCPLMM--SQAAVAAAGGGSTAPSVSIPAASAVSGSTNTLAAPSA 219

  Fly   193 HLMSQPPPNAAAPLLSQPP--PNVRQQPPPMFQ-PPGMQAP-PGFGQP-------------PFCM 240
            .....|...||:|||..|.  |:|.:.|..:.. |..|..| |...||             |..:
Zfish   220 GPAVVPSITAASPLLPTPATVPDVVEMPSVVTSAPSSMPTPMPAVNQPTVSVAMTTGPPTLPVAL 284

  Fly   241 ----PPPTYGFPGGPAPAGAPWGVGIP----------PWQQQQHMQDKPAKSLIIKPGVIDPAVI 291
                |.|....||.|.....|:.|.:|          |......:...|.:..|..|..:..|:
Zfish   285 SHTVPQPATTIPGFPPVMVPPFRVPLPAMPIPLPGMLPSMAPPLVPMMPPQMTIAGPAGLPGAL- 348

  Fly   292 ARAAEWSEHRAPDGRPYYFHAGRGESVWEKPQALRDMEAARMAAHSGVAPAVATAPSGLPPHLLP 356
             ..::|:|.:.|:|:.||::....|:.|:||:.|||.|.........|            ..::.
Zfish   349 -GTSDWAEFKTPEGKSYYYNKHTQETTWDKPEELRDTEKESEKVMDSV------------EEMME 400

  Fly   357 NPMMHMPPGSGPPGFDPHAAFAAAAAAMKANSENTKAAQAAALEKEAKKAAEEKRKKEE--EQKK 419
            ..::.|..||  |..||                          .||.|    |:.|:||  |::|
Zfish   401 AEILSMEDGS--PQIDP--------------------------PKEQK----EELKEEEMTEEQK 433

  Fly   420 AAASAKQTDKSRPVTSTPIAGTPWCVVWTGDSRVFFYNPSTRTSVWDRPEDLLNREDVDKAVNER 484
            ||..||      ||.:|||.|||||||||||.|||||||:||.|:|:||||||.|.|||||:...
Zfish   434 AAKKAK------PVATTPIPGTPWCVVWTGDERVFFYNPTTRLSMWERPEDLLGRADVDKAIQAP 492

  Fly   485 PEQLKTPQEKSAEAEQKSGEEANQEQAKSQVQAQQLDQVQRVDADDDDDDEVIKIRTESESSVEE 549
            |              .|.|                ||...|:....|:.:..:     ||.:.:|
Zfish   493 P--------------HKRG----------------LDNSHRLALVKDEQEFPV-----SEDAADE 522

  Fly   550 VPTKRVRMISKSKR----AEDAALEAEQRAAKERALVPLEMRVTQFKEMLREKDVSAFSTWEKEL 610
            .|:|..|...:.|.    .::||:|||.:||:|||:||.|.|::||||||.|:.||||||||||.
Zfish   523 EPSKAKRRKVEEKMELDPEKEAAMEAELKAARERAVVPQEARISQFKEMLLERAVSAFSTWEKER 587

  Fly   611 HKIVFDPRYLLLTSKERKQVFEKYVKDRAEEERKEKRNKMRQKREDFRSLMEEARLHGKSSFSEF 675
            ||||||||||||..|||||||::|||.||||||:||:||:.|.::|||.:|||::|..:::||||
Zfish   588 HKIVFDPRYLLLNPKERKQVFDQYVKTRAEEERREKKNKIMQVKDDFRKMMEESKLGVRTTFSEF 652

  Fly   676 SQRNAKDERYRAIEKVRERESLFNEYIVEVRRREKEDKLLKKEQIRKDFLDMLRERH-DIERHTR 739
            :.::|:|.|::|:||:::||::|.|::...|::|||:...:.|:::.||.::|.:.| ||::  |
Zfish   653 AAKHARDSRFKAVEKMKDREAIFIEFMTAFRKKEKENSKNRGEKVKLDFFELLSDYHVDIQQ--R 715

  Fly   740 WYDIKKKFESDPRYRMVD-SMYREEYFEDYLHIMKEEKRKEREMREQRERERHRELKSDRKEKDK 803
            |..:|:|.|:||||:.|: |..|||:|::|
Zfish   716 WSKVKEKLETDPRYKAVETSAAREEFFKNY----------------------------------- 745

  Fly   804 EKDKGRKDRGRSRSKDKDREHKSSKEKDKDKEEKSKSEKSKKRDTTPEEGEHREESEREERAGSD 868

Zfish   746 ----------------------------------------------------------------- 745

  Fly   869 DSEVARQRENEAEQKQKEREKKLRVEQSIREREKEVQRTLAGHLRDRDKEREHHMREECIGHFTA 933
               |.|..:|.:.:|:||.||:.|||.|:||||:.|||..:...::.|:|||.|.|||.:.||.|
Zfish   746 ---VERLAKNPSAEKEKELEKQARVEASLRERERTVQRFRSEQTKEIDREREQHKREEAVQHFKA 807

  Fly   934 LLTDLVRTPDFTWKEVKRQLRKDHRWELIESLDREDRERKFNEHIDNLMKKKRERFREMLDEIST 998
            ||:|:|::.|..|.:.:|.||||||||....|:||::||.|||||:.|.|||:|:||::||:.::
Zfish   808 LLSDMVKSSDAAWSDTRRSLRKDHRWESSSLLEREEKERLFNEHIEALAKKKKEQFRQLLDDTTS 872

  Fly   999 LQLTSTWKEIKKLIKEDPRYLKYNSD--KGEREFRDYIKDKTMTAKTSLRELLQECKFITHKSSD 1061
            :.||::|||:|||||||||.:|::|.  |.:|||.||||||.:|||...|.||:|.||||:||..
Zfish   873 ITLTTSWKEVKKLIKEDPRCIKFSSSDRKRQREFDDYIKDKYITAKADFRTLLKENKFITYKSRK 937

  Fly  1062 LIKENPNHLKEIQDILKNDKRYLVLDHMEEERNTIVLGFLEELNKRGPPPPPTASESTRRN 1122
            |::|:..||.:|:.||:.||||||||.|.|||:.:::|::|||.:|||||||||.|..||:
Zfish   938 LMQESEQHLSDIEKILQKDKRYLVLDCMTEERHKLLMGYVEELERRGPPPPPTAFEPARRS 998

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42724	NP_001189184.1	WW	112..144	CDD:197736	18/60 (30%)
		Extensin_2	180..243	CDD:252669	21/88 (24%)
		WW	295..322	CDD:278809	8/26 (31%)
		WW	441..468	CDD:278809	21/26 (81%)
		FF	590..634	CDD:280090	36/43 (84%)
		FF	652..701	CDD:280090	21/48 (44%)
		FF	719..768	CDD:280090	21/50 (42%)
		FAT-like_CAS_C	871..>935	CDD:300863	30/63 (48%)
		FF	930..977	CDD:280090	25/46 (54%)
		FF	983..1036	CDD:128718	31/54 (57%)
		FF	1041..1096	CDD:280090	31/54 (57%)
tcerg1a	NP_938171.2	WW	141..166	CDD:278809	13/24 (54%)
		Drf_FH1	194..334	CDD:283903	33/139 (24%)
		Nuc_recep-AF1	217..334	CDD:288658	27/116 (23%)
		WW	351..378	CDD:278809	8/26 (31%)
		WW	450..478	CDD:197736	22/27 (81%)
		FF	562..611	CDD:280090	38/48 (79%)
		FF	631..678	CDD:280090	20/46 (43%)
		FF	696..745	CDD:280090	21/50 (42%)
		FF	800..851	CDD:280090	26/50 (52%)
		FF	857..912	CDD:128718	31/54 (57%)
		FF	917..976	CDD:280090	31/58 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	79	1.000	Domainoid score	I8612
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	485	1.000	Inparanoid score	I1398
OMA	1	1.010	-	-		QHG52888
OrthoDB	1	1.010	-	-		D1388955at2759
OrthoFinder	1	1.000	-	-		FOG0002297
OrthoInspector	1	1.000	-	-		otm25195
orthoMCL	1	0.900	-	-		OOG6_103069
Panther	1	1.100	-	-	O	PTHR15377
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3901
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.980