DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42724 and TCERG1L

DIOPT Version :9

Sequence 1:	NP_001189184.1	Gene:	CG42724 / 40785	FlyBaseID:	FBgn0261641	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	NP_777597.2	Gene:	TCERG1L / 256536	HGNCID:	23533	Length:	586	Species:	Homo sapiens

Alignment Length:	692	Identity:	199/692 - (28%)
Similarity:	311/692 - (44%)	Gaps:	172/692 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 QQQQLQQQQQPQQPQQQAPSGANGVTGPPEIWVETKAEDGRSYYYHAVTRETTWSRPDGPAVKIM 150
            :::||||||..::.....|..|.....||.:|:.
Human    10 RRRQLQQQQPRRRQPLLWPMDAEPPPPPPWVWMV------------------------------- 43

  Fly   151 TQAEVEEMAKRPAQAAKTEAKAGETSVEIPPVSSHLTSQPPPHLMSQPPPNAAAPLLSQPPPNVR 215
                       |..|......||   |.:|||.  |.|.|||          |||||    |.:.
Human    44 -----------PGSAGLLRLSAG---VVVPPVL--LASAPPP----------AAPLL----PGLP 78

  Fly   216 QQPPPMFQPPGMQAPPGFGQPPFCMPPPTYGFP--------GGPAPAGAPWGVGIPPWQQQQHMQ 272
            ..|.|  ..|.:...|....|........:.||        ||.:|:     :|:||
Human    79 GWPAP--SEPVLPLLPLPSAPDSAAAAAAHPFPALHGQWLFGGHSPS-----LGLPP-------- 128

  Fly   273 DKPAKSLIIKPGVIDPAVIAR--AAEWSEHRAPDGRPYYFHAGRGESVW------------EKPQ 323
            ....:.:.:.|.:. |:.:|.  ...|.:.|.|:.:.::.::...:|.|            |||:
Human   129 SSTVELVPVFPHLC-PSALATPIGKSWIDKRIPNCKIFFNNSFALDSTWIHPEESRFFHGHEKPR 192

  Fly   324 ALRDMEA---ARMAAHSGVAPAVATAPSGLPP------HLLPNP-----------MMHMPP---- 364
            .|.:..|   :|.|..|...|.|..||..:|.      .:..:|           |:.:.|
Human   193 LLANQVAVSLSRPAPASRPLPTVVLAPQPIPGGCHNSLKVTSSPAIAIATAAAAAMVSVDPENLR 257

  Fly   365 GSGPPGFDPHAAFAAA--------AAAMKANSENTKAAQAAALEKEAKKAAE-EKRKKEEEQKKA 420
            |..|....|......|        :......:|..:.|:..||...|:|:.: :|..||......
Human   258 GPSPSSVQPRHFLTLAPIKIPLRTSPVSDTRTERGRVARPPALMLRAQKSRDGDKEDKEPPPMLG 322

  Fly   421 AASAKQTDKSRPVTSTPIAGTPWCVVWTGDSRVFFYNPSTRTSVWDRPEDLLNREDVDKAVNERP 485
            .........:|||.|||:.|:|||||||||.||||:||:...|||::|.||.:|.|:::.:.:.|
Human   323 GGEDSTARGNRPVASTPVPGSPWCVVWTGDDRVFFFNPTMHLSVWEKPMDLKDRGDLNRIIEDPP 387

  Fly   486 EQLKTPQEKSAEAEQKSGEEANQEQAKSQVQAQQLDQVQRVDADDDDDDEVIKIRTESESSVEEV 550
            .:.|.....:..::..|.|: |:|                     |.|.:..:.|||...|.:..
Human   388 HKRKLEAPATDNSDGSSSED-NRE---------------------DQDVKTKRNRTEGCGSPKPE 430

  Fly   551 PTKRVRMISKSKRAEDAALEAEQRAAKERALVPLEMRVTQFKEMLREKDVSAFSTWEKELHKIVF 615
            ..||          ||..    .|....:.|:|||.|||.|::||.|:.||||||||||||||||
Human   431 EAKR----------EDKG----TRTPPPQILLPLEERVTHFRDMLLERGVSAFSTWEKELHKIVF 481

  Fly   616 DPRYLLLTSKERKQVFEKYVKDRAEEERKEKRNKMRQKREDFRSLMEEARLHGKSSFSEFSQRNA 680
            |||||||.|:||||:||::||.|.:||.|||::|:...:|:|:.|:||:::..:::|.||:::..
Human   482 DPRYLLLNSEERKQIFEQFVKTRIKEEYKEKKSKLLLAKEEFKKLLEESKVSPRTTFKEFAEKYG 546

  Fly   681 KDERYRAIEKVRERESLFNEYIVEVRRREKEDKLLKKEQIRK 722
            :|:|:|.::|.:::|..||::|:.:::|:||::|    ::||
Human   547 RDQRFRLVQKRKDQEHFFNQFILILKKRDKENRL----RLRK 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42724	NP_001189184.1	WW	112..144	CDD:197736	3/31 (10%)
		Extensin_2	180..243	CDD:252669	19/62 (31%)
		WW	295..322	CDD:278809	6/38 (16%)
		WW	441..468	CDD:278809	18/26 (69%)
		FF	590..634	CDD:280090	34/43 (79%)
		FF	652..701	CDD:280090	15/48 (31%)
		FF	719..768	CDD:280090	2/4 (50%)
		FAT-like_CAS_C	871..>935	CDD:300863
		FF	930..977	CDD:280090
		FF	983..1036	CDD:128718
		FF	1041..1096	CDD:280090
TCERG1L	NP_777597.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30		7/19 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	281..344		16/62 (26%)
		WW	343..370	CDD:278809	18/26 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	378..448		18/105 (17%)
		FF	452..500	CDD:280090	37/47 (79%)
		FF	519..567	CDD:280090	15/47 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	80	1.000	Domainoid score	I8612
eggNOG	1	0.900	-	-		E1_KOG0155
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1388955at2759
OrthoFinder	1	1.000	-	-		FOG0002297
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR15377
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7471
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.950