Protein Alignment CG42724 and TCERG1

DIOPT Version :10

• Sequence 1: NP_001189184.1
• Gene: CG42724 / 40785
• FlyBaseID: FBgn0261641
• Length: 1123
• Species: Drosophila melanogaster
• Sequence 2: NP_001369477.1
• Gene: TCERG1 / 10915
• HGNCID: 15630
• Length: 1115
• Species: Homo sapiens
• Alignment Length: 1279
• Identity: 445/1279 - (34%)
• Similarity: 618/1279 - (48%)
• Gaps: 383/1279 - (29%)

  Fly    27 PPEAGLNGN----------GSGSGSTSQETPNYGVAILKEKPSEAHRSKPFNAFSG--RPIGEHT 79
            ||.|.:.|.          |...|......|.:|      :|.......|.....|  .|:|...
Human    35 PPNAVMRGPPPLMRPPPPFGMMRGPPPPPRPPFG------RPPFDPNMPPMPPPGGIPPPMGPPH 93

  Fly    80 AQQQALQQQQLQQQQQPQQPQQQAPSGANGVTGP--------PEIWVETKAEDGRSYYYHAVTRE 136
            .|:.......:  ...|..|....|.|...||.|        .|||||.|..||:.|||:|.|||
Human    94 LQRPPFMPPPM--SSMPPPPGMMFPPGMPPVTAPGTPALPPTEEIWVENKTPDGKVYYYNARTRE 156

  Fly   137 TTWSRPDGPAVKIM----------TQAEVEEMAKRPAQA-------------------------- 165
            :.|::|||  ||::          .||:|:..|:..|||
Human   157 SAWTKPDG--VKVIQQSELTPMLAAQAQVQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQA 219

  Fly   166 -----------------------------AKTEAKA-----GETSVEIPPVSSHLTSQPP----- 191
                                         |:.:|:|     ..||...|.||:..:|..|
Human   220 QAQAQAQAQAQAQAQAQAQAQAQVQAQVQAQVQAQAVGASTPTTSSPAPAVSTSTSSSTPSSTTS 284

  Fly   192 --------------PHLMSQPPPNA----------------AAPLLSQPPPNVRQQPP--PMFQP 224
                          |....|.|.:|                |.|:.:.|.|:.:..||  |...|
Human   285 TTTTATSVAQTVSTPTTQDQTPSSAVSVATPTVSVSTPAPTATPVQTVPQPHPQTLPPAVPHSVP 349

  Fly   225 PGMQAPPGFGQPPFCMPPPTYGFPGGPAP---------AGAPW---------GV--GI-PPWQQQ 268
            ....|.|.|  ||..:||.....||.|.|         ...|:         ||  |: ||....
Human   350 QPTTAIPAF--PPVMVPPFRVPLPGMPIPLPGVAMMQIVSCPYVKTVATTKTGVLPGMAPPIVPM 412

  Fly   269 QHMQDKPAKSLIIKPGVIDPAVIARA---AEWSEHRAPDGRPYYFHAGRGESVWEKPQALRDMEA 330
            .|.|...|.|         ||.:|.|   :||:|::..||:.||::....||.|||||.|::.|.
Human   413 IHPQVAIAAS---------PATLAGATAVSEWTEYKTADGKTYYYNNRTLESTWEKPQELKEKEK 468

  Fly   331 ARMAAHSGVAPAVATAPSGLPPHLLPNPMMHMPPGSGPPGFDPHAAFAAAAAAMKANSENTKAAQ 395
            ........:     ..||..|   ||                           |:...|:.|
Human   469 LEEKIKEPI-----KEPSEEP---LP---------------------------METEEEDPK--- 495

  Fly   396 AAALEKEAKKAAEEKRKKE-EEQKKAAASAKQTDKSRPVTSTPIAGTPWCVVWTGDSRVFFYNPS 459
                |:..|:..||.:::| .|::|||      .|::||.:.||.|||||||||||.|||||||:
Human   496 ----EEPIKEIKEEPKEEEMTEEEKAA------QKAKPVATAPIPGTPWCVVWTGDERVFFYNPT 550

  Fly   460 TRTSVWDRPEDLLNREDVDKAVNERP-----EQLK-----TPQEKSAEAEQKSGEEANQEQAKSQ 514
            ||.|:||||:||:.|.||||.:.|.|     |:||     ||...|.:..|.|.....:||
Human   551 TRLSMWDRPDDLIGRADVDKIIQEPPHKKGMEELKKLRHPTPTMLSIQKWQFSMSAIKEEQ---- 611

  Fly   515 VQAQQLDQVQRVDADDDDDDEVIKIRTESESSVEEVPTKRVRMISKS----KRA----------- 564
               :.::::        ::||.:|.:            ||.||..||    .||
Human   612 ---ELMEEI--------NEDEPVKAK------------KRKRMSKKSFMWIARASLFRRDDNKDI 653

  Fly   565 ---EDAALEAEQRAAKERALVPLEMRVTQFKEMLREKDVSAFSTWEKELHKIVFDPRYLLLTSKE 626
               ::||:|||.:||:|||:||||.|:.|||:||.|:.|||||||||||||||||||||||..||
Human   654 DSEKEAAMEAEIKAARERAIVPLEARMKQFKDMLLERGVSAFSTWEKELHKIVFDPRYLLLNPKE 718

  Fly   627 RKQVFEKYVKDRAEEERKEKRNKMRQKREDFRSLMEEARLHGKSSFSEFSQRNAKDERYRAIEKV 691
            |||||::|||.||||||:||:||:.|.:|||:.:||||:.:.:::||||:.::|||.|::||||:
Human   719 RKQVFDQYVKTRAEEERREKKNKIMQAKEDFKKMMEEAKFNPRATFSEFAAKHAKDSRFKAIEKM 783

  Fly   692 RERESLFNEYIVEVRRREKEDKLLKKEQIRKDFLDMLRERHDIERHTRWYDIKKKFESDPRYRMV 756
            ::||:||||::...|::||||...:.|:|:.||.::| ..|.::..:||..:|.|.||||||:.|
Human   784 KDREALFNEFVAAARKKEKEDSKTRGEKIKSDFFELL-SNHHLDSQSRWSKVKDKVESDPRYKAV 847

  Fly   757 D-SMYREEYFEDYLHIMKEEKRKEREMREQRERERHRELKSDRKEKDKEKDKGRKDRGRSRSKDK 820
            | |..||:.|:.|:
Human   848 DSSSMREDLFKQYI--------------------------------------------------- 861

  Fly   821 DREHKSSKEKDKDKEEKSKSEKSKKRDTTPEEGEHREESEREERAGSDDSEVARQRENEAEQKQK 885
               .|.:|..|.:||                                                 |
Human   862 ---EKIAKNLDSEKE-------------------------------------------------K 874

  Fly   886 EREKKLRVEQSIREREKEVQRTLAGHLRDRDKEREHHMREECIGHFTALLTDLVRTPDFTWKEVK 950
            |.|::.|:|.|:||||:|||:..:...::.|:|||.|.|||.|.:|.|||:|:||:.|.:|.:.:
Human   875 ELERQARIEASLREREREVQKARSEQTKEIDREREQHKREEAIQNFKALLSDMVRSSDVSWSDTR 939

  Fly   951 RQLRKDHRWELIESLDREDRERKFNEHIDNLMKKKRERFREMLDEISTLQLTSTWKEIKKLIKED 1015
            |.||||||||....|:||::|:.|||||:.|.|||||.||::|||.|.:.|||||||:||:||||
Human   940 RTLRKDHRWESGSLLEREEKEKLFNEHIEALTKKKREHFRQLLDETSAITLTSTWKEVKKIIKED 1004

  Fly  1016 PRYLKYNSD--KGEREFRDYIKDKTMTAKTSLRELLQECKFITHKSSDLIKENPNHLKEIQDILK 1078
            ||.:|::|.  |.:|||.:||:||.:|||...|.||:|.||||::|..||:|:..|||:::.||:
Human  1005 PRCIKFSSSDRKKQREFEEYIRDKYITAKADFRTLLKETKFITYRSKKLIQESDQHLKDVEKILQ 1069

  Fly  1079 NDKRYLVLDHMEEERNTIVLGFLEELNKRGPPPPPTASESTRRN 1122
            |||||||||.:.|||..:::.::::|::|||||||||||.|||:
Human  1070 NDKRYLVLDCVPEERRKLIVAYVDDLDRRGPPPPPTASEPTRRS 1113

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42724	NP_001189184.1	WW	112..144	CDD:197736	18/39 (46%)
		PHA03247	<159..369	CDD:223021	72/330 (22%)
		Extensin_2	180..243	CDD:252669	23/99 (23%)
		WW	295..322	CDD:459800	11/26 (42%)
		PRP40	443..>753	CDD:227435	161/337 (48%)
		COG4913	<865..1105	CDD:443941	118/241 (49%)
		FF	930..977	CDD:426471	24/46 (52%)
		FF	983..1036	CDD:128718	34/54 (63%)
TCERG1	NP_001369477.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..105		14/77 (18%)
		WW	137..162	CDD:459800	14/24 (58%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	259..348		18/88 (20%)
		Herpes_BLLF1	<260..>365	CDD:282904	24/106 (23%)
		PRK13729	<323..>413	CDD:184281	25/91 (27%)
		PRP40	421..1035	CDD:227435	310/801 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	469..526		20/104 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	887..912		11/24 (46%)
		FF	1030..1094	CDD:128718	32/63 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1093..1115		15/21 (71%)