DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42724 and tcerg1l

DIOPT Version :9

Sequence 1:	NP_001189184.1	Gene:	CG42724 / 40785	FlyBaseID:	FBgn0261641	Length:	1123	Species:	Drosophila melanogaster
Sequence 2:	XP_031762230.1	Gene:	tcerg1l / 100127671	XenbaseID:	XB-GENE-982107	Length:	604	Species:	Xenopus tropicalis

Alignment Length:	669	Identity:	190/669 - (28%)
Similarity:	290/669 - (43%)	Gaps:	214/669 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   186 LTSQPPPHLMSQPPPNAAAPLLSQPPPNVRQQPPPMFQPPGMQAPPGFGQPPF---CMP-PPTYG 246
            :.::|||.:...|.......:.:.|||.|...|.|:.|          |.|.:   |.| .|...
Frog    16 VNAEPPPWICVIPDTPGVFRIGAVPPPFVLSHPSPLLQ----------GVPAWQVACDPFLPLMS 70

  Fly   247 FPGGPAPA------------GAP---------------------WGVGIPPWQQQQHMQDKPAKS 278
            .|..|.||            |||                     :..|:||
Frog    71 MPSAPDPAVHQFHLASGQWVGAPSPAFGFSPTSRVELIPLYPHVYASGVPP-------------- 121

  Fly   279 LIIKPGVIDPAVIARAAEWSEHRAPDGRPYYFHAGRGESVW-------------EKP-QALRDME 329
               .||          ..|.|.:.|..:.::.::...||.|             ||| |....|.
Frog   122 ---HPG----------KRWVEKKMPRCKIFFNNSFALESSWMHQPEELIVIQGLEKPNQRASQMT 173

  Fly   330 AA-------------------RMA--AHSGV------------------APAV------------ 343
            .|                   ||:  ..||:                  |||.
Frog   174 MAVSKPSTPSRPLRTVILSPQRMSGLCQSGIIKPISSNQALAIVGTVTAAPAALIGVNSEPTQEL 238

  Fly   344 --ATAP--SGLPPHLLPNPMMHMPPGSGPPGFDPHAA-----------FAAAAAAM--------- 384
              ||.|  ..|.|..:|....|:  ..||.....|.|           .|.|...|
Frog   239 SSATVPPCQMLTPIKMPFIASHL--AGGPSRIAAHVAPLRPSQLARLTTAPALTFMTTRLMDEAP 301

  Fly   385 --KANSENTKAAQAAALEKEAKKAAEEKRKKEEEQKKAAASAKQTD-KSRPVTSTPIAGTPWCVV 446
              |....|:.:..||.:....||....|..:::...|..:..:.|: .::||.|.|:.|:|||||
Frog   302 NDKNKDANSASCSAALILHSEKKNKPSKMDEKDSSIKIPSEEECTNIGNKPVASRPVPGSPWCVV 366

  Fly   447 WTGDSRVFFYNPSTRTSVWDRPEDLLNREDVDKAVNERPEQLKTPQEKSAEAEQKSG---EEANQ 508
            ||||.:|||:||:.:.||||:|.||.||.|:::.:.:.|.:.|.   .::..::|.|   |:.:.
Frog   367 WTGDDKVFFFNPTIQLSVWDKPIDLKNRIDINRIIEDPPHKRKL---DTSTNDKKGGFVPEDVSD 428

  Fly   509 EQAKSQVQAQQLDQVQRVDADDDDDDEVIKIRTESESSVEEVPTKRVRMISKSKRAEDAALEAEQ 573
            :.:         .:.:|...:|      ::|..|.|:..||            |:.:.::||
Frog   429 DHS---------TKTKRNKTED------LRINEEEEADPEE------------KKEKTSSLE--- 463

  Fly   574 RAAKERALVPLEMRVTQFKEMLREKDVSAFSTWEKELHKIVFDPRYLLLTSKERKQVFEKYVKDR 638
                  .|.|||.|:|.|:.||.|:.|||||||||||||||||||||||.|:|||||||::||.|
Frog   464 ------LLPPLEERMTCFRSMLLERGVSAFSTWEKELHKIVFDPRYLLLNSEERKQVFEQFVKTR 522

  Fly   639 AEEERKEKRNKMRQKREDFRSLMEEARLHGKSSFSEFSQRNAKDERYRAIEKVRERESLFNEYIV 703
            .:||.||||:|:...:|:|:.|:||::|..:::|.||::|..:|:|:||::|.:::|..||::|.
Frog   523 IKEEYKEKRSKLMVAKEEFKKLLEESKLTPRTAFKEFAERYGRDQRFRAVQKKKDQEHFFNQFIN 587

  Fly   704 EVRRREKEDKLLKKEQIRK 722
            .:::|:||::|    ::||
Frog   588 VLKKRDKENRL----RLRK 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42724	NP_001189184.1	WW	112..144	CDD:197736
		Extensin_2	180..243	CDD:252669	15/60 (25%)
		WW	295..322	CDD:278809	7/39 (18%)
		WW	441..468	CDD:278809	18/26 (69%)
		FF	590..634	CDD:280090	35/43 (81%)
		FF	652..701	CDD:280090	18/48 (38%)
		FF	719..768	CDD:280090	2/4 (50%)
		FAT-like_CAS_C	871..>935	CDD:300863
		FF	930..977	CDD:280090
		FF	983..1036	CDD:128718
		FF	1041..1096	CDD:280090
tcerg1l	XP_031762230.1	PRP40	362..>602	CDD:227435	113/282 (40%)
		FF	475..518	CDD:396424	35/42 (83%)
		FF	537..585	CDD:396424	18/47 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	79	1.000	Domainoid score	I8562
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1388955at2759
OrthoFinder	1	1.000	-	-		FOG0002297
OrthoInspector	1	1.000	-	-		otm47937
Panther	1	1.100	-	-	O	PTHR15377
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7471
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.140