Protein Alignment Hr83 and NR2F2

DIOPT Version :10

• Sequence 1: NP_649647.1
• Gene: Hr83 / 40783
• FlyBaseID: FBgn0037436
• Length: 278
• Species: Drosophila melanogaster
• Sequence 2: NP_066285.1
• Gene: NR2F2 / 7026
• HGNCID: 7976
• Length: 414
• Species: Homo sapiens
• Alignment Length: 303
• Identity: 97/303 - (32%)
• Similarity: 137/303 - (45%)
• Gaps: 66/303 - (21%)

  Fly     7 CAVCGDQSSGKHYGVSCCDGCSCFFKRSVRRGSSYACIALVGNCVVDKARRNWCPSCRFQRCLAV 71
            |.||||:|||||||...|:||..||||||||..||.|.| ..||.:|:..||.|..||.::||.|
Human    79 CVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRA-NRNCPIDQHHRNQCQYCRLKKCLKV 142

  Fly    72 GMNAAAVQEERGPRNQ----QVAL----------YRTGRRQAPPSQAAPSPTPH--SQALH---- 116
            ||...|||..|.|..|    |.||          |.:|.... ..:|.|.||..  ||.:.
Human   143 GMRREAVQRGRMPPTQPTHGQFALTNGDPLNCHSYLSGYISL-LLRAEPYPTSRFGSQCMQPNNI 206

  Fly   117 ------FQILAQILVTCLRQAKANEQFALLDRCQQDAIFQVVWSEIFVLRASHWS--LDISAMID 173
                  .::.|::|.:.:..|:....|..|....|.|:.::.|||:|||.|:..|  |.::.::.
Human   207 MGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSMPLHVAPLLA 271

  Fly   174 GCG---------------------DEQLKRLICEAHQLRADVLELNFMESLILCRKELAINAEYA 217
            ..|                     .||:::|    ..|..|..|.:.:::::|...:....::.|
Human   272 AAGLHASPMSADRVVAFMDHIRIFQEQVEKL----KALHVDSAEYSCLKAIVLFTSDACGLSDVA 332

  Fly   218 VI--LGSHSKAALISLARYTLQQSNY----LRFGQLLLGLRQL 254
            .:  |...|:.||....|     |.|    .|||:|||.|..|
Human   333 HVESLQEKSQCALEEYVR-----SQYPNQPTRFGKLLLRLPSL 370

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr83	NP_649647.1	NR_DBD_PNR_like_2	7..88	CDD:143515	46/84 (55%)
NR2F2	NP_066285.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..72
		NR_DBD_COUP_TF	79..151	CDD:143516	42/72 (58%)
		Interaction with ZFPM2. /evidence=ECO:0000250	117..414		71/265 (27%)
		NR_LBD_COUP-TF	177..411	CDD:132746	48/204 (24%)
		Important for dimerization	337..414		15/39 (38%)