DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hr83 and NR2F1

DIOPT Version :9

Sequence 1:	NP_649647.1	Gene:	Hr83 / 40783	FlyBaseID:	FBgn0037436	Length:	278	Species:	Drosophila melanogaster
Sequence 2:	NP_005645.1	Gene:	NR2F1 / 7025	HGNCID:	7975	Length:	423	Species:	Homo sapiens

Alignment Length:	301	Identity:	96/301 - (31%)
Similarity:	137/301 - (45%)	Gaps:	62/301 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 CAVCGDQSSGKHYGVSCCDGCSCFFKRSVRRGSSYACIALVGNCVVDKARRNWCPSCRFQRCLAV 71
            |.||||:|||||||...|:||..||||||||..:|.|.| ..||.:|:..||.|..||.::||.|
Human    86 CVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRA-NRNCPIDQHHRNQCQYCRLKKCLKV 149

  Fly    72 GMNAAAVQEERGPRNQ----QVAL----------YRTGRRQAPPSQAAPSPTPH--SQALH---- 116
            ||...|||..|.|..|    |.||          |.:|.... ..:|.|.||..  ||.:.
Human   150 GMRREAVQRGRMPPTQPNPGQYALTNGDPLNGHCYLSGYISL-LLRAEPYPTSRYGSQCMQPNNI 213

  Fly   117 ------FQILAQILVTCLRQAKANEQFALLDRCQQDAIFQVVWSEIFVLRASHWS--LDISAMID 173
                  .::.|::|.:.:..|:....|..|....|.::.::.|||:|||.|:..|  |.::.::.
Human   214 MGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLNAAQCSMPLHVAPLLA 278

  Fly   174 GCG---------------------DEQLKRLICEAHQLRADVLELNFMESLILCRKELA--INAE 215
            ..|                     .||:::|    ..|..|..|.:.:::::|...:..  .:|.
Human   279 AAGLHASPMSADRVVAFMDHIRIFQEQVEKL----KALHVDSAEYSCLKAIVLFTSDACGLSDAA 339

  Fly   216 YAVILGSHSKAALISLAR--YTLQQSNYLRFGQLLLGLRQL 254
            :...|...|:.||....|  |..|.|   |||:|||.|..|
Human   340 HIESLQEKSQCALEEYVRSQYPNQPS---RFGKLLLRLPSL 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hr83	NP_649647.1	NR_DBD_PNR_like_2	7..88	CDD:143515	45/84 (54%)
NR2F1	NP_005645.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..81
		NR_DBD_COUP_TF	86..158	CDD:143516	41/72 (57%)
		NR_LBD_COUP-TF	184..419	CDD:132746	48/202 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144390
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840