DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hr83 and RXRB

DIOPT Version :9

Sequence 1:	NP_649647.1	Gene:	Hr83 / 40783	FlyBaseID:	FBgn0037436	Length:	278	Species:	Drosophila melanogaster
Sequence 2:	NP_001257330.1	Gene:	RXRB / 6257	HGNCID:	10478	Length:	537	Species:	Homo sapiens

Alignment Length:	325	Identity:	95/325 - (29%)
Similarity:	141/325 - (43%)	Gaps:	68/325 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 CAVCGDQSSGKHYGVSCCDGCSCFFKRSVRRGSSYACIALVGNCVVDKARRNWCPSCRFQRCLAV 71
            ||:|||:||||||||..|:||..||||::|:..:|:| ....:|.|||.:||.|..||:|:|||.
Human   205 CAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSC-RDNKDCTVDKRQRNRCQYCRYQKCLAT 268

  Fly    72 GMNAAAVQEER---------------GPRNQ--------QVALYRTGRR--QAPPSQAAPSPTPH 111
            ||...||||||               .|...        ::|:.:...:  :.|........:|:
Human   269 GMKREAVQEERQRGKDKDGDGEGAGGAPEEMPVDRILEAELAVEQKSDQGVEGPGGTGGSGSSPN 333

  Fly   112 SQALHF-QILAQILVTCLRQAKANEQFALLDRCQQDAIFQVVWSEIFVLRASHWSLDI------- 168
            ....:. |...:.|.|.:..||....|:.|....|..:.:..|:|:.:...||.|:|:
Human   334 DPVTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLA 398

  Fly   169 --------SAMIDGCG---DEQLKR----LICEAHQLRADVLELNFMESLILCR---KELAINAE 215
                    ||...|.|   |..|.|    |:.:...:|.|..||..:.::||..   |.|:..:|
Human   399 TGLHVHRNSAHSAGVGAIFDRSLSRVLTELVSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPSE 463

  Fly   216 YAVI-------LGSHSKAALISLARYTLQQSNYLRFGQLLLGLRQLCLRRFDCALSCMFRSVVRD 273
            ..|:       |.::.|      .:|..||.   ||.:|||.|..|......|.....|..::.|
Human   464 VEVLREKVYASLETYCK------QKYPEQQG---RFAKLLLRLPALRSIGLKCLEHLFFFKLIGD 519

Fly 274 273
Human 520 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hr83	NP_649647.1	NR_DBD_PNR_like_2	7..88	CDD:143515	45/103 (44%)
RXRB	NP_001257330.1	Modulating. /evidence=ECO:0000250	1..204
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	36..181
		NR_DBD_RXR	204..279	CDD:143514	42/74 (57%)
		Hinge	271..295		6/23 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	276..299		5/22 (23%)
		NR_LBD_RXR_like	298..515	CDD:132741	49/225 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	313..336		2/22 (9%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144383
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840